Clustering_results_report
2024-02-02
1 Clustring Processed data without auxiliary variables
1.1 Imporved Deep Empedding Clustering on the encoded data 5 clusters
1.1.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=82) | 1 (N=316) | 2 (N=992) | 3 (N=503) | 4 (N=2) | Total (N=1895) | p value | |
|---|---|---|---|---|---|---|---|
| Age | < 0.001 | ||||||
| Â Â Â Mean (SD) | 68.098 (7.987) | 64.848 (10.014) | 43.517 (13.558) | 49.437 (14.835) | 52.000 (14.142) | 49.718 (15.717) | |
| Â Â Â Range | 37.000 - 86.000 | 20.000 - 97.000 | 17.000 - 81.000 | 18.000 - 80.000 | 42.000 - 62.000 | 17.000 - 97.000 | |
| Gender | 0.599 | ||||||
| Â Â Â No | 34 (41.5%) | 115 (36.4%) | 412 (41.5%) | 202 (40.2%) | 1 (50.0%) | 764 (40.3%) | |
| Â Â Â Yes | 48 (58.5%) | 201 (63.6%) | 580 (58.5%) | 301 (59.8%) | 1 (50.0%) | 1131 (59.7%) | |
| BMI | < 0.001 | ||||||
| Â Â Â Mean (SD) | 28.902 (5.581) | 29.217 (5.289) | 26.162 (4.400) | 27.173 (4.877) | 29.676 (8.939) | 27.062 (4.880) | |
| Â Â Â Range | 19.195 - 46.475 | 18.726 - 50.058 | 17.029 - 45.265 | 17.509 - 48.919 | 23.355 - 35.996 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||||
| Â Â Â Mean (SD) | 43.439 (19.457) | 35.823 (18.247) | 15.575 (11.898) | 20.519 (16.469) | 35.500 (14.849) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 70.000 | 1.000 - 72.000 | -1.000 - 62.000 | -1.000 - 70.000 | 25.000 - 46.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||||
| Â Â Â No | 33 (40.2%) | 144 (45.6%) | 745 (75.1%) | 335 (66.6%) | 0 (0.0%) | 1257 (66.3%) | |
| Â Â Â Yes | 49 (59.8%) | 172 (54.4%) | 247 (24.9%) | 168 (33.4%) | 2 (100.0%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | ||||||
| Â Â Â No | 15 (18.3%) | 92 (29.1%) | 373 (37.6%) | 138 (27.4%) | 0 (0.0%) | 618 (32.6%) | |
| Â Â Â Yes | 67 (81.7%) | 224 (70.9%) | 619 (62.4%) | 365 (72.6%) | 2 (100.0%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | ||||||
| Â Â Â No | 37 (45.1%) | 218 (69.0%) | 834 (84.1%) | 393 (78.1%) | 0 (0.0%) | 1482 (78.2%) | |
| Â Â Â Yes | 45 (54.9%) | 98 (31.0%) | 158 (15.9%) | 110 (21.9%) | 2 (100.0%) | 413 (21.8%) | |
| dyspenea | < 0.001 | ||||||
| Â Â Â No | 21 (25.6%) | 194 (61.4%) | 862 (86.9%) | 403 (80.1%) | 2 (100.0%) | 1482 (78.2%) | |
| Â Â Â Yes | 61 (74.4%) | 122 (38.6%) | 130 (13.1%) | 100 (19.9%) | 0 (0.0%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | ||||||
| Â Â Â No | 30 (36.6%) | 199 (63.0%) | 861 (86.8%) | 384 (76.3%) | 0 (0.0%) | 1474 (77.8%) | |
| Â Â Â Yes | 52 (63.4%) | 117 (37.0%) | 131 (13.2%) | 119 (23.7%) | 2 (100.0%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.586 (0.136) | 0.727 (0.096) | 0.796 (0.072) | 0.775 (0.087) | 0.686 (0.200) | 0.770 (0.096) | |
| Â Â Â Range | 0.230 - 0.817 | 0.259 - 0.994 | 0.467 - 1.028 | 0.424 - 1.590 | 0.545 - 0.828 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||||
| Â Â Â Mean (SD) | 16.097 (14.600) | 7.449 (7.370) | 6.335 (6.685) | 7.733 (7.047) | 24.398 (9.209) | 7.333 (7.677) | |
| Â Â Â Range | -12.121 - 77.242 | -20.000 - 55.102 | -26.774 - 56.067 | -4.776 - 46.196 | 17.886 - 30.909 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||||
| Â Â Â Mean (SD) | 2888.147 (1582.379) | 2845.698 (2059.152) | 1663.281 (2620.355) | 1812.059 (1863.564) | 1211.895 (710.804) | 1952.471 (2355.058) | |
| Â Â Â Range | 57.024 - 5539.290 | 33.570 - 12925.000 | -26261.250 - 38775.000 | -3701.250 - 12925.000 | 709.280 - 1714.509 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||||
| Â Â Â Mean (SD) | 70.629 (13.088) | 87.031 (14.673) | 105.369 (14.169) | 102.913 (19.314) | 92.246 (17.845) | 100.142 (18.166) | |
| Â Â Â Range | 44.477 - 98.316 | 44.453 - 136.295 | 65.414 - 230.491 | 48.917 - 389.709 | 79.627 - 104.864 | 44.453 - 389.709 | |
| kco | < 0.001 | ||||||
| Â Â Â Mean (SD) | 74.706 (13.630) | 88.035 (14.700) | 102.780 (12.796) | 102.296 (14.129) | 97.740 (9.520) | 98.972 (15.443) | |
| Â Â Â Range | 40.972 - 113.475 | 43.704 - 139.418 | 69.265 - 144.168 | 60.955 - 149.720 | 91.008 - 104.471 | 40.972 - 149.720 | |
| FeNO | < 0.001 | ||||||
| Â Â Â Mean (SD) | 22.214 (22.533) | 25.041 (20.858) | 23.687 (19.183) | 29.249 (25.852) | 198.000 (7.071) | 25.509 (22.386) | |
| Â Â Â Range | 3.600 - 155.000 | 4.600 - 155.000 | 3.300 - 176.000 | 5.000 - 226.000 | 193.000 - 203.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.237 (0.166) | 0.216 (0.185) | 0.186 (0.130) | 0.284 (0.187) | 0.850 (0.071) | 0.220 (0.165) | |
| Â Â Â Range | 0.010 - 0.800 | 0.000 - 2.300 | 0.000 - 0.900 | 0.040 - 1.200 | 0.800 - 0.900 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||||
| Â Â Â Mean (SD) | 5.402 (1.870) | 4.165 (1.483) | 3.500 (1.140) | 4.111 (1.393) | 4.250 (0.071) | 3.856 (1.383) | |
| Â Â Â Range | 2.200 - 12.500 | 1.300 - 12.300 | 1.100 - 7.900 | 1.000 - 9.710 | 4.200 - 4.300 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | ||||||
| Â Â Â Mean (SD) | 2.551 (1.500) | 1.838 (0.585) | 1.917 (0.559) | 2.112 (0.689) | 1.800 (0.000) | 1.983 (0.683) | |
| Â Â Â Range | 0.900 - 11.200 | 0.300 - 5.000 | 0.600 - 4.800 | 0.700 - 9.400 | 1.800 - 1.800 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.601 (0.278) | 0.449 (0.156) | 0.390 (0.131) | 0.456 (0.139) | 0.500 (0.000) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 2.400 | 0.200 - 1.100 | 0.200 - 1.000 | 0.200 - 1.100 | 0.500 - 0.500 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.075 (0.045) | 0.002 (0.010) | 0.003 (0.009) | 0.099 (0.021) | 0.000 (0.000) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.200 | 0.000 - 0.080 | 0.000 - 0.060 | 0.000 - 0.300 | 0.000 - 0.000 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||||
| Â Â Â No | 42 (51.2%) | 172 (54.4%) | 251 (25.3%) | 181 (36.0%) | 1 (50.0%) | 647 (34.1%) | |
| Â Â Â Yes | 40 (48.8%) | 144 (45.6%) | 741 (74.7%) | 322 (64.0%) | 1 (50.0%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | ||||||
| Â Â Â No | 65 (79.3%) | 216 (68.4%) | 431 (43.4%) | 254 (50.5%) | 0 (0.0%) | 966 (51.0%) | |
| Â Â Â Yes | 17 (20.7%) | 100 (31.6%) | 561 (56.6%) | 249 (49.5%) | 2 (100.0%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.141 | ||||||
| Â Â Â No | 73 (89.0%) | 293 (92.7%) | 942 (95.0%) | 477 (94.8%) | 2 (100.0%) | 1787 (94.3%) | |
| Â Â Â Yes | 9 (11.0%) | 23 (7.3%) | 50 (5.0%) | 26 (5.2%) | 0 (0.0%) | 108 (5.7%) | |
| nasal_plyposis | 0.022 | ||||||
| Â Â Â No | 42 (51.2%) | 168 (53.2%) | 595 (60.0%) | 266 (52.9%) | 2 (100.0%) | 1073 (56.6%) | |
| Â Â Â Yes | 40 (48.8%) | 148 (46.8%) | 397 (40.0%) | 237 (47.1%) | 0 (0.0%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | ||||||
| Â Â Â No | 17 (20.7%) | 85 (26.9%) | 369 (37.2%) | 131 (26.0%) | 0 (0.0%) | 602 (31.8%) | |
| Â Â Â Yes | 65 (79.3%) | 231 (73.1%) | 623 (62.8%) | 372 (74.0%) | 2 (100.0%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | ||||||
| Â Â Â onlys saba or non users | 40 (48.8%) | 188 (59.5%) | 716 (72.2%) | 337 (67.0%) | 2 (100.0%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 11 (13.4%) | 63 (19.9%) | 161 (16.2%) | 102 (20.3%) | 0 (0.0%) | 337 (17.8%) | |
| Â Â Â step3 | 4 (4.9%) | 15 (4.7%) | 60 (6.0%) | 17 (3.4%) | 0 (0.0%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 27 (32.9%) | 50 (15.8%) | 55 (5.5%) | 47 (9.3%) | 0 (0.0%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | ||||||
| Â Â Â No | 58 (70.7%) | 293 (92.7%) | 970 (97.8%) | 481 (95.6%) | 2 (100.0%) | 1804 (95.2%) | |
| Â Â Â Yes | 24 (29.3%) | 23 (7.3%) | 22 (2.2%) | 22 (4.4%) | 0 (0.0%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | ||||||
| Â Â Â No | 46 (56.1%) | 234 (74.1%) | 887 (89.4%) | 420 (83.5%) | 2 (100.0%) | 1589 (83.9%) | |
| Â Â Â Yes | 36 (43.9%) | 82 (25.9%) | 105 (10.6%) | 83 (16.5%) | 0 (0.0%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | ||||||
| Â Â Â No | 45 (54.9%) | 239 (75.6%) | 885 (89.2%) | 417 (82.9%) | 2 (100.0%) | 1588 (83.8%) | |
| Â Â Â Yes | 37 (45.1%) | 77 (24.4%) | 107 (10.8%) | 86 (17.1%) | 0 (0.0%) | 307 (16.2%) | |
| gina_control | < 0.001 | ||||||
| Â Â Â controlled | 10 (12.2%) | 89 (28.2%) | 436 (44.0%) | 182 (36.2%) | 0 (0.0%) | 717 (37.8%) | |
| Â Â Â partially controlled | 43 (52.4%) | 166 (52.5%) | 448 (45.2%) | 234 (46.5%) | 1 (50.0%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 29 (35.4%) | 61 (19.3%) | 108 (10.9%) | 87 (17.3%) | 1 (50.0%) | 286 (15.1%) | |
| education | < 0.001 | ||||||
| Â Â Â primary | 10 (12.2%) | 127 (40.2%) | 535 (53.9%) | 237 (47.1%) | 1 (50.0%) | 910 (48.0%) | |
| Â Â Â secondary | 35 (42.7%) | 107 (33.9%) | 398 (40.1%) | 209 (41.6%) | 0 (0.0%) | 749 (39.5%) | |
| Â Â Â tertiary | 37 (45.1%) | 82 (25.9%) | 59 (5.9%) | 57 (11.3%) | 1 (50.0%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | ||||||
| Â Â Â No | 44 (53.7%) | 163 (51.6%) | 473 (47.7%) | 305 (60.6%) | 1 (50.0%) | 986 (52.0%) | |
| Â Â Â Yes | 38 (46.3%) | 153 (48.4%) | 519 (52.3%) | 198 (39.4%) | 1 (50.0%) | 909 (48.0%) | |
| smoking_status | < 0.001 | ||||||
| Â Â Â never smoker | 15 (18.3%) | 147 (46.5%) | 607 (61.2%) | 259 (51.5%) | 1 (50.0%) | 1029 (54.3%) | |
| Â Â Â former smokers | 43 (52.4%) | 148 (46.8%) | 315 (31.8%) | 192 (38.2%) | 1 (50.0%) | 699 (36.9%) | |
| Â Â Â current smoker | 24 (29.3%) | 21 (6.6%) | 70 (7.1%) | 52 (10.3%) | 0 (0.0%) | 167 (8.8%) | |
| pack_years | < 0.001 | ||||||
| Â Â Â Mean (SD) | 39.904 (24.405) | 21.284 (16.953) | 7.390 (8.569) | 10.505 (10.296) | 10.725 (7.743) | 11.945 (14.129) | |
| Â Â Â Range | 0.200 - 112.500 | 0.000 - 90.000 | 0.000 - 69.000 | 0.000 - 60.000 | 5.250 - 16.200 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||||
| Â Â Â No | 25 (30.5%) | 85 (26.9%) | 426 (42.9%) | 181 (36.0%) | 2 (100.0%) | 719 (37.9%) | |
| Â Â Â Yes | 57 (69.5%) | 231 (73.1%) | 566 (57.1%) | 322 (64.0%) | 0 (0.0%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | ||||||
| Â Â Â No | 36 (43.9%) | 153 (48.4%) | 661 (66.6%) | 298 (59.2%) | 1 (50.0%) | 1149 (60.6%) | |
| Â Â Â Yes | 46 (56.1%) | 163 (51.6%) | 331 (33.4%) | 205 (40.8%) | 1 (50.0%) | 746 (39.4%) | |
| household_damage | 0.007 | ||||||
| Â Â Â No | 77 (93.9%) | 291 (92.1%) | 853 (86.0%) | 435 (86.5%) | 1 (50.0%) | 1657 (87.4%) | |
| Â Â Â Yes | 5 (6.1%) | 25 (7.9%) | 139 (14.0%) | 68 (13.5%) | 1 (50.0%) | 238 (12.6%) | |
| exertion_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 31 (37.8%) | 77 (24.4%) | 431 (43.4%) | 169 (33.6%) | 0 (0.0%) | 708 (37.4%) | |
| Â Â Â Yes | 51 (62.2%) | 239 (75.6%) | 561 (56.6%) | 334 (66.4%) | 2 (100.0%) | 1187 (62.6%) | |
| infection_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 35 (42.7%) | 69 (21.8%) | 460 (46.4%) | 176 (35.0%) | 0 (0.0%) | 740 (39.1%) | |
| Â Â Â Yes | 47 (57.3%) | 247 (78.2%) | 532 (53.6%) | 327 (65.0%) | 2 (100.0%) | 1155 (60.9%) | |
| allergen_triggered_asthma | 0.003 | ||||||
| Â Â Â No | 65 (79.3%) | 202 (63.9%) | 730 (73.6%) | 343 (68.2%) | 1 (50.0%) | 1341 (70.8%) | |
| Â Â Â Yes | 17 (20.7%) | 114 (36.1%) | 262 (26.4%) | 160 (31.8%) | 1 (50.0%) | 554 (29.2%) | |
| irritant_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 68 (82.9%) | 242 (76.6%) | 879 (88.6%) | 422 (83.9%) | 1 (50.0%) | 1612 (85.1%) | |
| Â Â Â Yes | 14 (17.1%) | 74 (23.4%) | 113 (11.4%) | 81 (16.1%) | 1 (50.0%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 50 (61.0%) | 175 (55.4%) | 743 (74.9%) | 321 (63.8%) | 1 (50.0%) | 1290 (68.1%) | |
| Â Â Â Yes | 32 (39.0%) | 141 (44.6%) | 249 (25.1%) | 182 (36.2%) | 1 (50.0%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 73 (89.0%) | 275 (87.0%) | 939 (94.7%) | 443 (88.1%) | 2 (100.0%) | 1732 (91.4%) | |
| Â Â Â Yes | 9 (11.0%) | 41 (13.0%) | 53 (5.3%) | 60 (11.9%) | 0 (0.0%) | 163 (8.6%) | |
| XCOPD | < 0.001 | ||||||
| Â Â Â No | 25 (30.5%) | 233 (73.7%) | 940 (94.8%) | 455 (90.5%) | 2 (100.0%) | 1655 (87.3%) | |
| Â Â Â Yes | 57 (69.5%) | 83 (26.3%) | 52 (5.2%) | 48 (9.5%) | 0 (0.0%) | 240 (12.7%) |
1.1.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## XCOPD 9.679075e-74 4
## dyspenea 7.722436e-49 4
## education 6.703361e-37 8
## Chronic_productive_cough 9.472423e-37 4
## Hosptalization_last_year 2.285026e-26 4
## Cough 7.115386e-26 4
## spt_any 1.426106e-21 4
## Recurrent_wheeze 8.394793e-20 4
## Emergency_last_year 4.539447e-19 4
## familial_allergy 2.067649e-18 4
## severe_asthma 3.253187e-18 4
## smoking_status 5.756605e-18 8
## gina_steps 1.115466e-15 12
## infection_triggered_asthma 1.022156e-13 4
## gina_control 1.789332e-13 8
## weather_triggered_asthma 2.139274e-10 4
## smoking_exposure_at_work 4.307497e-09 4
## exertion_triggered_asthma 1.169273e-08 4
## smoking_exposure_at_home 1.233920e-06 4
## irritant_triggered_asthma 3.913141e-06 4
## Ever_rhinitis 4.690233e-06 4
## emotion_triggered_asthma 8.021889e-06 4
## Breathlessness 1.404463e-05 4
## urbanization_level 1.551185e-04 4
## allergen_triggered_asthma 3.205271e-03 4
## household_damage 6.639531e-03 4
## nasal_plyposis 2.183506e-02 4
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=Yes 23.750000 69.51220 12.664908 7.012564e-35
## dyspenea=Yes 14.769976 74.39024 21.794195 2.600898e-25
## Chronic_productive_cough=Yes 12.351544 63.41463 22.216359 2.763987e-16
## Hosptalization_last_year=Yes 26.373626 29.26829 4.802111 4.235715e-14
## education=tertiary 15.677966 45.12195 12.453826 5.375905e-14
## Recurrent_wheeze=Yes 10.895884 54.87805 21.794195 2.561826e-11
## severe_asthma=Yes 12.052117 45.12195 16.200528 2.858064e-10
## Emergency_last_year=Yes 11.764706 43.90244 16.147757 1.215057e-09
## gina_steps=step4 or 5 15.083799 32.92683 9.445910 1.409243e-09
## smoking_status=current smoker 14.371257 29.26829 8.812665 4.387193e-08
## familial_allergy=No 6.728778 79.26829 50.976253 7.892647e-08
## Cough=Yes 7.680251 59.75610 33.667546 8.910290e-07
## gina_control=uncontrolled 10.139860 35.36585 15.092348 3.395584e-06
## spt_any=No 6.491499 51.21951 34.142480 1.221163e-03
## smoking_exposure_at_work=Yes 6.166220 56.09756 39.366755 1.864410e-03
## Breathlessness=Yes 5.246672 81.70732 67.387863 3.417913e-03
## smoking_status=former smokers 6.151645 52.43902 36.886544 3.544892e-03
## Ever_rhinitis=Yes 5.027069 79.26829 68.232190 2.494794e-02
## Ever_rhinitis=No 2.823920 20.73171 31.767810 2.494794e-02
## Breathlessness=No 2.427184 18.29268 32.612137 3.417913e-03
## smoking_exposure_at_work=No 3.133159 43.90244 60.633245 1.864410e-03
## spt_any=Yes 3.205128 48.78049 65.857520 1.221163e-03
## gina_steps=onlys saba or non users 3.117693 48.78049 67.704485 3.072829e-04
## Cough=No 2.625298 40.24390 66.332454 8.910290e-07
## gina_control=controlled 1.394700 12.19512 37.836412 1.622000e-07
## familial_allergy=Yes 1.829925 20.73171 49.023747 7.892647e-08
## Emergency_last_year=No 2.894902 56.09756 83.852243 1.215057e-09
## severe_asthma=No 2.833753 54.87805 83.799472 2.858064e-10
## Recurrent_wheeze=No 2.496626 45.12195 78.205805 2.561826e-11
## smoking_status=never smoker 1.457726 18.29268 54.300792 9.413612e-12
## education=primary 1.098901 12.19512 48.021108 2.504760e-12
## Hosptalization_last_year=No 3.215078 70.73171 95.197889 4.235715e-14
## Chronic_productive_cough=No 2.035278 36.58537 77.783641 2.763987e-16
## dyspenea=No 1.417004 25.60976 78.205805 2.600898e-25
## XCOPD=No 1.510574 30.48780 87.335092 7.012564e-35
## v.test
## XCOPD=Yes 12.320651
## dyspenea=Yes 10.395438
## Chronic_productive_cough=Yes 8.183202
## Hosptalization_last_year=Yes 7.553544
## education=tertiary 7.522450
## Recurrent_wheeze=Yes 6.669783
## severe_asthma=Yes 6.306288
## Emergency_last_year=Yes 6.078244
## gina_steps=step4 or 5 6.054420
## smoking_status=current smoker 5.474512
## familial_allergy=No 5.369566
## Cough=Yes 4.914294
## gina_control=uncontrolled 4.645315
## spt_any=No 3.233890
## smoking_exposure_at_work=Yes 3.111022
## Breathlessness=Yes 2.927416
## smoking_status=former smokers 2.916054
## Ever_rhinitis=Yes 2.242208
## Ever_rhinitis=No -2.242208
## Breathlessness=No -2.927416
## smoking_exposure_at_work=No -3.111022
## spt_any=Yes -3.233890
## gina_steps=onlys saba or non users -3.609082
## Cough=No -4.914294
## gina_control=controlled -5.238143
## familial_allergy=Yes -5.369566
## Emergency_last_year=No -6.078244
## severe_asthma=No -6.306288
## Recurrent_wheeze=No -6.669783
## smoking_status=never smoker -6.815195
## education=primary -7.003035
## Hosptalization_last_year=No -7.553544
## Chronic_productive_cough=No -8.183202
## dyspenea=No -10.395438
## XCOPD=No -12.320651
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## Cough=Yes 26.959248 54.430380 33.667546 8.060101e-17
## spt_any=No 26.584235 54.430380 34.142480 4.520947e-16
## dyspenea=Yes 29.539952 38.607595 21.794195 5.995876e-14
## XCOPD=Yes 34.583333 26.265823 12.664908 2.791108e-13
## education=tertiary 34.745763 25.949367 12.453826 3.025872e-13
## infection_triggered_asthma=Yes 21.385281 78.164557 60.949868 1.406994e-12
## familial_allergy=No 22.360248 68.354430 50.976253 8.611418e-12
## Chronic_productive_cough=Yes 27.790974 37.025316 22.216359 3.900668e-11
## exertion_triggered_asthma=Yes 20.134794 75.632911 62.638522 8.757269e-08
## weather_triggered_asthma=Yes 23.305785 44.620253 31.926121 2.181433e-07
## Emergency_last_year=Yes 26.797386 25.949367 16.147757 8.551826e-07
## smoking_exposure_at_work=Yes 21.849866 51.582278 39.366755 1.478165e-06
## smoking_exposure_at_home=Yes 19.642857 73.101266 62.058047 6.578895e-06
## irritant_triggered_asthma=Yes 26.148410 23.417722 14.934037 1.053549e-05
## Recurrent_wheeze=Yes 23.728814 31.012658 21.794195 2.644423e-05
## severe_asthma=Yes 25.081433 24.367089 16.200528 3.671292e-05
## gina_steps=step4 or 5 27.932961 15.822785 9.445910 6.801182e-05
## smoking_status=former smokers 21.173104 46.835443 36.886544 7.357111e-05
## emotion_triggered_asthma=Yes 25.153374 12.974684 8.601583 3.860746e-03
## allergen_triggered_asthma=Yes 20.577617 36.075949 29.234828 3.952144e-03
## household_damage=No 17.561859 92.088608 87.440633 4.507332e-03
## gina_control=uncontrolled 21.328671 19.303797 15.092348 2.547513e-02
## Hosptalization_last_year=Yes 25.274725 7.278481 4.802111 3.209178e-02
## gina_control=partially controlled 18.609865 52.531646 47.071240 3.359436e-02
## Ever_rhinitis=Yes 17.865429 73.101266 68.232190 4.027689e-02
## Ever_rhinitis=No 14.119601 26.898734 31.767810 4.027689e-02
## Hosptalization_last_year=No 16.241685 92.721519 95.197889 3.209178e-02
## education=secondary 14.285714 33.860759 39.525066 2.346923e-02
## household_damage=Yes 10.504202 7.911392 12.559367 4.507332e-03
## allergen_triggered_asthma=No 15.063386 63.924051 70.765172 3.952144e-03
## emotion_triggered_asthma=No 15.877598 87.025316 91.398417 3.860746e-03
## smoking_status=never smoker 14.285714 46.518987 54.300792 2.434957e-03
## education=primary 13.956044 40.189873 48.021108 2.243327e-03
## gina_steps=onlys saba or non users 14.653157 59.493671 67.704485 7.615232e-04
## gina_control=controlled 12.412831 28.164557 37.836412 8.233963e-05
## severe_asthma=No 15.050378 75.632911 83.799472 3.671292e-05
## Recurrent_wheeze=No 14.709852 68.987342 78.205805 2.644423e-05
## irritant_triggered_asthma=No 15.012407 76.582278 85.065963 1.053549e-05
## smoking_exposure_at_home=No 11.821975 26.898734 37.941953 6.578895e-06
## smoking_exposure_at_work=No 13.315927 48.417722 60.633245 1.478165e-06
## Emergency_last_year=No 14.726243 74.050633 83.852243 8.551826e-07
## weather_triggered_asthma=No 13.565891 55.379747 68.073879 2.181433e-07
## exertion_triggered_asthma=No 10.875706 24.367089 37.361478 8.757269e-08
## Chronic_productive_cough=No 13.500678 62.974684 77.783641 3.900668e-11
## familial_allergy=Yes 10.764263 31.645570 49.023747 8.611418e-12
## infection_triggered_asthma=No 9.324324 21.835443 39.050132 1.406994e-12
## XCOPD=No 14.078550 73.734177 87.335092 2.791108e-13
## dyspenea=No 13.090418 61.392405 78.205805 5.995876e-14
## spt_any=Yes 11.538462 45.569620 65.857520 4.520947e-16
## Cough=No 11.455847 45.569620 66.332454 8.060101e-17
## v.test
## Cough=Yes 8.330354
## spt_any=No 8.123724
## dyspenea=Yes 7.508172
## XCOPD=Yes 7.304109
## education=tertiary 7.293240
## infection_triggered_asthma=Yes 7.083361
## familial_allergy=No 6.827987
## Chronic_productive_cough=Yes 6.607802
## exertion_triggered_asthma=Yes 5.350787
## weather_triggered_asthma=Yes 5.183172
## Emergency_last_year=Yes 4.922334
## smoking_exposure_at_work=Yes 4.814165
## smoking_exposure_at_home=Yes 4.506876
## irritant_triggered_asthma=Yes 4.405881
## Recurrent_wheeze=Yes 4.202107
## severe_asthma=Yes 4.127249
## gina_steps=step4 or 5 3.983136
## smoking_status=former smokers 3.964431
## emotion_triggered_asthma=Yes 2.889321
## allergen_triggered_asthma=Yes 2.881956
## household_damage=No 2.840284
## gina_control=uncontrolled 2.234121
## Hosptalization_last_year=Yes 2.143266
## gina_control=partially controlled 2.124907
## Ever_rhinitis=Yes 2.050898
## Ever_rhinitis=No -2.050898
## Hosptalization_last_year=No -2.143266
## education=secondary -2.265709
## household_damage=Yes -2.840284
## allergen_triggered_asthma=No -2.881956
## emotion_triggered_asthma=No -2.889321
## smoking_status=never smoker -3.031309
## education=primary -3.055971
## gina_steps=onlys saba or non users -3.366414
## gina_control=controlled -3.937486
## severe_asthma=No -4.127249
## Recurrent_wheeze=No -4.202107
## irritant_triggered_asthma=No -4.405881
## smoking_exposure_at_home=No -4.506876
## smoking_exposure_at_work=No -4.814165
## Emergency_last_year=No -4.922334
## weather_triggered_asthma=No -5.183172
## exertion_triggered_asthma=No -5.350787
## Chronic_productive_cough=No -6.607802
## familial_allergy=Yes -6.827987
## infection_triggered_asthma=No -7.083361
## XCOPD=No -7.304109
## dyspenea=No -7.508172
## spt_any=Yes -8.123724
## Cough=No -8.330354
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=No 56.79758 94.758065 87.335092 3.060810e-25
## Chronic_productive_cough=No 58.41248 86.794355 77.783641 2.539162e-23
## dyspenea=No 58.16464 86.895161 78.205805 4.583995e-22
## spt_any=Yes 59.37500 74.697581 65.857520 1.625677e-17
## Cough=No 59.26810 75.100806 66.332454 2.301099e-17
## Emergency_last_year=No 55.82127 89.415323 83.852243 4.623685e-12
## familial_allergy=Yes 60.38751 56.552419 49.023747 6.023414e-12
## infection_triggered_asthma=No 62.16216 46.370968 39.050132 6.713307e-12
## severe_asthma=No 55.73048 89.213710 83.799472 1.817961e-11
## weather_triggered_asthma=No 57.59690 74.899194 68.073879 2.383454e-11
## Recurrent_wheeze=No 56.27530 84.072581 78.205805 8.735221e-11
## smoking_status=never smoker 58.98931 61.189516 54.300792 2.760663e-10
## gina_control=controlled 60.80893 43.951613 37.836412 8.267649e-09
## exertion_triggered_asthma=No 60.87571 43.447581 37.361478 8.912216e-09
## smoking_exposure_at_work=No 57.52829 66.633065 60.633245 2.128699e-08
## Hosptalization_last_year=No 53.76940 97.782258 95.197889 2.394626e-08
## education=primary 58.79121 53.931452 48.021108 6.682292e-08
## Ever_rhinitis=No 61.29568 37.197581 31.767810 9.658174e-08
## emotion_triggered_asthma=No 54.21478 94.657258 91.398417 1.043022e-07
## Breathlessness=No 60.35599 37.600806 32.612137 1.154983e-06
## smoking_exposure_at_home=No 59.24896 42.943548 37.941953 2.514286e-06
## irritant_triggered_asthma=No 54.52854 88.608871 85.065963 5.865864e-06
## gina_steps=onlys saba or non users 55.80670 72.177419 67.704485 1.302170e-05
## urbanization_level=Yes 57.09571 52.318548 47.968338 7.132078e-05
## nasal_plyposis=No 55.45200 59.979839 56.622691 2.016188e-03
## allergen_triggered_asthma=No 54.43699 73.588710 70.765172 4.683018e-03
## gina_steps=step3 62.50000 6.048387 5.065963 4.110178e-02
## household_damage=Yes 58.40336 14.012097 12.559367 4.556700e-02
## household_damage=No 51.47858 85.987903 87.440633 4.556700e-02
## smoking_status=current smoker 41.91617 7.056452 8.812665 4.827822e-03
## allergen_triggered_asthma=Yes 47.29242 26.411290 29.234828 4.683018e-03
## nasal_plyposis=Yes 48.29684 40.020161 43.377309 2.016188e-03
## urbanization_level=No 47.97160 47.681452 52.031662 7.132078e-05
## irritant_triggered_asthma=Yes 39.92933 11.391129 14.934037 5.865864e-06
## smoking_exposure_at_home=Yes 48.12925 57.056452 62.058047 2.514286e-06
## smoking_status=former smokers 45.06438 31.754032 36.886544 1.235709e-06
## Breathlessness=Yes 48.47298 62.399194 67.387863 1.154983e-06
## emotion_triggered_asthma=Yes 32.51534 5.342742 8.601583 1.043022e-07
## Ever_rhinitis=Yes 48.18252 62.802419 68.232190 9.658174e-08
## gina_control=uncontrolled 37.76224 10.887097 15.092348 8.273967e-08
## Hosptalization_last_year=Yes 24.17582 2.217742 4.802111 2.394626e-08
## smoking_exposure_at_work=Yes 44.36997 33.366935 39.366755 2.128699e-08
## exertion_triggered_asthma=Yes 47.26201 56.552419 62.638522 8.912216e-09
## gina_steps=step4 or 5 30.72626 5.544355 9.445910 9.470185e-10
## Recurrent_wheeze=Yes 38.25666 15.927419 21.794195 8.735221e-11
## weather_triggered_asthma=Yes 41.15702 25.100806 31.926121 2.383454e-11
## severe_asthma=Yes 34.85342 10.786290 16.200528 1.817961e-11
## infection_triggered_asthma=Yes 46.06061 53.629032 60.949868 6.713307e-12
## familial_allergy=No 44.61698 43.447581 50.976253 6.023414e-12
## Emergency_last_year=Yes 34.31373 10.584677 16.147757 4.623685e-12
## Cough=Yes 38.71473 24.899194 33.667546 2.301099e-17
## spt_any=No 38.79444 25.302419 34.142480 1.625677e-17
## education=tertiary 25.00000 5.947581 12.453826 8.193551e-20
## dyspenea=Yes 31.47700 13.104839 21.794195 4.583995e-22
## Chronic_productive_cough=Yes 31.11639 13.205645 22.216359 2.539162e-23
## XCOPD=Yes 21.66667 5.241935 12.664908 3.060810e-25
## v.test
## XCOPD=No 10.379905
## Chronic_productive_cough=No 9.949318
## dyspenea=No 9.657159
## spt_any=Yes 8.517832
## Cough=No 8.477487
## Emergency_last_year=No 6.916675
## familial_allergy=Yes 6.879095
## infection_triggered_asthma=No 6.863629
## severe_asthma=No 6.719943
## weather_triggered_asthma=No 6.680366
## Recurrent_wheeze=No 6.487362
## smoking_status=never smoker 6.311655
## gina_control=controlled 5.762909
## exertion_triggered_asthma=No 5.750230
## smoking_exposure_at_work=No 5.601202
## Hosptalization_last_year=No 5.580765
## education=primary 5.399511
## Ever_rhinitis=No 5.333041
## emotion_triggered_asthma=No 5.319065
## Breathlessness=No 4.863208
## smoking_exposure_at_home=No 4.706968
## irritant_triggered_asthma=No 4.531167
## gina_steps=onlys saba or non users 4.359740
## urbanization_level=Yes 3.971836
## nasal_plyposis=No 3.087837
## allergen_triggered_asthma=No 2.828066
## gina_steps=step3 2.042502
## household_damage=Yes 1.999382
## household_damage=No -1.999382
## smoking_status=current smoker -2.818303
## allergen_triggered_asthma=Yes -2.828066
## nasal_plyposis=Yes -3.087837
## urbanization_level=No -3.971836
## irritant_triggered_asthma=Yes -4.531167
## smoking_exposure_at_home=Yes -4.706968
## smoking_status=former smokers -4.849824
## Breathlessness=Yes -4.863208
## emotion_triggered_asthma=Yes -5.319065
## Ever_rhinitis=Yes -5.333041
## gina_control=uncontrolled -5.361050
## Hosptalization_last_year=Yes -5.580765
## smoking_exposure_at_work=Yes -5.601202
## exertion_triggered_asthma=Yes -5.750230
## gina_steps=step4 or 5 -6.118093
## Recurrent_wheeze=Yes -6.487362
## weather_triggered_asthma=Yes -6.680366
## severe_asthma=Yes -6.719943
## infection_triggered_asthma=Yes -6.863629
## familial_allergy=No -6.879095
## Emergency_last_year=Yes -6.916675
## Cough=Yes -8.477487
## spt_any=No -8.517832
## education=tertiary -9.110590
## dyspenea=Yes -9.657159
## Chronic_productive_cough=Yes -9.949318
## XCOPD=Yes -10.379905
##
## $`3`
## Cla/Mod Mod/Cla Global p.value
## urbanization_level=No 30.93306 60.636183 52.031662 6.314004e-06
## Ever_rhinitis=Yes 28.77030 73.956262 68.232190 1.167860e-03
## emotion_triggered_asthma=Yes 36.80982 11.928429 8.601583 2.621155e-03
## Breathlessness=Yes 28.58262 72.564612 67.387863 3.609026e-03
## XCOPD=No 27.49245 90.457256 87.335092 1.235015e-02
## weather_triggered_asthma=Yes 30.08264 36.182903 31.926121 1.766755e-02
## infection_triggered_asthma=Yes 28.31169 65.009940 60.949868 2.908232e-02
## exertion_triggered_asthma=Yes 28.13816 66.401590 62.638522 4.134934e-02
## nasal_plyposis=Yes 28.83212 47.117296 43.377309 4.889917e-02
## nasal_plyposis=No 24.79031 52.882704 56.622691 4.889917e-02
## exertion_triggered_asthma=No 23.87006 33.598410 37.361478 4.134934e-02
## gina_steps=step3 17.70833 3.379722 5.065963 3.952442e-02
## infection_triggered_asthma=No 23.78378 34.990060 39.050132 2.908232e-02
## weather_triggered_asthma=No 24.88372 63.817097 68.073879 1.766755e-02
## XCOPD=Yes 20.00000 9.542744 12.664908 1.235015e-02
## Breathlessness=No 22.33010 27.435388 32.612137 3.609026e-03
## emotion_triggered_asthma=No 25.57737 88.071571 91.398417 2.621155e-03
## Ever_rhinitis=No 21.76080 26.043738 31.767810 1.167860e-03
## urbanization_level=Yes 21.78218 39.363817 47.968338 6.314004e-06
## v.test
## urbanization_level=No 4.515592
## Ever_rhinitis=Yes 3.246616
## emotion_triggered_asthma=Yes 3.008993
## Breathlessness=Yes 2.910455
## XCOPD=No 2.501978
## weather_triggered_asthma=Yes 2.372513
## infection_triggered_asthma=Yes 2.182369
## exertion_triggered_asthma=Yes 2.040010
## nasal_plyposis=Yes 1.969470
## nasal_plyposis=No -1.969470
## exertion_triggered_asthma=No -2.040010
## gina_steps=step3 -2.058685
## infection_triggered_asthma=No -2.182369
## weather_triggered_asthma=No -2.372513
## XCOPD=Yes -2.501978
## Breathlessness=No -2.910455
## emotion_triggered_asthma=No -3.008993
## Ever_rhinitis=No -3.246616
## urbanization_level=Yes -4.515592
##
## $`4`
## Cla/Mod Mod/Cla Global p.value v.test
## Recurrent_wheeze=Yes 0.4842615 100 21.79420 0.04740870 1.982631
## Chronic_productive_cough=Yes 0.4750594 100 22.21636 0.04926542 1.966287
## Chronic_productive_cough=No 0.0000000 0 77.78364 0.04926542 -1.966287
## Recurrent_wheeze=No 0.0000000 0 78.20580 0.04740870 -1.982631
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Basophiles 0.87724725 0.000000e+00
## pack_years 0.29961792 1.973022e-144
## Age 0.29546907 5.164855e-142
## onset_age_asthma 0.25352283 2.409227e-118
## tlco 0.25090485 6.519551e-117
## kco 0.23471763 3.626168e-108
## FEV1_FVC_ratio_post 0.23342401 1.779168e-107
## Neutrophiles 0.10623052 8.205433e-45
## Monocytes 0.09900329 1.545715e-41
## Eosinophiles 0.07854852 2.008489e-32
## FeNO 0.07458317 1.104150e-30
## Reversibility 0.07125204 3.148620e-29
## BMI 0.05694133 4.763656e-23
## Lymphocytes 0.05202605 5.929249e-21
## pd20 0.03978109 8.441107e-16
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## pack_years 18.320112 3.990427e+01 1.194451e+01 2.425544e+01
## onset_age_asthma 11.900346 4.343902e+01 2.149024e+01 1.933788e+01
## Age 10.826409 6.809756e+01 4.971821e+01 7.938191e+00
## Reversibility 10.568378 1.609689e+01 7.333086e+00 1.451043e+01
## Monocytes 10.504310 6.014634e-01 4.264011e-01 2.759114e-01
## Neutrophiles 10.351033 5.402439e+00 3.856132e+00 1.858335e+00
## Basophiles 8.756496 7.512195e-02 3.133509e-02 4.423452e-02
## Lymphocytes 7.702284 2.551220e+00 1.982802e+00 1.491295e+00
## pd20 3.678210 2.888147e+03 1.952471e+03 1.572701e+03
## BMI 3.491093 2.890206e+01 2.706171e+01 5.546664e+00
## kco -14.547282 7.470600e+01 9.897243e+01 1.354651e+01
## tlco -15.040322 7.062885e+01 1.001420e+02 1.300787e+01
## FEV1_FVC_ratio_post -17.684422 5.863569e-01 7.699727e-01 1.355041e-01
## Overall sd p.value
## pack_years 1.412548e+01 5.719529e-75
## onset_age_asthma 1.707061e+01 1.178569e-32
## Age 1.571245e+01 2.580785e-27
## Reversibility 7.675073e+00 4.176576e-26
## Monocytes 1.542493e-01 8.252400e-26
## Neutrophiles 1.382643e+00 4.139943e-25
## Basophiles 4.628193e-02 2.014141e-18
## Lymphocytes 6.830395e-01 1.336554e-14
## pd20 2.354436e+03 2.348762e-04
## BMI 4.879071e+00 4.810493e-04
## kco 1.543910e+01 6.077039e-48
## tlco 1.816168e+01 3.996004e-51
## FEV1_FVC_ratio_post 9.609862e-02 5.528507e-70
##
## $`1`
## v.test Mean in category Overall mean sd in category
## Age 18.747119 6.484810e+01 4.971821e+01 9.997897e+00
## onset_age_asthma 16.346204 3.582278e+01 2.149024e+01 1.821775e+01
## pack_years 12.873062 2.128442e+01 1.194451e+01 1.692665e+01
## BMI 8.599084 2.921670e+01 2.706171e+01 5.280621e+00
## pd20 7.386136 2.845698e+03 1.952471e+03 2.055891e+03
## Neutrophiles 4.344259 4.164652e+00 3.856132e+00 1.480569e+00
## Monocytes 2.794863 4.485443e-01 4.264011e-01 1.557153e-01
## Lymphocytes -4.129878 1.837911e+00 1.982802e+00 5.836421e-01
## FEV1_FVC_ratio_post -8.802098 7.265256e-01 7.699727e-01 9.631022e-02
## Basophiles -12.236260 2.246835e-03 3.133509e-02 9.564033e-03
## kco -13.791676 8.803547e+01 9.897243e+01 1.467684e+01
## tlco -14.054512 8.703117e+01 1.001420e+02 1.465006e+01
## Overall sd p.value
## Age 1.571245e+01 2.043652e-78
## onset_age_asthma 1.707061e+01 4.629344e-60
## pack_years 1.412548e+01 6.382067e-38
## BMI 4.879071e+00 8.035506e-18
## pd20 2.354436e+03 1.511571e-13
## Neutrophiles 1.382643e+00 1.397467e-05
## Monocytes 1.542493e-01 5.192170e-03
## Lymphocytes 6.830395e-01 3.629564e-05
## FEV1_FVC_ratio_post 9.609862e-02 1.342814e-18
## Basophiles 4.628193e-02 1.989922e-34
## kco 1.543910e+01 2.860349e-43
## tlco 1.816168e+01 7.227871e-45
##
## $`2`
## v.test Mean in category Overall mean sd in category
## tlco 13.127430 1.053687e+02 1.001420e+02 1.416191e+01
## FEV1_FVC_ratio_post 12.568677 7.964519e-01 7.699727e-01 7.192212e-02
## kco 11.247962 1.027795e+02 9.897243e+01 1.278919e+01
## FeNO -3.713975 2.368705e+01 2.550929e+01 1.917285e+01
## Lymphocytes -4.420887 1.916603e+00 1.982802e+00 5.589078e-01
## pd20 -5.602719 1.663281e+03 1.952471e+03 2.619034e+03
## Reversibility -5.933492 6.334717e+00 7.333086e+00 6.681515e+00
## BMI -8.414563 2.616165e+01 2.706171e+01 4.397895e+00
## Eosinophiles -9.402132 1.856754e-01 2.196359e-01 1.300634e-01
## Monocytes -10.868807 3.896472e-01 4.264011e-01 1.312370e-01
## Neutrophiles -11.746058 3.500091e+00 3.856132e+00 1.139378e+00
## pack_years -14.706046 7.390463e+00 1.194451e+01 8.564464e+00
## onset_age_asthma -15.807195 1.557460e+01 2.149024e+01 1.189226e+01
## Age -18.002161 4.351714e+01 4.971821e+01 1.355149e+01
## Basophiles -28.290041 2.631048e-03 3.133509e-02 8.857802e-03
## Overall sd p.value
## tlco 1.816168e+01 2.293066e-39
## FEV1_FVC_ratio_post 9.609862e-02 3.139345e-36
## kco 1.543910e+01 2.370039e-29
## FeNO 2.238045e+01 2.040294e-04
## Lymphocytes 6.830395e-01 9.829654e-06
## pd20 2.354436e+03 2.110148e-08
## Reversibility 7.675073e+00 2.965580e-09
## BMI 4.879071e+00 3.943607e-17
## Eosinophiles 1.647591e-01 5.346873e-21
## Monocytes 1.542493e-01 1.623099e-27
## Neutrophiles 1.382643e+00 7.399067e-32
## pack_years 1.412548e+01 5.895261e-49
## onset_age_asthma 1.707061e+01 2.775530e-56
## Age 1.571245e+01 1.873631e-72
## Basophiles 4.628193e-02 4.582375e-176
##
## $`3`
## v.test Mean in category Overall mean sd in category Overall sd
## Basophiles 38.363542 0.09920477 0.03133509 0.02143379 0.04628193
## Eosinophiles 10.194064 0.28383698 0.21963588 0.18715987 0.16475912
## kco 5.631655 102.29599218 98.97243082 14.11525851 15.43910033
## Monocytes 5.044319 0.45614314 0.42640106 0.13839263 0.15424932
## Lymphocytes 4.965447 2.11244533 1.98280211 0.68818124 0.68303954
## Neutrophiles 4.819239 4.11083499 3.85613193 1.39165051 1.38264302
## FeNO 4.370857 29.24850895 25.50928760 25.82658279 22.38045429
## tlco 3.991800 102.91318840 100.14197170 19.29468011 18.16168128
## pack_years -2.665987 10.50502386 11.94450818 10.28582293 14.12548389
## p.value
## Basophiles 0.000000e+00
## Eosinophiles 2.107659e-24
## kco 1.784880e-08
## Monocytes 4.551398e-07
## Lymphocytes 6.854316e-07
## Neutrophiles 1.441068e-06
## FeNO 1.237596e-05
## tlco 6.557360e-05
## pack_years 7.676275e-03
##
## $`4`
## v.test Mean in category Overall mean sd in category Overall sd
## FeNO 10.902510 198.00000 25.5092876 5.000000 22.3804543
## Eosinophiles 5.412173 0.85000 0.2196359 0.050000 0.1647591
## Reversibility 3.145154 24.39763 7.3330861 6.511456 7.6750733
## p.value
## FeNO 1.121209e-27
## Eosinophiles 6.226434e-08
## Reversibility 1.659993e-031.1.3 Radar Plots
1.1.4 parallel box plots
1.1.5 parallel coordinate plot
1.2 Imporved Deep Empedding Clustering on the encoded data 4 clusters
1.2.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=417) | 1 (N=909) | 2 (N=82) | 3 (N=487) | Total (N=1895) | p value | |
|---|---|---|---|---|---|---|
| Age | < 0.001 | |||||
| Â Â Â Mean (SD) | 63.290 (10.338) | 42.102 (13.015) | 68.061 (8.056) | 49.224 (14.843) | 49.718 (15.717) | |
| Â Â Â Range | 20.000 - 97.000 | 17.000 - 81.000 | 37.000 - 86.000 | 18.000 - 80.000 | 17.000 - 97.000 | |
| Gender | 0.917 | |||||
| Â Â Â No | 163 (39.1%) | 370 (40.7%) | 35 (42.7%) | 196 (40.2%) | 764 (40.3%) | |
| Â Â Â Yes | 254 (60.9%) | 539 (59.3%) | 47 (57.3%) | 291 (59.8%) | 1131 (59.7%) | |
| BMI | < 0.001 | |||||
| Â Â Â Mean (SD) | 28.876 (5.211) | 26.011 (4.343) | 29.310 (5.453) | 27.091 (4.862) | 27.062 (4.880) | |
| Â Â Â Range | 18.290 - 50.058 | 17.029 - 45.265 | 19.195 - 46.475 | 17.509 - 48.919 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | |||||
| Â Â Â Mean (SD) | 35.578 (16.901) | 13.754 (10.154) | 43.756 (19.557) | 20.119 (16.358) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 72.000 | -1.000 - 58.000 | 1.000 - 70.000 | -1.000 - 70.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | |||||
| Â Â Â No | 207 (49.6%) | 690 (75.9%) | 33 (40.2%) | 327 (67.1%) | 1257 (66.3%) | |
| Â Â Â Yes | 210 (50.4%) | 219 (24.1%) | 49 (59.8%) | 160 (32.9%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | |||||
| Â Â Â No | 121 (29.0%) | 344 (37.8%) | 15 (18.3%) | 138 (28.3%) | 618 (32.6%) | |
| Â Â Â Yes | 296 (71.0%) | 565 (62.2%) | 67 (81.7%) | 349 (71.7%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | |||||
| Â Â Â No | 281 (67.4%) | 780 (85.8%) | 38 (46.3%) | 383 (78.6%) | 1482 (78.2%) | |
| Â Â Â Yes | 136 (32.6%) | 129 (14.2%) | 44 (53.7%) | 104 (21.4%) | 413 (21.8%) | |
| dyspenea | < 0.001 | |||||
| Â Â Â No | 260 (62.4%) | 807 (88.8%) | 24 (29.3%) | 391 (80.3%) | 1482 (78.2%) | |
| Â Â Â Yes | 157 (37.6%) | 102 (11.2%) | 58 (70.7%) | 96 (19.7%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | |||||
| Â Â Â No | 274 (65.7%) | 796 (87.6%) | 29 (35.4%) | 375 (77.0%) | 1474 (77.8%) | |
| Â Â Â Yes | 143 (34.3%) | 113 (12.4%) | 53 (64.6%) | 112 (23.0%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.731 (0.099) | 0.800 (0.070) | 0.603 (0.135) | 0.776 (0.088) | 0.770 (0.096) | |
| Â Â Â Range | 0.259 - 0.994 | 0.484 - 1.028 | 0.230 - 0.855 | 0.424 - 1.590 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | |||||
| Â Â Â Mean (SD) | 7.452 (7.655) | 6.336 (6.526) | 15.567 (14.965) | 7.705 (7.013) | 7.333 (7.677) | |
| Â Â Â Range | -20.000 - 45.250 | -26.774 - 56.067 | -12.121 - 77.242 | -4.776 - 46.196 | -26.774 - 77.242 | |
| pd20 | < 0.001 | |||||
| Â Â Â Mean (SD) | 2685.356 (2079.671) | 1604.492 (2652.009) | 2854.609 (1539.427) | 1822.541 (1880.380) | 1952.471 (2355.058) | |
| Â Â Â Range | 0.008 - 13923.750 | -26261.250 - 38775.000 | 57.024 - 5539.290 | -3701.250 - 12925.000 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | |||||
| Â Â Â Mean (SD) | 89.769 (16.151) | 105.898 (13.872) | 72.030 (13.785) | 103.014 (19.384) | 100.142 (18.166) | |
| Â Â Â Range | 44.453 - 165.714 | 67.252 - 230.491 | 44.477 - 106.309 | 44.914 - 389.709 | 44.453 - 389.709 | |
| kco | < 0.001 | |||||
| Â Â Â Mean (SD) | 90.035 (15.095) | 103.298 (12.708) | 76.100 (13.444) | 102.402 (14.105) | 98.972 (15.443) | |
| Â Â Â Range | 43.704 - 139.418 | 69.866 - 144.168 | 40.972 - 117.040 | 53.494 - 149.720 | 40.972 - 149.720 | |
| FeNO | < 0.001 | |||||
| Â Â Â Mean (SD) | 24.947 (22.222) | 23.889 (20.035) | 24.438 (24.503) | 29.196 (25.716) | 25.509 (22.386) | |
| Â Â Â Range | 4.300 - 193.000 | 3.300 - 203.000 | 3.600 - 155.000 | 5.000 - 226.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.217 (0.178) | 0.184 (0.131) | 0.255 (0.171) | 0.283 (0.189) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 2.300 | 0.000 - 0.900 | 0.010 - 0.800 | 0.040 - 1.200 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 4.010 (1.447) | 3.521 (1.160) | 5.320 (1.842) | 4.104 (1.388) | 3.856 (1.383) | |
| Â Â Â Range | 1.300 - 12.300 | 1.100 - 7.900 | 2.200 - 12.500 | 1.000 - 9.710 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | |||||
| Â Â Â Mean (SD) | 1.889 (0.717) | 1.921 (0.569) | 2.459 (1.260) | 2.099 (0.667) | 1.983 (0.683) | |
| Â Â Â Range | 0.300 - 8.000 | 0.600 - 4.800 | 0.900 - 11.200 | 0.700 - 9.400 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.439 (0.157) | 0.388 (0.128) | 0.605 (0.277) | 0.456 (0.139) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 1.100 | 0.200 - 1.000 | 0.200 - 2.400 | 0.200 - 1.100 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.002 (0.010) | 0.003 (0.010) | 0.082 (0.040) | 0.100 (0.021) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.090 | 0.000 - 0.060 | 0.000 - 0.200 | 0.000 - 0.300 | 0.000 - 0.300 | |
| spt_any | < 0.001 | |||||
| Â Â Â No | 198 (47.5%) | 229 (25.2%) | 43 (52.4%) | 177 (36.3%) | 647 (34.1%) | |
| Â Â Â Yes | 219 (52.5%) | 680 (74.8%) | 39 (47.6%) | 310 (63.7%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | |||||
| Â Â Â No | 271 (65.0%) | 387 (42.6%) | 65 (79.3%) | 243 (49.9%) | 966 (51.0%) | |
| Â Â Â Yes | 146 (35.0%) | 522 (57.4%) | 17 (20.7%) | 244 (50.1%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.027 | |||||
| Â Â Â No | 388 (93.0%) | 865 (95.2%) | 72 (87.8%) | 462 (94.9%) | 1787 (94.3%) | |
| Â Â Â Yes | 29 (7.0%) | 44 (4.8%) | 10 (12.2%) | 25 (5.1%) | 108 (5.7%) | |
| nasal_plyposis | 0.012 | |||||
| Â Â Â No | 223 (53.5%) | 550 (60.5%) | 45 (54.9%) | 255 (52.4%) | 1073 (56.6%) | |
| Â Â Â Yes | 194 (46.5%) | 359 (39.5%) | 37 (45.1%) | 232 (47.6%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | |||||
| Â Â Â No | 125 (30.0%) | 337 (37.1%) | 20 (24.4%) | 120 (24.6%) | 602 (31.8%) | |
| Â Â Â Yes | 292 (70.0%) | 572 (62.9%) | 62 (75.6%) | 367 (75.4%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | |||||
| Â Â Â onlys saba or non users | 243 (58.3%) | 672 (73.9%) | 43 (52.4%) | 325 (66.7%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 85 (20.4%) | 142 (15.6%) | 10 (12.2%) | 100 (20.5%) | 337 (17.8%) | |
| Â Â Â step3 | 26 (6.2%) | 49 (5.4%) | 4 (4.9%) | 17 (3.5%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 63 (15.1%) | 46 (5.1%) | 25 (30.5%) | 45 (9.2%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | |||||
| Â Â Â No | 383 (91.8%) | 893 (98.2%) | 62 (75.6%) | 466 (95.7%) | 1804 (95.2%) | |
| Â Â Â Yes | 34 (8.2%) | 16 (1.8%) | 20 (24.4%) | 21 (4.3%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | |||||
| Â Â Â No | 311 (74.6%) | 823 (90.5%) | 46 (56.1%) | 409 (84.0%) | 1589 (83.9%) | |
| Â Â Â Yes | 106 (25.4%) | 86 (9.5%) | 36 (43.9%) | 78 (16.0%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | |||||
| Â Â Â No | 320 (76.7%) | 817 (89.9%) | 48 (58.5%) | 403 (82.8%) | 1588 (83.8%) | |
| Â Â Â Yes | 97 (23.3%) | 92 (10.1%) | 34 (41.5%) | 84 (17.2%) | 307 (16.2%) | |
| gina_control | < 0.001 | |||||
| Â Â Â controlled | 121 (29.0%) | 409 (45.0%) | 9 (11.0%) | 178 (36.6%) | 717 (37.8%) | |
| Â Â Â partially controlled | 223 (53.5%) | 399 (43.9%) | 43 (52.4%) | 227 (46.6%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 73 (17.5%) | 101 (11.1%) | 30 (36.6%) | 82 (16.8%) | 286 (15.1%) | |
| education | < 0.001 | |||||
| Â Â Â primary | 170 (40.8%) | 497 (54.7%) | 12 (14.6%) | 231 (47.4%) | 910 (48.0%) | |
| Â Â Â secondary | 154 (36.9%) | 360 (39.6%) | 33 (40.2%) | 202 (41.5%) | 749 (39.5%) | |
| Â Â Â tertiary | 93 (22.3%) | 52 (5.7%) | 37 (45.1%) | 54 (11.1%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | |||||
| Â Â Â No | 198 (47.5%) | 444 (48.8%) | 42 (51.2%) | 302 (62.0%) | 986 (52.0%) | |
| Â Â Â Yes | 219 (52.5%) | 465 (51.2%) | 40 (48.8%) | 185 (38.0%) | 909 (48.0%) | |
| smoking_status | < 0.001 | |||||
| Â Â Â never smoker | 189 (45.3%) | 570 (62.7%) | 16 (19.5%) | 254 (52.2%) | 1029 (54.3%) | |
| Â Â Â former smokers | 195 (46.8%) | 276 (30.4%) | 43 (52.4%) | 185 (38.0%) | 699 (36.9%) | |
| Â Â Â current smoker | 33 (7.9%) | 63 (6.9%) | 23 (28.0%) | 48 (9.9%) | 167 (8.8%) | |
| pack_years | < 0.001 | |||||
| Â Â Â Mean (SD) | 19.671 (16.531) | 6.904 (8.241) | 38.952 (24.005) | 10.189 (9.810) | 11.945 (14.129) | |
| Â Â Â Range | 0.000 - 90.000 | 0.000 - 69.000 | 0.200 - 112.500 | 0.000 - 48.750 | 0.000 - 112.500 | |
| smoking_exposure_at_home | 0.001 | |||||
| Â Â Â No | 137 (32.9%) | 382 (42.0%) | 22 (26.8%) | 178 (36.6%) | 719 (37.9%) | |
| Â Â Â Yes | 280 (67.1%) | 527 (58.0%) | 60 (73.2%) | 309 (63.4%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | |||||
| Â Â Â No | 214 (51.3%) | 614 (67.5%) | 35 (42.7%) | 286 (58.7%) | 1149 (60.6%) | |
| Â Â Â Yes | 203 (48.7%) | 295 (32.5%) | 47 (57.3%) | 201 (41.3%) | 746 (39.4%) | |
| household_damage | 0.001 | |||||
| Â Â Â No | 384 (92.1%) | 774 (85.1%) | 77 (93.9%) | 422 (86.7%) | 1657 (87.4%) | |
| Â Â Â Yes | 33 (7.9%) | 135 (14.9%) | 5 (6.1%) | 65 (13.3%) | 238 (12.6%) | |
| exertion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 124 (29.7%) | 391 (43.0%) | 27 (32.9%) | 166 (34.1%) | 708 (37.4%) | |
| Â Â Â Yes | 293 (70.3%) | 518 (57.0%) | 55 (67.1%) | 321 (65.9%) | 1187 (62.6%) | |
| infection_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 120 (28.8%) | 417 (45.9%) | 32 (39.0%) | 171 (35.1%) | 740 (39.1%) | |
| Â Â Â Yes | 297 (71.2%) | 492 (54.1%) | 50 (61.0%) | 316 (64.9%) | 1155 (60.9%) | |
| allergen_triggered_asthma | 0.139 | |||||
| Â Â Â No | 286 (68.6%) | 660 (72.6%) | 63 (76.8%) | 332 (68.2%) | 1341 (70.8%) | |
| Â Â Â Yes | 131 (31.4%) | 249 (27.4%) | 19 (23.2%) | 155 (31.8%) | 554 (29.2%) | |
| irritant_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 328 (78.7%) | 806 (88.7%) | 68 (82.9%) | 410 (84.2%) | 1612 (85.1%) | |
| Â Â Â Yes | 89 (21.3%) | 103 (11.3%) | 14 (17.1%) | 77 (15.8%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 259 (62.1%) | 672 (73.9%) | 47 (57.3%) | 312 (64.1%) | 1290 (68.1%) | |
| Â Â Â Yes | 158 (37.9%) | 237 (26.1%) | 35 (42.7%) | 175 (35.9%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 373 (89.4%) | 858 (94.4%) | 72 (87.8%) | 429 (88.1%) | 1732 (91.4%) | |
| Â Â Â Yes | 44 (10.6%) | 51 (5.6%) | 10 (12.2%) | 58 (11.9%) | 163 (8.6%) | |
| XCOPD | < 0.001 | |||||
| Â Â Â No | 319 (76.5%) | 866 (95.3%) | 28 (34.1%) | 442 (90.8%) | 1655 (87.3%) | |
| Â Â Â Yes | 98 (23.5%) | 43 (4.7%) | 54 (65.9%) | 45 (9.2%) | 240 (12.7%) |
1.2.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## XCOPD 4.346409e-67 3
## dyspenea 3.172446e-51 3
## Chronic_productive_cough 7.337022e-37 3
## education 5.015055e-34 6
## Cough 1.191881e-24 3
## Recurrent_wheeze 2.460326e-23 3
## Emergency_last_year 3.266094e-22 3
## Hosptalization_last_year 4.794227e-21 3
## smoking_status 6.460044e-20 6
## familial_allergy 2.687672e-18 3
## severe_asthma 5.019887e-17 3
## spt_any 6.004282e-17 3
## gina_steps 1.070849e-16 9
## gina_control 3.442608e-15 6
## smoking_exposure_at_work 8.517555e-10 3
## infection_triggered_asthma 1.393957e-08 3
## weather_triggered_asthma 2.112933e-06 3
## urbanization_level 7.087766e-06 3
## Ever_rhinitis 1.003099e-05 3
## exertion_triggered_asthma 1.105584e-05 3
## Breathlessness 1.228316e-05 3
## irritant_triggered_asthma 3.395741e-05 3
## emotion_triggered_asthma 1.345500e-04 3
## household_damage 1.168384e-03 3
## smoking_exposure_at_home 1.294261e-03 3
## nasal_plyposis 1.192733e-02 3
## Drug_induced_dyspnea 2.677165e-02 3
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## dyspenea=Yes 38.01453 37.649880 21.794195 2.173218e-17
## Cough=Yes 32.91536 50.359712 33.667546 1.244482e-15
## XCOPD=Yes 40.83333 23.501199 12.664908 1.553951e-12
## familial_allergy=No 28.05383 64.988010 50.976253 7.339633e-11
## education=tertiary 39.40678 22.302158 12.453826 8.459077e-11
## Chronic_productive_cough=Yes 33.96675 34.292566 22.216359 9.457149e-11
## spt_any=No 30.60278 47.482014 34.142480 1.634256e-10
## Recurrent_wheeze=Yes 32.92978 32.613909 21.794195 4.807207e-09
## Emergency_last_year=Yes 34.64052 25.419664 16.147757 2.485836e-08
## infection_triggered_asthma=Yes 25.71429 71.223022 60.949868 8.158405e-07
## smoking_status=former smokers 27.89700 46.762590 36.886544 2.870519e-06
## smoking_exposure_at_work=Yes 27.21180 48.681055 39.366755 1.236932e-05
## severe_asthma=Yes 31.59609 23.261391 16.200528 1.888693e-05
## gina_steps=step4 or 5 35.19553 15.107914 9.445910 2.115506e-05
## irritant_triggered_asthma=Yes 31.44876 21.342926 14.934037 6.007670e-05
## exertion_triggered_asthma=Yes 24.68408 70.263789 62.638522 2.339816e-04
## Hosptalization_last_year=Yes 37.36264 8.153477 4.802111 6.582100e-04
## household_damage=No 23.17441 92.086331 87.440633 7.615644e-04
## gina_control=partially controlled 25.00000 53.477218 47.071240 3.064984e-03
## weather_triggered_asthma=Yes 26.11570 37.889688 31.926121 3.434478e-03
## smoking_exposure_at_home=Yes 23.80952 67.146283 62.058047 1.489124e-02
## urbanization_level=Yes 24.09241 52.517986 47.968338 3.555752e-02
## urbanization_level=No 20.08114 47.482014 52.031662 3.555752e-02
## smoking_exposure_at_home=No 19.05424 32.853717 37.941953 1.489124e-02
## weather_triggered_asthma=No 20.07752 62.110312 68.073879 3.434478e-03
## education=primary 18.68132 40.767386 48.021108 7.779868e-04
## household_damage=Yes 13.86555 7.913669 12.559367 7.615644e-04
## Hosptalization_last_year=No 21.23060 91.846523 95.197889 6.582100e-04
## exertion_triggered_asthma=No 17.51412 29.736211 37.361478 2.339816e-04
## irritant_triggered_asthma=No 20.34739 78.657074 85.065963 6.007670e-05
## smoking_status=never smoker 18.36735 45.323741 54.300792 3.261104e-05
## gina_control=controlled 16.87587 29.016787 37.836412 2.110758e-05
## severe_asthma=No 20.15113 76.738609 83.799472 1.888693e-05
## smoking_exposure_at_work=No 18.62489 51.318945 60.633245 1.236932e-05
## gina_steps=onlys saba or non users 18.93998 58.273381 67.704485 4.412495e-06
## infection_triggered_asthma=No 16.21622 28.776978 39.050132 8.158405e-07
## Emergency_last_year=No 19.57206 74.580336 83.852243 2.485836e-08
## Recurrent_wheeze=No 18.96086 67.386091 78.205805 4.807207e-09
## spt_any=Yes 17.54808 52.517986 65.857520 1.634256e-10
## Chronic_productive_cough=No 18.58887 65.707434 77.783641 9.457149e-11
## familial_allergy=Yes 15.71582 35.011990 49.023747 7.339633e-11
## XCOPD=No 19.27492 76.498801 87.335092 1.553951e-12
## Cough=No 16.46778 49.640288 66.332454 1.244482e-15
## dyspenea=No 17.54386 62.350120 78.205805 2.173218e-17
## v.test
## dyspenea=Yes 8.484139
## Cough=Yes 7.999971
## XCOPD=Yes 7.069587
## familial_allergy=No 6.513548
## education=tertiary 6.492202
## Chronic_productive_cough=Yes 6.475383
## spt_any=No 6.392284
## Recurrent_wheeze=Yes 5.853712
## Emergency_last_year=Yes 5.574260
## infection_triggered_asthma=Yes 4.931540
## smoking_status=former smokers 4.679874
## smoking_exposure_at_work=Yes 4.370975
## severe_asthma=Yes 4.277659
## gina_steps=step4 or 5 4.252338
## irritant_triggered_asthma=Yes 4.012509
## exertion_triggered_asthma=Yes 3.679184
## Hosptalization_last_year=Yes 3.406419
## household_damage=No 3.366399
## gina_control=partially controlled 2.961144
## weather_triggered_asthma=Yes 2.925912
## smoking_exposure_at_home=Yes 2.435013
## urbanization_level=Yes 2.101952
## urbanization_level=No -2.101952
## smoking_exposure_at_home=No -2.435013
## weather_triggered_asthma=No -2.925912
## education=primary -3.360510
## household_damage=Yes -3.366399
## Hosptalization_last_year=No -3.406419
## exertion_triggered_asthma=No -3.679184
## irritant_triggered_asthma=No -4.012509
## smoking_status=never smoker -4.154422
## gina_control=controlled -4.252841
## severe_asthma=No -4.277659
## smoking_exposure_at_work=No -4.370975
## gina_steps=onlys saba or non users -4.590942
## infection_triggered_asthma=No -4.931540
## Emergency_last_year=No -5.574260
## Recurrent_wheeze=No -5.853712
## spt_any=Yes -6.392284
## Chronic_productive_cough=No -6.475383
## familial_allergy=Yes -6.513548
## XCOPD=No -7.069587
## Cough=No -7.999971
## dyspenea=No -8.484139
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## dyspenea=No 54.45344 88.778878 78.205805 1.032629e-27
## XCOPD=No 52.32628 95.269527 87.335092 4.832946e-25
## Chronic_productive_cough=No 54.00271 87.568757 77.783641 1.654897e-23
## Cough=No 54.89260 75.907591 66.332454 1.666732e-17
## spt_any=Yes 54.48718 74.807481 65.857520 2.289895e-15
## Recurrent_wheeze=No 52.63158 85.808581 78.205805 7.809974e-15
## Emergency_last_year=No 51.79358 90.539054 83.852243 1.317236e-14
## smoking_status=never smoker 55.39359 62.706271 54.300792 1.621404e-12
## familial_allergy=Yes 56.18945 57.425743 49.023747 2.033843e-12
## severe_asthma=No 51.44836 89.878988 83.799472 3.030811e-12
## gina_control=controlled 57.04324 44.994499 37.836412 6.869202e-10
## Hosptalization_last_year=No 49.50111 98.239824 95.197889 7.217131e-10
## smoking_exposure_at_work=No 53.43777 67.546755 60.633245 3.152811e-09
## infection_triggered_asthma=No 56.35135 45.874587 39.050132 5.035010e-09
## gina_steps=onlys saba or non users 52.37724 73.927393 67.704485 2.481334e-08
## education=primary 54.61538 54.675468 48.021108 2.578344e-08
## weather_triggered_asthma=No 52.09302 73.927393 68.073879 1.454855e-07
## exertion_triggered_asthma=No 55.22599 43.014301 37.361478 1.054852e-06
## Ever_rhinitis=No 55.98007 37.073707 31.767810 1.938853e-06
## Breathlessness=No 55.66343 37.843784 32.612137 3.150605e-06
## emotion_triggered_asthma=No 49.53811 94.389439 91.398417 6.823074e-06
## irritant_triggered_asthma=No 50.00000 88.668867 85.065963 2.211789e-05
## smoking_exposure_at_home=No 53.12935 42.024202 37.941953 4.433621e-04
## nasal_plyposis=No 51.25815 60.506051 56.622691 1.060596e-03
## household_damage=Yes 56.72269 14.851485 12.559367 3.919264e-03
## urbanization_level=Yes 51.15512 51.155116 47.968338 7.723427e-03
## gina_steps=step 1 or 2 42.13650 15.621562 17.783641 1.811122e-02
## gina_control=partially controlled 44.73094 43.894389 47.071240 7.851925e-03
## urbanization_level=No 45.03043 48.844884 52.031662 7.723427e-03
## smoking_status=current smoker 37.72455 6.930693 8.812665 5.442071e-03
## household_damage=No 46.71092 85.148515 87.440633 3.919264e-03
## nasal_plyposis=Yes 43.67397 39.493949 43.377309 1.060596e-03
## smoking_exposure_at_home=Yes 44.81293 57.975798 62.058047 4.433621e-04
## irritant_triggered_asthma=Yes 36.39576 11.331133 14.934037 2.211789e-05
## emotion_triggered_asthma=Yes 31.28834 5.610561 8.601583 6.823074e-06
## Breathlessness=Yes 44.24432 62.156216 67.387863 3.150605e-06
## gina_control=uncontrolled 35.31469 11.111111 15.092348 2.975807e-06
## Ever_rhinitis=Yes 44.23821 62.926293 68.232190 1.938853e-06
## exertion_triggered_asthma=Yes 43.63943 56.985699 62.638522 1.054852e-06
## weather_triggered_asthma=Yes 39.17355 26.072607 31.926121 1.454855e-07
## smoking_status=former smokers 39.48498 30.363036 36.886544 1.512473e-08
## infection_triggered_asthma=Yes 42.59740 54.125413 60.949868 5.035010e-09
## smoking_exposure_at_work=Yes 39.54424 32.453245 39.366755 3.152811e-09
## Hosptalization_last_year=Yes 17.58242 1.760176 4.802111 7.217131e-10
## gina_steps=step4 or 5 25.69832 5.060506 9.445910 1.737586e-10
## severe_asthma=Yes 29.96743 10.121012 16.200528 3.030811e-12
## familial_allergy=No 40.06211 42.574257 50.976253 2.033843e-12
## Emergency_last_year=Yes 28.10458 9.460946 16.147757 1.317236e-14
## Recurrent_wheeze=Yes 31.23487 14.191419 21.794195 7.809974e-15
## spt_any=No 35.39413 25.192519 34.142480 2.289895e-15
## Cough=Yes 34.32602 24.092409 33.667546 1.666732e-17
## education=tertiary 22.03390 5.720572 12.453826 2.215418e-18
## Chronic_productive_cough=Yes 26.84086 12.431243 22.216359 1.654897e-23
## XCOPD=Yes 17.91667 4.730473 12.664908 4.832946e-25
## dyspenea=Yes 24.69734 11.221122 21.794195 1.032629e-27
## v.test
## dyspenea=No 10.909994
## XCOPD=No 10.336206
## Chronic_productive_cough=No 9.991835
## Cough=No 8.514942
## spt_any=Yes 7.924542
## Recurrent_wheeze=No 7.770625
## Emergency_last_year=No 7.704144
## smoking_status=never smoker 7.063688
## familial_allergy=Yes 7.032144
## severe_asthma=No 6.976288
## gina_control=controlled 6.169072
## Hosptalization_last_year=No 6.161254
## smoking_exposure_at_work=No 5.923437
## infection_triggered_asthma=No 5.846011
## gina_steps=onlys saba or non users 5.574576
## education=primary 5.567895
## weather_triggered_asthma=No 5.258183
## exertion_triggered_asthma=No 4.881120
## Ever_rhinitis=No 4.759695
## Breathlessness=No 4.660749
## emotion_triggered_asthma=No 4.499134
## irritant_triggered_asthma=No 4.242363
## smoking_exposure_at_home=No 3.512829
## nasal_plyposis=No 3.273939
## household_damage=Yes 2.884588
## urbanization_level=Yes 2.663927
## gina_steps=step 1 or 2 -2.363336
## gina_control=partially controlled -2.658372
## urbanization_level=No -2.663927
## smoking_status=current smoker -2.779631
## household_damage=No -2.884588
## nasal_plyposis=Yes -3.273939
## smoking_exposure_at_home=Yes -3.512829
## irritant_triggered_asthma=Yes -4.242363
## emotion_triggered_asthma=Yes -4.499134
## Breathlessness=Yes -4.660749
## gina_control=uncontrolled -4.672483
## Ever_rhinitis=Yes -4.759695
## exertion_triggered_asthma=Yes -4.881120
## weather_triggered_asthma=Yes -5.258183
## smoking_status=former smokers -5.660143
## infection_triggered_asthma=Yes -5.846011
## smoking_exposure_at_work=Yes -5.923437
## Hosptalization_last_year=Yes -6.161254
## gina_steps=step4 or 5 -6.382906
## severe_asthma=Yes -6.976288
## familial_allergy=No -7.032144
## Emergency_last_year=Yes -7.704144
## Recurrent_wheeze=Yes -7.770625
## spt_any=No -7.924542
## Cough=Yes -8.514942
## education=tertiary -8.745749
## Chronic_productive_cough=Yes -9.991835
## XCOPD=Yes -10.336206
## dyspenea=Yes -10.909994
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=Yes 22.500000 65.85366 12.664908 4.360693e-31
## dyspenea=Yes 14.043584 70.73171 21.794195 3.359304e-22
## Chronic_productive_cough=Yes 12.589074 64.63415 22.216359 3.932611e-17
## education=tertiary 15.677966 45.12195 12.453826 5.375905e-14
## Recurrent_wheeze=Yes 10.653753 53.65854 21.794195 1.214720e-10
## Hosptalization_last_year=Yes 21.978022 24.39024 4.802111 3.409612e-10
## Emergency_last_year=Yes 11.764706 43.90244 16.147757 1.215057e-09
## severe_asthma=Yes 11.074919 41.46341 16.200528 2.516517e-08
## gina_steps=step4 or 5 13.966480 30.48780 9.445910 3.803769e-08
## familial_allergy=No 6.728778 79.26829 50.976253 7.892647e-08
## smoking_status=current smoker 13.772455 28.04878 8.812665 2.126229e-07
## Cough=Yes 7.680251 59.75610 33.667546 8.910290e-07
## gina_control=uncontrolled 10.489510 36.58537 15.092348 9.580916e-07
## spt_any=No 6.646059 52.43902 34.142480 5.396105e-04
## smoking_exposure_at_work=Yes 6.300268 57.31707 39.366755 8.491458e-04
## Breathlessness=Yes 5.246672 81.70732 67.387863 3.417913e-03
## smoking_status=former smokers 6.151645 52.43902 36.886544 3.544892e-03
## Drug_induced_dyspnea=Yes 9.259259 12.19512 5.699208 2.146758e-02
## smoking_exposure_at_home=Yes 5.102041 73.17073 62.058047 3.202503e-02
## weather_triggered_asthma=Yes 5.785124 42.68293 31.926121 3.712727e-02
## weather_triggered_asthma=No 3.643411 57.31707 68.073879 3.712727e-02
## smoking_exposure_at_home=No 3.059805 26.82927 37.941953 3.202503e-02
## Drug_induced_dyspnea=No 4.029099 87.80488 94.300792 2.146758e-02
## gina_steps=onlys saba or non users 3.351520 52.43902 67.704485 3.430430e-03
## Breathlessness=No 2.427184 18.29268 32.612137 3.417913e-03
## smoking_exposure_at_work=No 3.046127 42.68293 60.633245 8.491458e-04
## spt_any=Yes 3.125000 47.56098 65.857520 5.396105e-04
## Cough=No 2.625298 40.24390 66.332454 8.910290e-07
## familial_allergy=Yes 1.829925 20.73171 49.023747 7.892647e-08
## gina_control=controlled 1.255230 10.97561 37.836412 3.305737e-08
## severe_asthma=No 3.022670 58.53659 83.799472 2.516517e-08
## Emergency_last_year=No 2.894902 56.09756 83.852243 1.215057e-09
## Hosptalization_last_year=No 3.436807 75.60976 95.197889 3.409612e-10
## Recurrent_wheeze=No 2.564103 46.34146 78.205805 1.214720e-10
## education=primary 1.318681 14.63415 48.021108 1.002690e-10
## smoking_status=never smoker 1.554908 19.51220 54.300792 5.146896e-11
## Chronic_productive_cough=No 1.967436 35.36585 77.783641 3.932611e-17
## dyspenea=No 1.619433 29.26829 78.205805 3.359304e-22
## XCOPD=No 1.691843 34.14634 87.335092 4.360693e-31
## v.test
## XCOPD=Yes 11.595156
## dyspenea=Yes 9.688960
## Chronic_productive_cough=Yes 8.414891
## education=tertiary 7.522450
## Recurrent_wheeze=Yes 6.437482
## Hosptalization_last_year=Yes 6.278907
## Emergency_last_year=Yes 6.078244
## severe_asthma=Yes 5.572124
## gina_steps=step4 or 5 5.499728
## familial_allergy=No 5.369566
## smoking_status=current smoker 5.187949
## Cough=Yes 4.914294
## gina_control=uncontrolled 4.900056
## spt_any=No 3.460282
## smoking_exposure_at_work=Yes 3.336257
## Breathlessness=Yes 2.927416
## smoking_status=former smokers 2.916054
## Drug_induced_dyspnea=Yes 2.299658
## smoking_exposure_at_home=Yes 2.144098
## weather_triggered_asthma=Yes 2.084362
## weather_triggered_asthma=No -2.084362
## smoking_exposure_at_home=No -2.144098
## Drug_induced_dyspnea=No -2.299658
## gina_steps=onlys saba or non users -2.926279
## Breathlessness=No -2.927416
## smoking_exposure_at_work=No -3.336257
## spt_any=Yes -3.460282
## Cough=No -4.914294
## familial_allergy=Yes -5.369566
## gina_control=controlled -5.524421
## severe_asthma=No -5.572124
## Emergency_last_year=No -6.078244
## Hosptalization_last_year=No -6.278907
## Recurrent_wheeze=No -6.437482
## education=primary -6.466545
## smoking_status=never smoker -6.566624
## Chronic_productive_cough=No -8.414891
## dyspenea=No -9.688960
## XCOPD=No -11.595156
##
## $`3`
## Cla/Mod Mod/Cla Global p.value
## urbanization_level=No 30.62880 62.012320 52.031662 2.907778e-07
## Ever_rhinitis=Yes 28.38360 75.359343 68.232190 7.183585e-05
## emotion_triggered_asthma=Yes 35.58282 11.909651 8.601583 3.437763e-03
## XCOPD=No 26.70695 90.759754 87.335092 7.053481e-03
## Breathlessness=Yes 27.32968 71.663244 67.387863 1.893530e-02
## nasal_plyposis=Yes 28.22384 47.638604 43.377309 2.818137e-02
## weather_triggered_asthma=Yes 28.92562 35.934292 31.926121 2.879206e-02
## infection_triggered_asthma=Yes 27.35931 64.887064 60.949868 3.843799e-02
## infection_triggered_asthma=No 23.10811 35.112936 39.050132 3.843799e-02
## weather_triggered_asthma=No 24.18605 64.065708 68.073879 2.879206e-02
## nasal_plyposis=No 23.76514 52.361396 56.622691 2.818137e-02
## Breathlessness=No 22.33010 28.336756 32.612137 1.893530e-02
## XCOPD=Yes 18.75000 9.240246 12.664908 7.053481e-03
## emotion_triggered_asthma=No 24.76905 88.090349 91.398417 3.437763e-03
## Ever_rhinitis=No 19.93355 24.640657 31.767810 7.183585e-05
## urbanization_level=Yes 20.35204 37.987680 47.968338 2.907778e-07
## v.test
## urbanization_level=No 5.129328
## Ever_rhinitis=Yes 3.970122
## emotion_triggered_asthma=Yes 2.925615
## XCOPD=No 2.694309
## Breathlessness=Yes 2.346802
## nasal_plyposis=Yes 2.194752
## weather_triggered_asthma=Yes 2.186322
## infection_triggered_asthma=Yes 2.070153
## infection_triggered_asthma=No -2.070153
## weather_triggered_asthma=No -2.186322
## nasal_plyposis=No -2.194752
## Breathlessness=No -2.346802
## XCOPD=Yes -2.694309
## emotion_triggered_asthma=No -2.925615
## Ever_rhinitis=No -3.970122
## urbanization_level=Yes -5.129328
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Basophiles 0.883931364 0.000000e+00
## Age 0.336104243 1.257756e-167
## onset_age_asthma 0.323673388 5.116090e-160
## pack_years 0.289079149 1.474087e-139
## tlco 0.230072200 7.254911e-107
## kco 0.219050005 4.861901e-101
## FEV1_FVC_ratio_post 0.213642017 3.274438e-98
## Monocytes 0.098610018 2.567345e-42
## Neutrophiles 0.087745900 2.013486e-37
## Eosinophiles 0.062402280 3.041630e-26
## BMI 0.061911004 4.971857e-26
## Reversibility 0.058545809 1.428849e-24
## pd20 0.038935649 3.417014e-16
## Lymphocytes 0.036542642 3.478659e-15
## FeNO 0.009728522 3.482192e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## Age 19.967311 6.329017e+01 4.971821e+01 1.032562e+01
## onset_age_asthma 19.077083 3.557794e+01 2.149024e+01 1.688057e+01
## pack_years 12.644964 1.967132e+01 1.194451e+01 1.651155e+01
## BMI 8.598200 2.887648e+01 2.706171e+01 5.204854e+00
## pd20 7.195647 2.685356e+03 1.952471e+03 2.077175e+03
## Neutrophiles 2.574929 4.010144e+00 3.856132e+00 1.445543e+00
## Lymphocytes -3.164282 1.889305e+00 1.982802e+00 7.157792e-01
## FEV1_FVC_ratio_post -9.332004 7.311781e-01 7.699727e-01 9.878561e-02
## tlco -13.203005 8.976888e+01 1.001420e+02 1.613160e+01
## kco -13.381575 9.003509e+01 9.897243e+01 1.507714e+01
## Basophiles -14.489100 2.326139e-03 3.133509e-02 1.008877e-02
## Overall sd p.value
## Age 1.571245e+01 1.060084e-88
## onset_age_asthma 1.707061e+01 3.915086e-81
## pack_years 1.412548e+01 1.192788e-36
## BMI 4.879071e+00 8.097623e-18
## pd20 2.354436e+03 6.216504e-13
## Neutrophiles 1.382643e+00 1.002608e-02
## Lymphocytes 6.830395e-01 1.554660e-03
## FEV1_FVC_ratio_post 9.609862e-02 1.038877e-20
## tlco 1.816168e+01 8.430410e-40
## kco 1.543910e+01 7.748796e-41
## Basophiles 4.628193e-02 1.419918e-47
##
## $`1`
## v.test Mean in category Overall mean sd in category
## tlco 13.243678 1.058981e+02 1.001420e+02 1.386481e+01
## FEV1_FVC_ratio_post 12.883620 7.996020e-01 7.699727e-01 7.021585e-02
## kco 11.707447 1.032981e+02 9.897243e+01 1.270091e+01
## FeNO -3.026144 2.388850e+01 2.550929e+01 2.002446e+01
## Lymphocytes -3.810408 1.920517e+00 1.982802e+00 5.681935e-01
## Reversibility -5.426583 6.336361e+00 7.333086e+00 6.522800e+00
## pd20 -6.175883 1.604492e+03 1.952471e+03 2.650549e+03
## BMI -9.002738 2.601052e+01 2.706171e+01 4.340391e+00
## Eosinophiles -9.112200 1.837074e-01 2.196359e-01 1.305561e-01
## Neutrophiles -10.140298 3.520605e+00 3.856132e+00 1.159841e+00
## Monocytes -10.325986 3.882838e-01 4.264011e-01 1.275250e-01
## pack_years -14.911438 6.903825e+00 1.194451e+01 8.236915e+00
## onset_age_asthma -18.938177 1.375358e+01 2.149024e+01 1.014877e+01
## Age -20.253991 4.210231e+01 4.971821e+01 1.300780e+01
## Basophiles -25.400951 3.201320e-03 3.133509e-02 1.008131e-02
## Overall sd p.value
## tlco 1.816168e+01 4.908466e-40
## FEV1_FVC_ratio_post 9.609862e-02 5.566243e-38
## kco 1.543910e+01 1.167426e-31
## FeNO 2.238045e+01 2.476940e-03
## Lymphocytes 6.830395e-01 1.387375e-04
## Reversibility 7.675073e+00 5.744311e-08
## pd20 2.354436e+03 6.579485e-10
## BMI 4.879071e+00 2.201566e-19
## Eosinophiles 1.647591e-01 8.072779e-20
## Neutrophiles 1.382643e+00 3.659824e-24
## Monocytes 1.542493e-01 5.376377e-25
## pack_years 1.412548e+01 2.777060e-50
## onset_age_asthma 1.707061e+01 5.527817e-80
## Age 1.571245e+01 3.275951e-91
## Basophiles 4.628193e-02 2.461567e-142
##
## $`2`
## v.test Mean in category Overall mean sd in category
## pack_years 17.696044 3.895183e+01 1.194451e+01 2.385805e+01
## onset_age_asthma 12.072259 4.375610e+01 2.149024e+01 1.943693e+01
## Age 10.804858 6.806098e+01 4.971821e+01 8.006625e+00
## Monocytes 10.723834 6.051220e-01 4.264011e-01 2.749379e-01
## Basophiles 10.097825 8.182927e-02 3.133509e-02 3.975928e-02
## Reversibility 9.928939 1.556664e+01 7.333086e+00 1.487331e+01
## Neutrophiles 9.799183 5.320000e+00 3.856132e+00 1.830863e+00
## Lymphocytes 6.446393 2.458537e+00 1.982802e+00 1.252700e+00
## BMI 4.265797 2.931045e+01 2.706171e+01 5.419180e+00
## pd20 3.546370 2.854609e+03 1.952471e+03 1.530011e+03
## kco -13.711773 7.609972e+01 9.897243e+01 1.336133e+01
## tlco -14.326513 7.202953e+01 1.001420e+02 1.370092e+01
## FEV1_FVC_ratio_post -16.113126 6.026715e-01 7.699727e-01 1.340342e-01
## Overall sd p.value
## pack_years 1.412548e+01 4.498178e-70
## onset_age_asthma 1.707061e+01 1.480139e-33
## Age 1.571245e+01 3.264602e-27
## Monocytes 1.542493e-01 7.867290e-27
## Basophiles 4.628193e-02 5.648090e-24
## Reversibility 7.675073e+00 3.115541e-23
## Neutrophiles 1.382643e+00 1.134995e-22
## Lymphocytes 6.830395e-01 1.145433e-10
## BMI 4.879071e+00 1.991902e-05
## pd20 2.354436e+03 3.905777e-04
## kco 1.543910e+01 8.632225e-43
## tlco 1.816168e+01 1.494377e-46
## FEV1_FVC_ratio_post 9.609862e-02 2.063235e-58
##
## $`3`
## v.test Mean in category Overall mean sd in category
## Basophiles 38.075342 0.1001848 0.03133509 0.0206010
## Eosinophiles 9.792087 0.2826694 0.21963588 0.1883198
## kco 5.686290 102.4024602 98.97243082 14.0906789
## Monocytes 4.961836 0.4563039 0.42640106 0.1391847
## Neutrophiles 4.589262 4.1040452 3.85613193 1.3861706
## Lymphocytes 4.354710 2.0990144 1.98280211 0.6659848
## FeNO 4.216570 29.1963039 25.50928760 25.6891946
## tlco 4.046883 103.0135690 100.14197170 19.3637469
## onset_age_asthma -2.055826 20.1190965 21.49023747 16.3412714
## pack_years -3.180049 10.1894805 11.94450818 9.7998401
## Overall sd p.value
## Basophiles 0.04628193 0.000000e+00
## Eosinophiles 0.16475912 1.217568e-22
## kco 15.43910033 1.298289e-08
## Monocytes 0.15424932 6.982993e-07
## Neutrophiles 1.38264302 4.448167e-06
## Lymphocytes 0.68303954 1.332431e-05
## FeNO 22.38045429 2.480465e-05
## tlco 18.16168128 5.190420e-05
## onset_age_asthma 17.07060566 3.979931e-02
## pack_years 14.12548389 1.472503e-031.2.3 Radar Plots
1.2.4 parallel box plots
1.2.5 parallel coordinate plot
1.3 Imporved Deep Empedding Clustering on the asthmatic encoded data 3 clusters
1.3.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=505) | 1 (N=565) | 2 (N=825) | Total (N=1895) | p value | |
|---|---|---|---|---|---|
| Age | < 0.001 | ||||
| Â Â Â Mean (SD) | 64.099 (9.021) | 50.738 (15.183) | 40.217 (11.932) | 49.718 (15.717) | |
| Â Â Â Range | 38.000 - 97.000 | 18.000 - 83.000 | 17.000 - 76.000 | 17.000 - 97.000 | |
| Gender | 0.814 | ||||
| Â Â Â No | 209 (41.4%) | 223 (39.5%) | 332 (40.2%) | 764 (40.3%) | |
| Â Â Â Yes | 296 (58.6%) | 342 (60.5%) | 493 (59.8%) | 1131 (59.7%) | |
| BMI | < 0.001 | ||||
| Â Â Â Mean (SD) | 27.941 (4.653) | 27.402 (5.034) | 26.290 (4.797) | 27.062 (4.880) | |
| Â Â Â Range | 18.518 - 48.870 | 17.509 - 48.919 | 17.029 - 50.058 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||
| Â Â Â Mean (SD) | 34.000 (18.273) | 21.619 (17.349) | 13.744 (10.193) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 72.000 | -1.000 - 70.000 | -1.000 - 62.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||
| Â Â Â No | 285 (56.4%) | 362 (64.1%) | 610 (73.9%) | 1257 (66.3%) | |
| Â Â Â Yes | 220 (43.6%) | 203 (35.9%) | 215 (26.1%) | 638 (33.7%) | |
| Breathlessness | 0.001 | ||||
| Â Â Â No | 172 (34.1%) | 151 (26.7%) | 295 (35.8%) | 618 (32.6%) | |
| Â Â Â Yes | 333 (65.9%) | 414 (73.3%) | 530 (64.2%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | ||||
| Â Â Â No | 356 (70.5%) | 424 (75.0%) | 702 (85.1%) | 1482 (78.2%) | |
| Â Â Â Yes | 149 (29.5%) | 141 (25.0%) | 123 (14.9%) | 413 (21.8%) | |
| dyspenea | < 0.001 | ||||
| Â Â Â No | 329 (65.1%) | 429 (75.9%) | 724 (87.8%) | 1482 (78.2%) | |
| Â Â Â Yes | 176 (34.9%) | 136 (24.1%) | 101 (12.2%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | ||||
| Â Â Â No | 345 (68.3%) | 414 (73.3%) | 715 (86.7%) | 1474 (77.8%) | |
| Â Â Â Yes | 160 (31.7%) | 151 (26.7%) | 110 (13.3%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.719 (0.111) | 0.764 (0.097) | 0.805 (0.067) | 0.770 (0.096) | |
| Â Â Â Range | 0.230 - 1.006 | 0.340 - 1.590 | 0.548 - 1.028 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||
| Â Â Â Mean (SD) | 8.350 (9.800) | 8.419 (8.013) | 5.967 (5.428) | 7.333 (7.677) | |
| Â Â Â Range | -26.774 - 77.242 | -12.121 - 56.067 | -12.603 - 43.799 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||
| Â Â Â Mean (SD) | 2856.807 (2053.426) | 1831.813 (1846.918) | 1481.540 (2664.830) | 1952.471 (2355.058) | |
| Â Â Â Range | 0.059 - 13923.750 | -3701.250 - 12925.000 | -26261.250 - 38775.000 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||
| Â Â Â Mean (SD) | 87.198 (15.082) | 100.546 (16.215) | 107.788 (16.678) | 100.142 (18.166) | |
| Â Â Â Range | 44.453 - 136.295 | 44.914 - 161.534 | 74.469 - 389.709 | 44.453 - 389.709 | |
| kco | < 0.001 | ||||
| Â Â Â Mean (SD) | 87.975 (14.288) | 100.637 (15.278) | 104.564 (12.500) | 98.972 (15.443) | |
| Â Â Â Range | 40.972 - 139.418 | 52.566 - 149.720 | 62.485 - 144.168 | 40.972 - 149.720 | |
| FeNO | < 0.001 | ||||
| Â Â Â Mean (SD) | 22.551 (16.618) | 29.843 (27.362) | 24.352 (21.236) | 25.509 (22.386) | |
| Â Â Â Range | 3.600 - 155.000 | 4.900 - 203.000 | 3.300 - 226.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.185 (0.125) | 0.297 (0.210) | 0.188 (0.130) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 1.000 | 0.040 - 2.300 | 0.000 - 0.900 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 3.975 (1.420) | 4.228 (1.489) | 3.529 (1.198) | 3.856 (1.383) | |
| Â Â Â Range | 1.300 - 12.500 | 1.000 - 12.300 | 1.100 - 10.600 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | ||||
| Â Â Â Mean (SD) | 1.824 (0.620) | 2.184 (0.847) | 1.942 (0.549) | 1.983 (0.683) | |
| Â Â Â Range | 0.300 - 7.300 | 0.700 - 11.200 | 0.600 - 5.000 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.428 (0.152) | 0.470 (0.147) | 0.396 (0.154) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 1.100 | 0.200 - 1.100 | 0.200 - 2.400 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.007 (0.022) | 0.096 (0.027) | 0.002 (0.008) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.100 | 0.000 - 0.300 | 0.000 - 0.050 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||
| Â Â Â No | 270 (53.5%) | 203 (35.9%) | 174 (21.1%) | 647 (34.1%) | |
| Â Â Â Yes | 235 (46.5%) | 362 (64.1%) | 651 (78.9%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | ||||
| Â Â Â No | 346 (68.5%) | 294 (52.0%) | 326 (39.5%) | 966 (51.0%) | |
| Â Â Â Yes | 159 (31.5%) | 271 (48.0%) | 499 (60.5%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.018 | ||||
| Â Â Â No | 468 (92.7%) | 527 (93.3%) | 792 (96.0%) | 1787 (94.3%) | |
| Â Â Â Yes | 37 (7.3%) | 38 (6.7%) | 33 (4.0%) | 108 (5.7%) | |
| nasal_plyposis | < 0.001 | ||||
| Â Â Â No | 267 (52.9%) | 297 (52.6%) | 509 (61.7%) | 1073 (56.6%) | |
| Â Â Â Yes | 238 (47.1%) | 268 (47.4%) | 316 (38.3%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | ||||
| Â Â Â No | 119 (23.6%) | 145 (25.7%) | 338 (41.0%) | 602 (31.8%) | |
| Â Â Â Yes | 386 (76.4%) | 420 (74.3%) | 487 (59.0%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | ||||
| Â Â Â onlys saba or non users | 319 (63.2%) | 369 (65.3%) | 595 (72.1%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 86 (17.0%) | 114 (20.2%) | 137 (16.6%) | 337 (17.8%) | |
| Â Â Â step3 | 27 (5.3%) | 23 (4.1%) | 46 (5.6%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 73 (14.5%) | 59 (10.4%) | 47 (5.7%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | ||||
| Â Â Â No | 458 (90.7%) | 537 (95.0%) | 809 (98.1%) | 1804 (95.2%) | |
| Â Â Â Yes | 47 (9.3%) | 28 (5.0%) | 16 (1.9%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | ||||
| Â Â Â No | 387 (76.6%) | 466 (82.5%) | 736 (89.2%) | 1589 (83.9%) | |
| Â Â Â Yes | 118 (23.4%) | 99 (17.5%) | 89 (10.8%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | ||||
| Â Â Â No | 393 (77.8%) | 459 (81.2%) | 736 (89.2%) | 1588 (83.8%) | |
| Â Â Â Yes | 112 (22.2%) | 106 (18.8%) | 89 (10.8%) | 307 (16.2%) | |
| gina_control | < 0.001 | ||||
| Â Â Â controlled | 157 (31.1%) | 188 (33.3%) | 372 (45.1%) | 717 (37.8%) | |
| Â Â Â partially controlled | 252 (49.9%) | 273 (48.3%) | 367 (44.5%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 96 (19.0%) | 104 (18.4%) | 86 (10.4%) | 286 (15.1%) | |
| education | < 0.001 | ||||
| Â Â Â primary | 188 (37.2%) | 252 (44.6%) | 470 (57.0%) | 910 (48.0%) | |
| Â Â Â secondary | 197 (39.0%) | 234 (41.4%) | 318 (38.5%) | 749 (39.5%) | |
| Â Â Â tertiary | 120 (23.8%) | 79 (14.0%) | 37 (4.5%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | ||||
| Â Â Â No | 290 (57.4%) | 330 (58.4%) | 366 (44.4%) | 986 (52.0%) | |
| Â Â Â Yes | 215 (42.6%) | 235 (41.6%) | 459 (55.6%) | 909 (48.0%) | |
| smoking_status | < 0.001 | ||||
| Â Â Â never smoker | 194 (38.4%) | 284 (50.3%) | 551 (66.8%) | 1029 (54.3%) | |
| Â Â Â former smokers | 253 (50.1%) | 219 (38.8%) | 227 (27.5%) | 699 (36.9%) | |
| Â Â Â current smoker | 58 (11.5%) | 62 (11.0%) | 47 (5.7%) | 167 (8.8%) | |
| pack_years | < 0.001 | ||||
| Â Â Â Mean (SD) | 21.869 (18.995) | 12.079 (12.016) | 5.777 (6.393) | 11.945 (14.129) | |
| Â Â Â Range | 0.000 - 112.500 | 0.000 - 57.000 | 0.000 - 36.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||
| Â Â Â No | 149 (29.5%) | 200 (35.4%) | 370 (44.8%) | 719 (37.9%) | |
| Â Â Â Yes | 356 (70.5%) | 365 (64.6%) | 455 (55.2%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | ||||
| Â Â Â No | 229 (45.3%) | 331 (58.6%) | 589 (71.4%) | 1149 (60.6%) | |
| Â Â Â Yes | 276 (54.7%) | 234 (41.4%) | 236 (28.6%) | 746 (39.4%) | |
| household_damage | 0.003 | ||||
| Â Â Â No | 463 (91.7%) | 490 (86.7%) | 704 (85.3%) | 1657 (87.4%) | |
| Â Â Â Yes | 42 (8.3%) | 75 (13.3%) | 121 (14.7%) | 238 (12.6%) | |
| exertion_triggered_asthma | 0.056 | ||||
| Â Â Â No | 197 (39.0%) | 188 (33.3%) | 323 (39.2%) | 708 (37.4%) | |
| Â Â Â Yes | 308 (61.0%) | 377 (66.7%) | 502 (60.8%) | 1187 (62.6%) | |
| infection_triggered_asthma | 0.019 | ||||
| Â Â Â No | 196 (38.8%) | 196 (34.7%) | 348 (42.2%) | 740 (39.1%) | |
| Â Â Â Yes | 309 (61.2%) | 369 (65.3%) | 477 (57.8%) | 1155 (60.9%) | |
| allergen_triggered_asthma | 0.073 | ||||
| Â Â Â No | 377 (74.7%) | 388 (68.7%) | 576 (69.8%) | 1341 (70.8%) | |
| Â Â Â Yes | 128 (25.3%) | 177 (31.3%) | 249 (30.2%) | 554 (29.2%) | |
| irritant_triggered_asthma | 0.042 | ||||
| Â Â Â No | 416 (82.4%) | 476 (84.2%) | 720 (87.3%) | 1612 (85.1%) | |
| Â Â Â Yes | 89 (17.6%) | 89 (15.8%) | 105 (12.7%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 330 (65.3%) | 361 (63.9%) | 599 (72.6%) | 1290 (68.1%) | |
| Â Â Â Yes | 175 (34.7%) | 204 (36.1%) | 226 (27.4%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 459 (90.9%) | 495 (87.6%) | 778 (94.3%) | 1732 (91.4%) | |
| Â Â Â Yes | 46 (9.1%) | 70 (12.4%) | 47 (5.7%) | 163 (8.6%) | |
| XCOPD | < 0.001 | ||||
| Â Â Â No | 380 (75.2%) | 489 (86.5%) | 786 (95.3%) | 1655 (87.3%) | |
| Â Â Â Yes | 125 (24.8%) | 76 (13.5%) | 39 (4.7%) | 240 (12.7%) |
1.3.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## spt_any 1.109287e-32 2
## education 1.154556e-25 4
## XCOPD 1.742767e-25 2
## familial_allergy 1.073373e-23 2
## smoking_status 1.129034e-22 4
## dyspenea 1.170291e-21 2
## smoking_exposure_at_work 2.279392e-20 2
## Chronic_productive_cough 4.885926e-16 2
## Ever_rhinitis 3.078090e-13 2
## Cough 1.852081e-10 2
## Recurrent_wheeze 2.969858e-10 2
## gina_control 6.300168e-09 4
## Emergency_last_year 6.424078e-09 2
## Hosptalization_last_year 8.208974e-09 2
## urbanization_level 3.185819e-08 2
## severe_asthma 4.520928e-08 2
## smoking_exposure_at_home 5.229905e-08 2
## gina_steps 4.491918e-06 6
## emotion_triggered_asthma 6.346964e-05 2
## nasal_plyposis 4.696292e-04 2
## weather_triggered_asthma 8.813531e-04 2
## Breathlessness 1.427406e-03 2
## household_damage 2.637609e-03 2
## Drug_induced_dyspnea 1.805404e-02 2
## infection_triggered_asthma 1.902635e-02 2
## irritant_triggered_asthma 4.208475e-02 2
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## spt_any=No 41.73107 53.465347 34.142480 8.260297e-26
## familial_allergy=No 35.81781 68.514851 50.976253 1.658410e-20
## XCOPD=Yes 52.08333 24.752475 12.664908 2.044360e-19
## education=tertiary 50.84746 23.762376 12.453826 1.858749e-17
## smoking_exposure_at_work=Yes 36.99732 54.653465 39.366755 4.080278e-16
## dyspenea=Yes 42.61501 34.851485 21.794195 1.047688e-15
## smoking_status=former smokers 36.19456 50.099010 36.886544 1.224222e-12
## Chronic_productive_cough=Yes 38.00475 31.683168 22.216359 5.884456e-09
## Cough=Yes 34.48276 43.564356 33.667546 5.797986e-08
## Hosptalization_last_year=Yes 51.64835 9.306931 4.802111 2.230682e-07
## Emergency_last_year=Yes 38.56209 23.366337 16.147757 6.100874e-07
## Recurrent_wheeze=Yes 36.07748 29.504950 21.794195 1.674463e-06
## Ever_rhinitis=Yes 29.85305 76.435644 68.232190 2.656651e-06
## smoking_exposure_at_home=Yes 30.27211 70.495050 62.058047 4.095483e-06
## gina_steps=step4 or 5 40.78212 14.455446 9.445910 1.586663e-05
## severe_asthma=Yes 36.48208 22.178218 16.200528 3.409686e-05
## household_damage=No 27.94206 91.683168 87.440633 5.328088e-04
## urbanization_level=No 29.41176 57.425743 52.031662 4.606036e-03
## gina_control=uncontrolled 33.56643 19.009901 15.092348 4.872444e-03
## smoking_status=current smoker 34.73054 11.485149 8.812665 1.579643e-02
## allergen_triggered_asthma=No 28.11335 74.653465 70.765172 2.408408e-02
## nasal_plyposis=Yes 28.95377 47.128713 43.377309 4.761052e-02
## nasal_plyposis=No 24.88350 52.871287 56.622691 4.761052e-02
## allergen_triggered_asthma=Yes 23.10469 25.346535 29.234828 2.408408e-02
## gina_steps=onlys saba or non users 24.86360 63.168317 67.704485 1.151398e-02
## urbanization_level=Yes 23.65237 42.574257 47.968338 4.606036e-03
## household_damage=Yes 17.64706 8.316832 12.559367 5.328088e-04
## gina_control=controlled 21.89679 31.089109 37.836412 2.372827e-04
## severe_asthma=No 24.74811 77.821782 83.799472 3.409686e-05
## smoking_exposure_at_home=No 20.72323 29.504950 37.941953 4.095483e-06
## Ever_rhinitis=No 19.76744 23.564356 31.767810 2.656651e-06
## Recurrent_wheeze=No 24.02159 70.495050 78.205805 1.674463e-06
## Emergency_last_year=No 24.35494 76.633663 83.852243 6.100874e-07
## Hosptalization_last_year=No 25.38803 90.693069 95.197889 2.230682e-07
## Cough=No 22.67303 56.435644 66.332454 5.797986e-08
## education=primary 20.65934 37.227723 48.021108 1.286630e-08
## Chronic_productive_cough=No 23.40570 68.316832 77.783641 5.884456e-09
## dyspenea=No 22.19973 65.148515 78.205805 1.047688e-15
## smoking_exposure_at_work=No 19.93037 45.346535 60.633245 4.080278e-16
## smoking_status=never smoker 18.85326 38.415842 54.300792 6.180316e-17
## XCOPD=No 22.96073 75.247525 87.335092 2.044360e-19
## familial_allergy=Yes 17.11518 31.485149 49.023747 1.658410e-20
## spt_any=Yes 18.83013 46.534653 65.857520 8.260297e-26
## v.test
## spt_any=No 10.504220
## familial_allergy=No 9.282312
## XCOPD=Yes 9.010866
## education=tertiary 8.502297
## smoking_exposure_at_work=Yes 8.136155
## dyspenea=Yes 8.021139
## smoking_status=former smokers 7.102610
## Chronic_productive_cough=Yes 5.820009
## Cough=Yes 5.424922
## Hosptalization_last_year=Yes 5.179009
## Emergency_last_year=Yes 4.987996
## Recurrent_wheeze=Yes 4.789201
## Ever_rhinitis=Yes 4.695723
## smoking_exposure_at_home=Yes 4.606477
## gina_steps=step4 or 5 4.316300
## severe_asthma=Yes 4.144222
## household_damage=No 3.463696
## urbanization_level=No 2.833368
## gina_control=uncontrolled 2.815348
## smoking_status=current smoker 2.413585
## allergen_triggered_asthma=No 2.255785
## nasal_plyposis=Yes 1.980828
## nasal_plyposis=No -1.980828
## allergen_triggered_asthma=Yes -2.255785
## gina_steps=onlys saba or non users -2.526700
## urbanization_level=Yes -2.833368
## household_damage=Yes -3.463696
## gina_control=controlled -3.675609
## severe_asthma=No -4.144222
## smoking_exposure_at_home=No -4.606477
## Ever_rhinitis=No -4.695723
## Recurrent_wheeze=No -4.789201
## Emergency_last_year=No -4.987996
## Hosptalization_last_year=No -5.179009
## Cough=No -5.424922
## education=primary -5.687831
## Chronic_productive_cough=No -5.820009
## dyspenea=No -8.021139
## smoking_exposure_at_work=No -8.136155
## smoking_status=never smoker -8.361734
## XCOPD=No -9.010866
## familial_allergy=Yes -9.282312
## spt_any=Yes -10.504220
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## Ever_rhinitis=Yes 32.48260 74.33628 68.232190 0.0001735557
## emotion_triggered_asthma=Yes 42.94479 12.38938 8.601583 0.0002035320
## urbanization_level=No 33.46856 58.40708 52.031662 0.0002912019
## Breathlessness=Yes 32.41973 73.27434 67.387863 0.0003281008
## Chronic_productive_cough=Yes 35.86698 26.72566 22.216359 0.0023718786
## gina_control=uncontrolled 36.36364 18.40708 15.092348 0.0096687136
## infection_triggered_asthma=Yes 31.94805 65.30973 60.949868 0.0110301161
## weather_triggered_asthma=Yes 33.71901 36.10619 31.926121 0.0114795186
## exertion_triggered_asthma=Yes 31.76074 66.72566 62.638522 0.0162441240
## nasal_plyposis=Yes 32.60341 47.43363 43.377309 0.0205491263
## Recurrent_wheeze=Yes 34.14044 24.95575 21.794195 0.0312854502
## smoking_status=current smoker 37.12575 10.97345 8.812665 0.0336714365
## Recurrent_wheeze=No 28.60999 75.04425 78.205805 0.0312854502
## smoking_status=never smoker 27.59961 50.26549 54.300792 0.0218040396
## nasal_plyposis=No 27.67940 52.56637 56.622691 0.0205491263
## exertion_triggered_asthma=No 26.55367 33.27434 37.361478 0.0162441240
## weather_triggered_asthma=No 27.98450 63.89381 68.073879 0.0114795186
## infection_triggered_asthma=No 26.48649 34.69027 39.050132 0.0110301161
## gina_control=controlled 26.22036 33.27434 37.836412 0.0074206976
## Chronic_productive_cough=No 28.08684 73.27434 77.783641 0.0023718786
## Breathlessness=No 24.43366 26.72566 32.612137 0.0003281008
## urbanization_level=Yes 25.85259 41.59292 47.968338 0.0002912019
## emotion_triggered_asthma=No 28.57968 87.61062 91.398417 0.0002035320
## Ever_rhinitis=No 24.08638 25.66372 31.767810 0.0001735557
## v.test
## Ever_rhinitis=Yes 3.754691
## emotion_triggered_asthma=Yes 3.714592
## urbanization_level=No 3.623003
## Breathlessness=Yes 3.592039
## Chronic_productive_cough=Yes 3.039225
## gina_control=uncontrolled 2.587457
## infection_triggered_asthma=Yes 2.541743
## weather_triggered_asthma=Yes 2.527753
## exertion_triggered_asthma=Yes 2.403384
## nasal_plyposis=Yes 2.316167
## Recurrent_wheeze=Yes 2.153423
## smoking_status=current smoker 2.123985
## Recurrent_wheeze=No -2.153423
## smoking_status=never smoker -2.293764
## nasal_plyposis=No -2.316167
## exertion_triggered_asthma=No -2.403384
## weather_triggered_asthma=No -2.527753
## infection_triggered_asthma=No -2.541743
## gina_control=controlled -2.677350
## Chronic_productive_cough=No -3.039225
## Breathlessness=No -3.592039
## urbanization_level=Yes -3.623003
## emotion_triggered_asthma=No -3.714592
## Ever_rhinitis=No -3.754691
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## spt_any=Yes 52.16346 78.909091 65.857520 1.417676e-26
## smoking_status=never smoker 53.54713 66.787879 54.300792 5.922709e-22
## XCOPD=No 47.49245 95.272727 87.335092 1.144005e-21
## dyspenea=No 48.85290 87.757576 78.205805 1.544963e-19
## familial_allergy=Yes 53.71367 60.484848 49.023747 1.594075e-18
## smoking_exposure_at_work=No 51.26197 71.393939 60.633245 2.356497e-17
## Chronic_productive_cough=No 48.50746 86.666667 77.783641 8.596556e-17
## Ever_rhinitis=No 56.14618 40.969697 31.767810 4.971629e-14
## education=primary 51.64835 56.969697 48.021108 7.365745e-12
## Recurrent_wheeze=No 47.36842 85.090909 78.205805 1.077270e-10
## Cough=No 48.52824 73.939394 66.332454 6.114451e-10
## urbanization_level=Yes 50.49505 55.636364 47.968338 4.431318e-09
## gina_control=controlled 51.88285 45.090909 37.836412 1.157891e-08
## severe_asthma=No 46.34761 89.212121 83.799472 1.210151e-08
## Emergency_last_year=No 46.31844 89.212121 83.852243 1.611384e-08
## smoking_exposure_at_home=No 51.46036 44.848485 37.941953 5.663677e-08
## Hosptalization_last_year=No 44.84479 98.060606 95.197889 9.572743e-08
## emotion_triggered_asthma=No 44.91917 94.303030 91.398417 5.871353e-05
## nasal_plyposis=No 47.43709 61.696970 56.622691 8.999578e-05
## weather_triggered_asthma=No 46.43411 72.606061 68.073879 1.952925e-04
## gina_steps=onlys saba or non users 46.37568 72.121212 67.704485 2.964720e-04
## Drug_induced_dyspnea=No 44.32009 96.000000 94.300792 4.679742e-03
## Breathlessness=No 47.73463 35.757576 32.612137 1.051218e-02
## infection_triggered_asthma=No 47.02703 42.181818 39.050132 1.431025e-02
## household_damage=Yes 50.84034 14.666667 12.559367 1.564568e-02
## irritant_triggered_asthma=No 44.66501 87.272727 85.065963 1.763772e-02
## gina_control=partially controlled 41.14350 44.484848 47.071240 4.779942e-02
## irritant_triggered_asthma=Yes 37.10247 12.727273 14.934037 1.763772e-02
## household_damage=No 42.48642 85.333333 87.440633 1.564568e-02
## infection_triggered_asthma=Yes 41.29870 57.818182 60.949868 1.431025e-02
## Breathlessness=Yes 41.50352 64.242424 67.387863 1.051218e-02
## Drug_induced_dyspnea=Yes 30.55556 4.000000 5.699208 4.679742e-03
## weather_triggered_asthma=Yes 37.35537 27.393939 31.926121 1.952925e-04
## nasal_plyposis=Yes 38.44282 38.303030 43.377309 8.999578e-05
## emotion_triggered_asthma=Yes 28.83436 5.696970 8.601583 5.871353e-05
## smoking_status=current smoker 28.14371 5.696970 8.812665 1.963597e-05
## gina_steps=step4 or 5 26.25698 5.696970 9.445910 5.760520e-07
## gina_control=uncontrolled 30.06993 10.424242 15.092348 4.432761e-07
## Hosptalization_last_year=Yes 17.58242 1.939394 4.802111 9.572743e-08
## smoking_exposure_at_home=Yes 38.69048 55.151515 62.058047 5.663677e-08
## Emergency_last_year=Yes 29.08497 10.787879 16.147757 1.611384e-08
## severe_asthma=Yes 28.99023 10.787879 16.200528 1.210151e-08
## urbanization_level=No 37.11968 44.363636 52.031662 4.431318e-09
## Cough=Yes 33.69906 26.060606 33.667546 6.114451e-10
## Recurrent_wheeze=Yes 29.78208 14.909091 21.794195 1.077270e-10
## smoking_status=former smokers 32.47496 27.515152 36.886544 7.969410e-14
## Ever_rhinitis=Yes 37.66435 59.030303 68.232190 4.971629e-14
## Chronic_productive_cough=Yes 26.12827 13.333333 22.216359 8.596556e-17
## smoking_exposure_at_work=Yes 31.63539 28.606061 39.366755 2.356497e-17
## familial_allergy=No 33.74741 39.515152 50.976253 1.594075e-18
## dyspenea=Yes 24.45521 12.242424 21.794195 1.544963e-19
## XCOPD=Yes 16.25000 4.727273 12.664908 1.144005e-21
## education=tertiary 15.67797 4.484848 12.453826 3.321253e-22
## spt_any=No 26.89335 21.090909 34.142480 1.417676e-26
## v.test
## spt_any=Yes 10.669249
## smoking_status=never smoker 9.630868
## XCOPD=No 9.562992
## dyspenea=No 9.041528
## familial_allergy=Yes 8.782833
## smoking_exposure_at_work=No 8.474718
## Chronic_productive_cough=No 8.322722
## Ever_rhinitis=No 7.532662
## education=primary 6.850373
## Recurrent_wheeze=No 6.455690
## Cough=No 6.187452
## urbanization_level=Yes 5.867231
## gina_control=controlled 5.705813
## severe_asthma=No 5.698290
## Emergency_last_year=No 5.649262
## smoking_exposure_at_home=No 5.429107
## Hosptalization_last_year=No 5.334653
## emotion_triggered_asthma=No 4.017922
## nasal_plyposis=No 3.916092
## weather_triggered_asthma=No 3.725029
## gina_steps=onlys saba or non users 3.618363
## Drug_induced_dyspnea=No 2.828290
## Breathlessness=No 2.558510
## infection_triggered_asthma=No 2.449380
## household_damage=Yes 2.417078
## irritant_triggered_asthma=No 2.373137
## gina_control=partially controlled -1.979147
## irritant_triggered_asthma=Yes -2.373137
## household_damage=No -2.417078
## infection_triggered_asthma=Yes -2.449380
## Breathlessness=Yes -2.558510
## Drug_induced_dyspnea=Yes -2.828290
## weather_triggered_asthma=Yes -3.725029
## nasal_plyposis=Yes -3.916092
## emotion_triggered_asthma=Yes -4.017922
## smoking_status=current smoker -4.268990
## gina_steps=step4 or 5 -4.999078
## gina_control=uncontrolled -5.049367
## Hosptalization_last_year=Yes -5.334653
## smoking_exposure_at_home=Yes -5.429107
## Emergency_last_year=Yes -5.649262
## severe_asthma=Yes -5.698290
## urbanization_level=No -5.867231
## Cough=Yes -6.187452
## Recurrent_wheeze=Yes -6.455690
## smoking_status=former smokers -7.470824
## Ever_rhinitis=Yes -7.532662
## Chronic_productive_cough=Yes -8.322722
## smoking_exposure_at_work=Yes -8.474718
## familial_allergy=No -8.782833
## dyspenea=Yes -9.041528
## XCOPD=Yes -9.562992
## education=tertiary -9.690124
## spt_any=No -10.669249
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Basophiles 0.82738931 0.000000e+00
## Age 0.38368088 1.432644e-199
## onset_age_asthma 0.23277108 1.377264e-109
## pack_years 0.21458766 5.786900e-100
## tlco 0.21266399 5.854208e-99
## kco 0.19576744 3.097710e-90
## FEV1_FVC_ratio_post 0.13341830 1.471641e-59
## Eosinophiles 0.09261362 1.178898e-40
## pd20 0.05751640 4.602721e-25
## Neutrophiles 0.04789098 6.880168e-21
## Lymphocytes 0.04170545 3.148268e-18
## Monocytes 0.04009889 1.535550e-17
## Reversibility 0.02444252 6.810951e-11
## BMI 0.02099153 1.923003e-09
## FeNO 0.01700018 9.027199e-08
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## Age 24.008642 6.409901e+01 4.971821e+01 9.012318e+00
## onset_age_asthma 19.223321 3.400000e+01 2.149024e+01 1.825539e+01
## pack_years 18.431076 2.186940e+01 1.194451e+01 1.897651e+01
## pd20 10.075608 2.856807e+03 1.952471e+03 2.051392e+03
## BMI 4.728294 2.794116e+01 2.706171e+01 4.648757e+00
## Reversibility 3.476116 8.350151e+00 7.333086e+00 9.790633e+00
## Neutrophiles 2.247490 3.974594e+00 3.856132e+00 1.418854e+00
## FeNO -3.467842 2.255059e+01 2.550929e+01 1.660151e+01
## Eosinophiles -5.449856 1.854059e-01 2.196359e-01 1.247218e-01
## Lymphocytes -6.091876 1.824178e+00 1.982802e+00 6.197574e-01
## FEV1_FVC_ratio_post -13.792015 7.194465e-01 7.699727e-01 1.104921e-01
## Basophiles -13.876892 6.851485e-03 3.133509e-02 2.222717e-02
## kco -18.684455 8.797543e+01 9.897243e+01 1.427402e+01
## tlco -18.694922 8.719848e+01 1.001420e+02 1.506704e+01
## Overall sd p.value
## Age 1.571245e+01 2.259002e-127
## onset_age_asthma 1.707061e+01 2.361611e-82
## pack_years 1.412548e+01 7.399714e-76
## pd20 2.354436e+03 7.082146e-24
## BMI 4.879071e+00 2.264146e-06
## Reversibility 7.675073e+00 5.087330e-04
## Neutrophiles 1.382643e+00 2.460873e-02
## FeNO 2.238045e+01 5.246547e-04
## Eosinophiles 1.647591e-01 5.041071e-08
## Lymphocytes 6.830395e-01 1.115953e-09
## FEV1_FVC_ratio_post 9.609862e-02 2.846940e-43
## Basophiles 4.628193e-02 8.745403e-44
## kco 1.543910e+01 6.625159e-78
## tlco 1.816168e+01 5.444986e-78
##
## $`1`
## v.test Mean in category Overall mean sd in category
## Basophiles 39.545184 0.09585841 0.03133509 0.02663116
## Eosinophiles 13.241509 0.29654867 0.21963588 0.20962744
## Lymphocytes 8.344350 2.18373451 1.98280211 0.84667284
## Monocytes 7.932916 0.46953982 0.42640106 0.14655864
## Neutrophiles 7.627904 4.22794690 3.85613193 1.48776367
## FeNO 5.492632 29.84300885 25.50928760 27.33807112
## Reversibility 4.013106 8.41894853 7.33308613 8.00589501
## kco 3.059067 100.63746273 98.97243082 15.26417525
## BMI 1.978530 27.40202830 27.06170516 5.02948191
## Overall sd p.value
## Basophiles 0.04628193 0.000000e+00
## Eosinophiles 0.16475912 5.052313e-40
## Lymphocytes 0.68303954 7.160654e-17
## Monocytes 0.15424932 2.140588e-15
## Neutrophiles 1.38264302 2.386016e-14
## FeNO 22.38045429 3.959884e-08
## Reversibility 7.67507328 5.992493e-05
## kco 15.43910033 2.220276e-03
## BMI 4.87907144 4.786892e-02
##
## $`2`
## v.test Mean in category Overall mean sd in category
## tlco 16.088042 1.077880e+02 1.001420e+02 1.666771e+01
## FEV1_FVC_ratio_post 14.005906 8.051938e-01 7.699727e-01 6.694671e-02
## kco 13.839112 1.045636e+02 9.897243e+01 1.249192e+01
## FeNO -1.975324 2.435242e+01 2.550929e+01 2.122301e+01
## Lymphocytes -2.266493 1.942291e+00 1.982802e+00 5.485343e-01
## BMI -6.041836 2.629030e+01 2.706171e+01 4.793755e+00
## Reversibility -6.802406 5.966868e+00 7.333086e+00 5.424856e+00
## Eosinophiles -7.357306 1.879152e-01 2.196359e-01 1.302353e-01
## Monocytes -7.498624 3.961333e-01 4.264011e-01 1.538845e-01
## pd20 -7.643556 1.481540e+03 1.952471e+03 2.663214e+03
## Neutrophiles -9.041949 3.528982e+00 3.856132e+00 1.196939e+00
## pack_years -16.685548 5.776872e+00 1.194451e+01 6.389474e+00
## onset_age_asthma -17.340170 1.374424e+01 2.149024e+01 1.018692e+01
## Age -23.107946 4.021697e+01 4.971821e+01 1.192462e+01
## Basophiles -24.111411 2.133333e-03 3.133509e-02 7.819582e-03
## Overall sd p.value
## tlco 1.816168e+01 3.094708e-58
## FEV1_FVC_ratio_post 9.609862e-02 1.434380e-44
## kco 1.543910e+01 1.480247e-43
## FeNO 2.238045e+01 4.823144e-02
## Lymphocytes 6.830395e-01 2.342123e-02
## BMI 4.879071e+00 1.523703e-09
## Reversibility 7.675073e+00 1.028864e-11
## Eosinophiles 1.647591e-01 1.876588e-13
## Monocytes 1.542493e-01 6.449141e-14
## pd20 2.354436e+03 2.113035e-14
## Neutrophiles 1.382643e+00 1.539022e-19
## pack_years 1.412548e+01 1.669666e-62
## onset_age_asthma 1.707061e+01 2.340426e-67
## Age 1.571245e+01 3.852158e-118
## Basophiles 4.628193e-02 1.897674e-1281.3.3 Radar Plots
1.3.4 parallel box plots
1.3.5 parallel coordinate plot
1.4 Deep Empedding Clustering on the encoded data 5 clusters
1.4.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=242) | 1 (N=367) | 2 (N=347) | 3 (N=512) | 4 (N=427) | Total (N=1895) | p value | |
|---|---|---|---|---|---|---|---|
| Age | < 0.001 | ||||||
| Â Â Â Mean (SD) | 48.149 (14.434) | 43.439 (11.414) | 65.107 (9.273) | 35.619 (9.922) | 60.405 (9.941) | 49.718 (15.717) | |
| Â Â Â Range | 18.000 - 82.000 | 19.000 - 73.000 | 28.000 - 86.000 | 17.000 - 65.000 | 31.000 - 97.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | ||||||
| Â Â Â No | 137 (56.6%) | 110 (30.0%) | 122 (35.2%) | 208 (40.6%) | 187 (43.8%) | 764 (40.3%) | |
| Â Â Â Yes | 105 (43.4%) | 257 (70.0%) | 225 (64.8%) | 304 (59.4%) | 240 (56.2%) | 1131 (59.7%) | |
| BMI | < 0.001 | ||||||
| Â Â Â Mean (SD) | 25.506 (3.570) | 31.224 (5.336) | 28.690 (5.009) | 24.431 (3.321) | 26.197 (3.619) | 27.062 (4.880) | |
| Â Â Â Range | 18.084 - 38.955 | 19.919 - 50.058 | 17.603 - 47.199 | 17.029 - 33.951 | 17.509 - 42.187 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||||
| Â Â Â Mean (SD) | 19.955 (16.718) | 15.779 (11.759) | 33.671 (19.649) | 12.041 (8.340) | 28.700 (17.680) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 70.000 | -1.000 - 50.000 | 1.000 - 70.000 | -1.000 - 42.000 | 1.000 - 72.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||||
| Â Â Â No | 190 (78.5%) | 245 (66.8%) | 150 (43.2%) | 398 (77.7%) | 274 (64.2%) | 1257 (66.3%) | |
| Â Â Â Yes | 52 (21.5%) | 122 (33.2%) | 197 (56.8%) | 114 (22.3%) | 153 (35.8%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | ||||||
| Â Â Â No | 28 (11.6%) | 82 (22.3%) | 85 (24.5%) | 237 (46.3%) | 186 (43.6%) | 618 (32.6%) | |
| Â Â Â Yes | 214 (88.4%) | 285 (77.7%) | 262 (75.5%) | 275 (53.7%) | 241 (56.4%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | ||||||
| Â Â Â No | 177 (73.1%) | 254 (69.2%) | 195 (56.2%) | 485 (94.7%) | 371 (86.9%) | 1482 (78.2%) | |
| Â Â Â Yes | 65 (26.9%) | 113 (30.8%) | 152 (43.8%) | 27 (5.3%) | 56 (13.1%) | 413 (21.8%) | |
| dyspenea | < 0.001 | ||||||
| Â Â Â No | 211 (87.2%) | 265 (72.2%) | 157 (45.2%) | 478 (93.4%) | 371 (86.9%) | 1482 (78.2%) | |
| Â Â Â Yes | 31 (12.8%) | 102 (27.8%) | 190 (54.8%) | 34 (6.6%) | 56 (13.1%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | ||||||
| Â Â Â No | 196 (81.0%) | 291 (79.3%) | 189 (54.5%) | 466 (91.0%) | 332 (77.8%) | 1474 (77.8%) | |
| Â Â Â Yes | 46 (19.0%) | 76 (20.7%) | 158 (45.5%) | 46 (9.0%) | 95 (22.2%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.746 (0.103) | 0.805 (0.075) | 0.689 (0.116) | 0.822 (0.055) | 0.757 (0.074) | 0.770 (0.096) | |
| Â Â Â Range | 0.259 - 1.005 | 0.541 - 1.590 | 0.230 - 0.994 | 0.640 - 0.991 | 0.474 - 1.006 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||||
| Â Â Â Mean (SD) | 13.993 (11.782) | 6.199 (5.592) | 9.546 (8.867) | 4.884 (4.062) | 5.671 (5.719) | 7.333 (7.677) | |
| Â Â Â Range | -12.121 - 77.242 | -26.774 - 30.890 | -6.858 - 55.102 | -12.603 - 26.316 | -20.000 - 29.487 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||||
| Â Â Â Mean (SD) | 1385.852 (1650.423) | 978.765 (1214.191) | 2639.095 (1758.006) | 1746.502 (3124.610) | 2799.472 (2340.208) | 1952.471 (2355.058) | |
| Â Â Â Range | -2562.590 - 9693.750 | -6521.250 - 9693.750 | 0.059 - 9693.750 | -26261.250 - 38775.000 | -3701.250 - 19387.500 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||||
| Â Â Â Mean (SD) | 106.472 (23.918) | 109.248 (14.204) | 81.403 (15.151) | 107.671 (11.598) | 94.929 (12.120) | 100.142 (18.166) | |
| Â Â Â Range | 67.966 - 389.709 | 75.595 - 230.491 | 44.453 - 129.331 | 77.415 - 148.214 | 63.818 - 136.295 | 44.453 - 389.709 | |
| kco | < 0.001 | ||||||
| Â Â Â Mean (SD) | 101.483 (12.609) | 109.823 (12.871) | 83.726 (15.200) | 104.169 (11.237) | 94.382 (11.873) | 98.972 (15.443) | |
| Â Â Â Range | 69.265 - 132.372 | 76.242 - 149.720 | 40.972 - 139.418 | 74.349 - 142.603 | 60.955 - 128.938 | 40.972 - 149.720 | |
| FeNO | < 0.001 | ||||||
| Â Â Â Mean (SD) | 65.396 (35.529) | 18.856 (10.255) | 18.481 (11.844) | 18.400 (9.202) | 22.857 (12.578) | 25.509 (22.386) | |
| Â Â Â Range | 12.000 - 226.000 | 5.000 - 62.000 | 3.600 - 100.700 | 3.300 - 54.000 | 4.300 - 68.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.416 (0.259) | 0.221 (0.133) | 0.218 (0.136) | 0.157 (0.096) | 0.184 (0.116) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 2.300 | 0.000 - 0.800 | 0.000 - 0.810 | 0.000 - 0.600 | 0.000 - 0.600 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||||
| Â Â Â Mean (SD) | 3.483 (1.154) | 4.590 (1.406) | 4.664 (1.648) | 3.286 (1.028) | 3.465 (0.979) | 3.856 (1.383) | |
| Â Â Â Range | 1.000 - 8.200 | 1.700 - 10.600 | 1.800 - 12.500 | 1.100 - 6.700 | 1.300 - 7.110 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | ||||||
| Â Â Â Mean (SD) | 1.952 (0.636) | 2.180 (0.600) | 2.134 (0.897) | 1.902 (0.522) | 1.804 (0.682) | 1.983 (0.683) | |
| Â Â Â Range | 0.700 - 5.000 | 1.100 - 4.500 | 0.300 - 9.400 | 0.700 - 4.100 | 0.400 - 11.200 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.421 (0.131) | 0.489 (0.149) | 0.506 (0.201) | 0.363 (0.114) | 0.387 (0.118) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 0.900 | 0.200 - 1.100 | 0.200 - 2.400 | 0.200 - 0.800 | 0.200 - 0.900 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | ||||||
| Â Â Â Mean (SD) | 0.048 (0.051) | 0.046 (0.050) | 0.045 (0.051) | 0.013 (0.032) | 0.020 (0.039) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.300 | 0.000 - 0.100 | 0.000 - 0.100 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||||
| Â Â Â No | 50 (20.7%) | 65 (17.7%) | 159 (45.8%) | 141 (27.5%) | 232 (54.3%) | 647 (34.1%) | |
| Â Â Â Yes | 192 (79.3%) | 302 (82.3%) | 188 (54.2%) | 371 (72.5%) | 195 (45.7%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | ||||||
| Â Â Â No | 122 (50.4%) | 145 (39.5%) | 241 (69.5%) | 194 (37.9%) | 264 (61.8%) | 966 (51.0%) | |
| Â Â Â Yes | 120 (49.6%) | 222 (60.5%) | 106 (30.5%) | 318 (62.1%) | 163 (38.2%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.003 | ||||||
| Â Â Â No | 235 (97.1%) | 342 (93.2%) | 317 (91.4%) | 495 (96.7%) | 398 (93.2%) | 1787 (94.3%) | |
| Â Â Â Yes | 7 (2.9%) | 25 (6.8%) | 30 (8.6%) | 17 (3.3%) | 29 (6.8%) | 108 (5.7%) | |
| nasal_plyposis | < 0.001 | ||||||
| Â Â Â No | 115 (47.5%) | 229 (62.4%) | 180 (51.9%) | 327 (63.9%) | 222 (52.0%) | 1073 (56.6%) | |
| Â Â Â Yes | 127 (52.5%) | 138 (37.6%) | 167 (48.1%) | 185 (36.1%) | 205 (48.0%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | ||||||
| Â Â Â No | 93 (38.4%) | 138 (37.6%) | 82 (23.6%) | 174 (34.0%) | 115 (26.9%) | 602 (31.8%) | |
| Â Â Â Yes | 149 (61.6%) | 229 (62.4%) | 265 (76.4%) | 338 (66.0%) | 312 (73.1%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | ||||||
| Â Â Â onlys saba or non users | 155 (64.0%) | 217 (59.1%) | 210 (60.5%) | 410 (80.1%) | 291 (68.1%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 53 (21.9%) | 86 (23.4%) | 45 (13.0%) | 74 (14.5%) | 79 (18.5%) | 337 (17.8%) | |
| Â Â Â step3 | 15 (6.2%) | 34 (9.3%) | 14 (4.0%) | 16 (3.1%) | 17 (4.0%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 19 (7.9%) | 30 (8.2%) | 78 (22.5%) | 12 (2.3%) | 40 (9.4%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | ||||||
| Â Â Â No | 236 (97.5%) | 360 (98.1%) | 299 (86.2%) | 501 (97.9%) | 408 (95.6%) | 1804 (95.2%) | |
| Â Â Â Yes | 6 (2.5%) | 7 (1.9%) | 48 (13.8%) | 11 (2.1%) | 19 (4.4%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | ||||||
| Â Â Â No | 211 (87.2%) | 307 (83.7%) | 231 (66.6%) | 476 (93.0%) | 364 (85.2%) | 1589 (83.9%) | |
| Â Â Â Yes | 31 (12.8%) | 60 (16.3%) | 116 (33.4%) | 36 (7.0%) | 63 (14.8%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | ||||||
| Â Â Â No | 208 (86.0%) | 313 (85.3%) | 232 (66.9%) | 488 (95.3%) | 347 (81.3%) | 1588 (83.8%) | |
| Â Â Â Yes | 34 (14.0%) | 54 (14.7%) | 115 (33.1%) | 24 (4.7%) | 80 (18.7%) | 307 (16.2%) | |
| gina_control | < 0.001 | ||||||
| Â Â Â controlled | 71 (29.3%) | 125 (34.1%) | 81 (23.3%) | 270 (52.7%) | 170 (39.8%) | 717 (37.8%) | |
| Â Â Â partially controlled | 124 (51.2%) | 176 (48.0%) | 180 (51.9%) | 207 (40.4%) | 205 (48.0%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 47 (19.4%) | 66 (18.0%) | 86 (24.8%) | 35 (6.8%) | 52 (12.2%) | 286 (15.1%) | |
| education | < 0.001 | ||||||
| Â Â Â primary | 143 (59.1%) | 176 (48.0%) | 87 (25.1%) | 296 (57.8%) | 208 (48.7%) | 910 (48.0%) | |
| Â Â Â secondary | 83 (34.3%) | 159 (43.3%) | 132 (38.0%) | 201 (39.3%) | 174 (40.7%) | 749 (39.5%) | |
| Â Â Â tertiary | 16 (6.6%) | 32 (8.7%) | 128 (36.9%) | 15 (2.9%) | 45 (10.5%) | 236 (12.5%) | |
| urbanization_level | 0.033 | ||||||
| Â Â Â No | 120 (49.6%) | 179 (48.8%) | 171 (49.3%) | 266 (52.0%) | 250 (58.5%) | 986 (52.0%) | |
| Â Â Â Yes | 122 (50.4%) | 188 (51.2%) | 176 (50.7%) | 246 (48.0%) | 177 (41.5%) | 909 (48.0%) | |
| smoking_status | < 0.001 | ||||||
| Â Â Â never smoker | 159 (65.7%) | 176 (48.0%) | 88 (25.4%) | 390 (76.2%) | 216 (50.6%) | 1029 (54.3%) | |
| Â Â Â former smokers | 74 (30.6%) | 139 (37.9%) | 182 (52.4%) | 105 (20.5%) | 199 (46.6%) | 699 (36.9%) | |
| Â Â Â current smoker | 9 (3.7%) | 52 (14.2%) | 77 (22.2%) | 17 (3.3%) | 12 (2.8%) | 167 (8.8%) | |
| pack_years | < 0.001 | ||||||
| Â Â Â Mean (SD) | 8.091 (8.764) | 8.186 (7.134) | 31.581 (19.042) | 3.523 (3.827) | 11.500 (8.257) | 11.945 (14.129) | |
| Â Â Â Range | 0.000 - 55.500 | 0.000 - 40.000 | 0.200 - 112.500 | 0.000 - 23.000 | 0.000 - 37.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||||
| Â Â Â No | 94 (38.8%) | 103 (28.1%) | 71 (20.5%) | 290 (56.6%) | 161 (37.7%) | 719 (37.9%) | |
| Â Â Â Yes | 148 (61.2%) | 264 (71.9%) | 276 (79.5%) | 222 (43.4%) | 266 (62.3%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | ||||||
| Â Â Â No | 150 (62.0%) | 235 (64.0%) | 147 (42.4%) | 411 (80.3%) | 206 (48.2%) | 1149 (60.6%) | |
| Â Â Â Yes | 92 (38.0%) | 132 (36.0%) | 200 (57.6%) | 101 (19.7%) | 221 (51.8%) | 746 (39.4%) | |
| household_damage | < 0.001 | ||||||
| Â Â Â No | 215 (88.8%) | 300 (81.7%) | 312 (89.9%) | 441 (86.1%) | 389 (91.1%) | 1657 (87.4%) | |
| Â Â Â Yes | 27 (11.2%) | 67 (18.3%) | 35 (10.1%) | 71 (13.9%) | 38 (8.9%) | 238 (12.6%) | |
| exertion_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 60 (24.8%) | 85 (23.2%) | 139 (40.1%) | 241 (47.1%) | 183 (42.9%) | 708 (37.4%) | |
| Â Â Â Yes | 182 (75.2%) | 282 (76.8%) | 208 (59.9%) | 271 (52.9%) | 244 (57.1%) | 1187 (62.6%) | |
| infection_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 64 (26.4%) | 102 (27.8%) | 139 (40.1%) | 264 (51.6%) | 171 (40.0%) | 740 (39.1%) | |
| Â Â Â Yes | 178 (73.6%) | 265 (72.2%) | 208 (59.9%) | 248 (48.4%) | 256 (60.0%) | 1155 (60.9%) | |
| allergen_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 135 (55.8%) | 216 (58.9%) | 273 (78.7%) | 398 (77.7%) | 319 (74.7%) | 1341 (70.8%) | |
| Â Â Â Yes | 107 (44.2%) | 151 (41.1%) | 74 (21.3%) | 114 (22.3%) | 108 (25.3%) | 554 (29.2%) | |
| irritant_triggered_asthma | 0.004 | ||||||
| Â Â Â No | 200 (82.6%) | 298 (81.2%) | 297 (85.6%) | 460 (89.8%) | 357 (83.6%) | 1612 (85.1%) | |
| Â Â Â Yes | 42 (17.4%) | 69 (18.8%) | 50 (14.4%) | 52 (10.2%) | 70 (16.4%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | ||||||
| Â Â Â No | 152 (62.8%) | 206 (56.1%) | 243 (70.0%) | 386 (75.4%) | 303 (71.0%) | 1290 (68.1%) | |
| Â Â Â Yes | 90 (37.2%) | 161 (43.9%) | 104 (30.0%) | 126 (24.6%) | 124 (29.0%) | 605 (31.9%) | |
| emotion_triggered_asthma | 0.035 | ||||||
| Â Â Â No | 217 (89.7%) | 325 (88.6%) | 316 (91.1%) | 483 (94.3%) | 391 (91.6%) | 1732 (91.4%) | |
| Â Â Â Yes | 25 (10.3%) | 42 (11.4%) | 31 (8.9%) | 29 (5.7%) | 36 (8.4%) | 163 (8.6%) | |
| XCOPD | < 0.001 | ||||||
| Â Â Â No | 226 (93.4%) | 339 (92.4%) | 209 (60.2%) | 503 (98.2%) | 378 (88.5%) | 1655 (87.3%) | |
| Â Â Â Yes | 16 (6.6%) | 28 (7.6%) | 138 (39.8%) | 9 (1.8%) | 49 (11.5%) | 240 (12.7%) |
1.4.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## dyspenea 8.732861e-70 4
## XCOPD 3.100956e-64 4
## smoking_status 1.782637e-61 8
## education 1.766510e-54 8
## Recurrent_wheeze 1.425297e-46 4
## spt_any 3.861261e-36 4
## Chronic_productive_cough 3.371892e-34 4
## smoking_exposure_at_work 1.040319e-33 4
## Breathlessness 4.706881e-30 4
## smoking_exposure_at_home 1.697927e-28 4
## Cough 4.400682e-27 4
## severe_asthma 1.894905e-26 4
## familial_allergy 2.058381e-25 4
## gina_steps 4.934495e-25 12
## Emergency_last_year 5.477466e-23 4
## gina_control 2.898006e-21 8
## Hosptalization_last_year 2.233934e-16 4
## allergen_triggered_asthma 7.054515e-16 4
## exertion_triggered_asthma 1.835146e-15 4
## infection_triggered_asthma 2.629806e-14 4
## Gender 5.765514e-10 4
## weather_triggered_asthma 1.643906e-08 4
## nasal_plyposis 3.056004e-06 4
## Ever_rhinitis 1.911654e-05 4
## household_damage 7.124249e-04 4
## Drug_induced_dyspnea 2.599089e-03 4
## irritant_triggered_asthma 3.890875e-03 4
## urbanization_level 3.336456e-02 4
## emotion_triggered_asthma 3.454272e-02 4
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## Breathlessness=Yes 16.758027 88.429752 67.387863 8.842213e-16
## Gender=No 17.931937 56.611570 40.316623 4.631081e-08
## allergen_triggered_asthma=Yes 19.314079 44.214876 29.234828 1.131134e-07
## spt_any=Yes 15.384615 79.338843 65.857520 1.011934e-06
## exertion_triggered_asthma=Yes 15.332772 75.206612 62.638522 9.711134e-06
## Cough=No 15.115354 78.512397 66.332454 1.002202e-05
## infection_triggered_asthma=Yes 15.411255 73.553719 60.949868 1.157795e-05
## smoking_status=never smoker 15.451895 65.702479 54.300792 1.242373e-04
## dyspenea=No 14.237517 87.190083 78.205805 1.502693e-04
## education=primary 15.714286 59.090909 48.021108 2.282387e-04
## XCOPD=No 13.655589 93.388430 87.335092 1.297110e-03
## nasal_plyposis=Yes 15.450122 52.479339 43.377309 2.368391e-03
## Ever_rhinitis=No 15.448505 38.429752 31.767810 1.876436e-02
## Drug_induced_dyspnea=No 13.150532 97.107438 94.300792 3.396224e-02
## Recurrent_wheeze=Yes 15.738499 26.859504 21.794195 4.502769e-02
## gina_control=uncontrolled 16.433566 19.421488 15.092348 4.976923e-02
## Recurrent_wheeze=No 11.943320 73.140496 78.205805 4.502769e-02
## Drug_induced_dyspnea=Yes 6.481481 2.892562 5.699208 3.396224e-02
## smoking_status=former smokers 10.586552 30.578512 36.886544 2.837052e-02
## Ever_rhinitis=Yes 11.523589 61.570248 68.232190 1.876436e-02
## gina_control=controlled 9.902371 29.338843 37.836412 3.171410e-03
## nasal_plyposis=No 10.717614 47.520661 56.622691 2.368391e-03
## education=tertiary 6.779661 6.611570 12.453826 1.801998e-03
## XCOPD=Yes 6.666667 6.611570 12.664908 1.297110e-03
## smoking_status=current smoker 5.389222 3.719008 8.812665 1.201837e-03
## dyspenea=Yes 7.506053 12.809917 21.794195 1.502693e-04
## infection_triggered_asthma=No 8.648649 26.446281 39.050132 1.157795e-05
## Cough=Yes 8.150470 21.487603 33.667546 1.002202e-05
## exertion_triggered_asthma=No 8.474576 24.793388 37.361478 9.711134e-06
## spt_any=No 7.727975 20.661157 34.142480 1.011934e-06
## allergen_triggered_asthma=No 10.067114 55.785124 70.765172 1.131134e-07
## Gender=Yes 9.283820 43.388430 59.683377 4.631081e-08
## Breathlessness=No 4.530744 11.570248 32.612137 8.842213e-16
## v.test
## Breathlessness=Yes 8.041947
## Gender=No 5.464923
## allergen_triggered_asthma=Yes 5.304288
## spt_any=Yes 4.889304
## exertion_triggered_asthma=Yes 4.423507
## Cough=No 4.416698
## infection_triggered_asthma=Yes 4.385387
## smoking_status=never smoker 3.837611
## dyspenea=No 3.790624
## education=primary 3.685517
## XCOPD=No 3.216618
## nasal_plyposis=Yes 3.039668
## Ever_rhinitis=No 2.350179
## Drug_induced_dyspnea=No 2.120520
## Recurrent_wheeze=Yes 2.004396
## gina_control=uncontrolled 1.961942
## Recurrent_wheeze=No -2.004396
## Drug_induced_dyspnea=Yes -2.120520
## smoking_status=former smokers -2.192125
## Ever_rhinitis=Yes -2.350179
## gina_control=controlled -2.950616
## nasal_plyposis=No -3.039668
## education=tertiary -3.121063
## XCOPD=Yes -3.216618
## smoking_status=current smoker -3.238444
## dyspenea=Yes -3.790624
## infection_triggered_asthma=No -4.385387
## Cough=Yes -4.416698
## exertion_triggered_asthma=No -4.423507
## spt_any=No -4.889304
## allergen_triggered_asthma=No -5.304288
## Gender=Yes -5.464923
## Breathlessness=No -8.041947
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## spt_any=Yes 24.198718 82.288828 65.857520 1.377383e-14
## exertion_triggered_asthma=Yes 23.757372 76.839237 62.638522 1.343916e-10
## allergen_triggered_asthma=Yes 27.256318 41.144414 29.234828 5.050888e-08
## weather_triggered_asthma=Yes 26.611570 43.869210 31.926121 8.587272e-08
## infection_triggered_asthma=Yes 22.943723 72.207084 60.949868 5.788517e-07
## familial_allergy=Yes 23.896663 60.490463 49.023747 9.733047e-07
## Breathlessness=Yes 22.317933 77.656676 67.387863 1.746733e-06
## Gender=Yes 22.723254 70.027248 59.683377 5.319369e-06
## Recurrent_wheeze=Yes 27.360775 30.790191 21.794195 6.685782e-06
## smoking_exposure_at_home=Yes 22.448980 71.934605 62.058047 1.069747e-05
## smoking_status=current smoker 31.137725 14.168937 8.812665 1.377301e-04
## gina_steps=step3 35.416667 9.264305 5.065963 1.527084e-04
## household_damage=Yes 28.151261 18.256131 12.559367 4.314614e-04
## XCOPD=No 20.483384 92.370572 87.335092 7.423836e-04
## Hosptalization_last_year=No 19.955654 98.092643 95.197889 1.824808e-03
## gina_steps=step 1 or 2 25.519288 23.433243 17.783641 2.156189e-03
## dyspenea=Yes 24.697337 27.792916 21.794195 2.424058e-03
## Ever_rhinitis=No 22.923588 37.602180 31.767810 8.203742e-03
## nasal_plyposis=No 21.342032 62.397820 56.622691 1.270064e-02
## irritant_triggered_asthma=Yes 24.381625 18.801090 14.934037 2.362587e-02
## emotion_triggered_asthma=Yes 25.766871 11.444142 8.601583 3.590315e-02
## emotion_triggered_asthma=No 18.764434 88.555858 91.398417 3.590315e-02
## irritant_triggered_asthma=No 18.486352 81.198910 85.065963 2.362587e-02
## education=tertiary 13.559322 8.719346 12.453826 1.316001e-02
## nasal_plyposis=Yes 16.788321 37.602180 43.377309 1.270064e-02
## Ever_rhinitis=Yes 17.710750 62.397820 68.232190 8.203742e-03
## smoking_status=never smoker 17.103984 47.956403 54.300792 6.756332e-03
## dyspenea=No 17.881242 72.207084 78.205805 2.424058e-03
## Hosptalization_last_year=Yes 7.692308 1.907357 4.802111 1.824808e-03
## XCOPD=Yes 11.666667 7.629428 12.664908 7.423836e-04
## household_damage=No 18.105009 81.743869 87.440633 4.314614e-04
## gina_steps=onlys saba or non users 16.913484 59.128065 67.704485 1.166763e-04
## smoking_exposure_at_home=No 14.325452 28.065395 37.941953 1.069747e-05
## Recurrent_wheeze=No 17.139001 69.209809 78.205805 6.685782e-06
## Gender=No 14.397906 29.972752 40.316623 5.319369e-06
## Breathlessness=No 13.268608 22.343324 32.612137 1.746733e-06
## familial_allergy=No 15.010352 39.509537 50.976253 9.733047e-07
## infection_triggered_asthma=No 13.783784 27.792916 39.050132 5.788517e-07
## weather_triggered_asthma=No 15.968992 56.130790 68.073879 8.587272e-08
## allergen_triggered_asthma=No 16.107383 58.855586 70.765172 5.050888e-08
## exertion_triggered_asthma=No 12.005650 23.160763 37.361478 1.343916e-10
## spt_any=No 10.046368 17.711172 34.142480 1.377383e-14
## v.test
## spt_any=Yes 7.698439
## exertion_triggered_asthma=Yes 6.422118
## allergen_triggered_asthma=Yes 5.449510
## weather_triggered_asthma=Yes 5.354333
## infection_triggered_asthma=Yes 4.998143
## familial_allergy=Yes 4.896960
## Breathlessness=Yes 4.780714
## Gender=Yes 4.551781
## Recurrent_wheeze=Yes 4.503454
## smoking_exposure_at_home=Yes 4.402573
## smoking_status=current smoker 3.812209
## gina_steps=step3 3.786623
## household_damage=Yes 3.520053
## XCOPD=No 3.373428
## Hosptalization_last_year=No 3.117356
## gina_steps=step 1 or 2 3.067830
## dyspenea=Yes 3.032663
## Ever_rhinitis=No 2.643567
## nasal_plyposis=No 2.492055
## irritant_triggered_asthma=Yes 2.263159
## emotion_triggered_asthma=Yes 2.098023
## emotion_triggered_asthma=No -2.098023
## irritant_triggered_asthma=No -2.263159
## education=tertiary -2.479410
## nasal_plyposis=Yes -2.492055
## Ever_rhinitis=Yes -2.643567
## smoking_status=never smoker -2.708622
## dyspenea=No -3.032663
## Hosptalization_last_year=Yes -3.117356
## XCOPD=Yes -3.373428
## household_damage=No -3.520053
## gina_steps=onlys saba or non users -3.853006
## smoking_exposure_at_home=No -4.402573
## Recurrent_wheeze=No -4.503454
## Gender=No -4.551781
## Breathlessness=No -4.780714
## familial_allergy=No -4.896960
## infection_triggered_asthma=No -4.998143
## weather_triggered_asthma=No -5.354333
## allergen_triggered_asthma=No -5.449510
## exertion_triggered_asthma=No -6.422118
## spt_any=No -7.698439
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## dyspenea=Yes 46.004843 54.755043 21.794195 2.067100e-52
## XCOPD=Yes 57.500000 39.769452 12.664908 5.769381e-50
## education=tertiary 54.237288 36.887608 12.453826 8.032571e-42
## Chronic_productive_cough=Yes 37.529691 45.533141 22.216359 1.931516e-27
## Recurrent_wheeze=Yes 36.803874 43.804035 21.794195 5.705806e-25
## Cough=Yes 30.877743 56.772334 33.667546 1.013438e-22
## Emergency_last_year=Yes 37.908497 33.429395 16.147757 3.083141e-19
## severe_asthma=Yes 37.459283 33.141210 16.200528 1.518974e-18
## smoking_status=current smoker 46.107784 22.190202 8.812665 3.287349e-18
## gina_steps=step4 or 5 43.575419 22.478386 9.445910 1.250028e-16
## familial_allergy=No 24.948240 69.452450 50.976253 1.438961e-14
## smoking_exposure_at_home=Yes 23.469388 79.538905 62.058047 1.616216e-14
## smoking_exposure_at_work=Yes 26.809651 57.636888 39.366755 2.724467e-14
## Hosptalization_last_year=Yes 52.747253 13.832853 4.802111 2.870552e-14
## smoking_status=former smokers 26.037196 52.449568 36.886544 6.127944e-11
## gina_control=uncontrolled 30.069930 24.783862 15.092348 1.249458e-07
## spt_any=No 24.574961 45.821326 34.142480 6.095069e-07
## Ever_rhinitis=Yes 20.494973 76.368876 68.232190 2.470806e-04
## allergen_triggered_asthma=No 20.357942 78.674352 70.765172 2.548870e-04
## Breathlessness=Yes 20.516836 75.504323 67.387863 2.870039e-04
## Drug_induced_dyspnea=Yes 27.777778 8.645533 5.699208 1.274777e-02
## Gender=Yes 19.893899 64.841499 59.683377 2.971319e-02
## gina_control=partially controlled 20.179372 51.873199 47.071240 4.791763e-02
## nasal_plyposis=Yes 20.316302 48.126801 43.377309 4.909341e-02
## nasal_plyposis=No 16.775396 51.873199 56.622691 4.909341e-02
## Gender=No 15.968586 35.158501 40.316623 2.971319e-02
## Drug_induced_dyspnea=No 17.739228 91.354467 94.300792 1.274777e-02
## gina_steps=step 1 or 2 13.353116 12.968300 17.783641 7.869667e-03
## gina_steps=onlys saba or non users 16.367888 60.518732 67.704485 1.779556e-03
## Breathlessness=No 13.754045 24.495677 32.612137 2.870039e-04
## allergen_triggered_asthma=Yes 13.357401 21.325648 29.234828 2.548870e-04
## Ever_rhinitis=No 13.621262 23.631124 31.767810 2.470806e-04
## spt_any=Yes 15.064103 54.178674 65.857520 6.095069e-07
## gina_control=controlled 11.297071 23.342939 37.836412 2.668544e-10
## Hosptalization_last_year=No 16.574279 86.167147 95.197889 2.870552e-14
## smoking_exposure_at_work=No 12.793734 42.363112 60.633245 2.724467e-14
## smoking_exposure_at_home=No 9.874826 20.461095 37.941953 1.616216e-14
## familial_allergy=Yes 11.410118 30.547550 49.023747 1.438961e-14
## severe_asthma=No 14.609572 66.858790 83.799472 1.518974e-18
## Emergency_last_year=No 14.537445 66.570605 83.852243 3.083141e-19
## education=primary 9.560440 25.072046 48.021108 5.018249e-22
## Cough=No 11.933174 43.227666 66.332454 1.013438e-22
## Recurrent_wheeze=No 13.157895 56.195965 78.205805 5.705806e-25
## Chronic_productive_cough=No 12.822252 54.466859 77.783641 1.931516e-27
## smoking_status=never smoker 8.551992 25.360231 54.300792 1.229335e-33
## XCOPD=No 12.628399 60.230548 87.335092 5.769381e-50
## dyspenea=No 10.593792 45.244957 78.205805 2.067100e-52
## v.test
## dyspenea=Yes 15.235132
## XCOPD=Yes 14.862542
## education=tertiary 13.548992
## Chronic_productive_cough=Yes 10.852921
## Recurrent_wheeze=Yes 10.320277
## Cough=Yes 9.810620
## Emergency_last_year=Yes 8.965701
## severe_asthma=Yes 8.788258
## smoking_status=current smoker 8.701082
## gina_steps=step4 or 5 8.278246
## familial_allergy=No 7.692847
## smoking_exposure_at_home=Yes 7.677976
## smoking_exposure_at_work=Yes 7.610780
## Hosptalization_last_year=Yes 7.604027
## smoking_status=former smokers 6.540583
## gina_control=uncontrolled 5.286109
## spt_any=No 4.988180
## Ever_rhinitis=Yes 3.665267
## allergen_triggered_asthma=No 3.657299
## Breathlessness=Yes 3.626756
## Drug_induced_dyspnea=Yes 2.490739
## Gender=Yes 2.173893
## gina_control=partially controlled 1.978098
## nasal_plyposis=Yes 1.967780
## nasal_plyposis=No -1.967780
## Gender=No -2.173893
## Drug_induced_dyspnea=No -2.490739
## gina_steps=step 1 or 2 -2.657611
## gina_steps=onlys saba or non users -3.124751
## Breathlessness=No -3.626756
## allergen_triggered_asthma=Yes -3.657299
## Ever_rhinitis=No -3.665267
## spt_any=Yes -4.988180
## gina_control=controlled -6.316904
## Hosptalization_last_year=No -7.604027
## smoking_exposure_at_work=No -7.610780
## smoking_exposure_at_home=No -7.677976
## familial_allergy=Yes -7.692847
## severe_asthma=No -8.788258
## Emergency_last_year=No -8.965701
## education=primary -9.647880
## Cough=No -9.810620
## Recurrent_wheeze=No -10.320277
## Chronic_productive_cough=No -10.852921
## smoking_status=never smoker -12.087526
## XCOPD=No -14.862542
## dyspenea=No -15.235132
##
## $`3`
## Cla/Mod Mod/Cla Global p.value
## smoking_status=never smoker 37.900875 76.171875 54.300792 1.602891e-32
## Recurrent_wheeze=No 32.726046 94.726562 78.205805 1.309781e-31
## smoking_exposure_at_work=No 35.770235 80.273438 60.633245 4.379831e-28
## dyspenea=No 32.253711 93.359375 78.205805 3.835837e-26
## smoking_exposure_at_home=No 40.333797 56.640625 37.941953 5.890867e-24
## XCOPD=No 30.392749 98.242188 87.335092 1.410139e-23
## severe_asthma=No 30.730479 95.312500 83.799472 9.737501e-20
## Chronic_productive_cough=No 31.614654 91.015625 77.783641 2.389149e-19
## gina_control=controlled 37.656904 52.734375 37.836412 8.327558e-16
## Breathlessness=No 38.349515 46.289062 32.612137 3.014966e-14
## gina_steps=onlys saba or non users 31.956352 80.078125 67.704485 6.070151e-13
## Emergency_last_year=No 29.955947 92.968750 83.852243 2.588285e-12
## familial_allergy=Yes 34.230355 62.109375 49.023747 3.735882e-12
## infection_triggered_asthma=No 35.675676 51.562500 39.050132 1.648868e-11
## Cough=No 31.662689 77.734375 66.332454 6.628620e-11
## exertion_triggered_asthma=No 34.039548 47.070312 37.361478 1.384659e-07
## education=primary 32.527473 57.812500 48.021108 2.123999e-07
## weather_triggered_asthma=No 29.922481 75.390625 68.073879 2.542462e-05
## allergen_triggered_asthma=No 29.679344 77.734375 70.765172 3.808955e-05
## nasal_plyposis=No 30.475303 63.867188 56.622691 1.016078e-04
## spt_any=Yes 29.727564 72.460938 65.857520 1.971102e-04
## irritant_triggered_asthma=No 28.535980 89.843750 85.065963 2.611174e-04
## Hosptalization_last_year=No 27.771619 97.851562 95.197889 4.767628e-04
## emotion_triggered_asthma=No 27.886836 94.335938 91.398417 4.254751e-03
## Drug_induced_dyspnea=No 27.700056 96.679688 94.300792 4.742272e-03
## gina_steps=step 1 or 2 21.958457 14.453125 17.783641 1.959589e-02
## gina_steps=step3 16.666667 3.125000 5.065963 1.559177e-02
## Drug_induced_dyspnea=Yes 15.740741 3.320312 5.699208 4.742272e-03
## emotion_triggered_asthma=Yes 17.791411 5.664062 8.601583 4.254751e-03
## Hosptalization_last_year=Yes 12.087912 2.148438 4.802111 4.767628e-04
## gina_control=partially controlled 23.206278 40.429688 47.071240 4.176901e-04
## irritant_triggered_asthma=Yes 18.374558 10.156250 14.934037 2.611174e-04
## spt_any=No 21.792890 27.539062 34.142480 1.971102e-04
## nasal_plyposis=Yes 22.506083 36.132812 43.377309 1.016078e-04
## allergen_triggered_asthma=Yes 20.577617 22.265625 29.234828 3.808955e-05
## weather_triggered_asthma=Yes 20.826446 24.609375 31.926121 2.542462e-05
## exertion_triggered_asthma=Yes 22.830666 52.929688 62.638522 1.384659e-07
## smoking_status=current smoker 10.179641 3.320312 8.812665 2.799521e-08
## gina_control=uncontrolled 12.237762 6.835938 15.092348 8.058755e-11
## Cough=Yes 17.868339 22.265625 33.667546 6.628620e-11
## infection_triggered_asthma=Yes 21.471861 48.437500 60.949868 1.648868e-11
## familial_allergy=No 20.082816 37.890625 50.976253 3.735882e-12
## Emergency_last_year=Yes 11.764706 7.031250 16.147757 2.588285e-12
## gina_steps=step4 or 5 6.703911 2.343750 9.445910 7.117360e-13
## Breathlessness=Yes 21.534847 53.710938 67.387863 3.014966e-14
## education=tertiary 6.355932 2.929688 12.453826 1.354623e-17
## Chronic_productive_cough=Yes 10.926366 8.984375 22.216359 2.389149e-19
## severe_asthma=Yes 7.817590 4.687500 16.200528 9.737501e-20
## smoking_status=former smokers 15.021459 20.507812 36.886544 2.190328e-20
## XCOPD=Yes 3.750000 1.757812 12.664908 1.410139e-23
## smoking_exposure_at_home=Yes 18.877551 43.359375 62.058047 5.890867e-24
## dyspenea=Yes 8.232446 6.640625 21.794195 3.835837e-26
## smoking_exposure_at_work=Yes 13.538874 19.726562 39.366755 4.379831e-28
## Recurrent_wheeze=Yes 6.537530 5.273438 21.794195 1.309781e-31
## v.test
## smoking_status=never smoker 11.874658
## Recurrent_wheeze=No 11.697685
## smoking_exposure_at_work=No 10.987692
## dyspenea=No 10.576357
## smoking_exposure_at_home=No 10.093696
## XCOPD=No 10.007685
## severe_asthma=No 9.091842
## Chronic_productive_cough=No 8.993760
## gina_control=controlled 8.049290
## Breathlessness=No 7.597676
## gina_steps=onlys saba or non users 7.198897
## Emergency_last_year=No 6.998440
## familial_allergy=Yes 6.946829
## infection_triggered_asthma=No 6.734154
## Cough=No 6.528828
## exertion_triggered_asthma=No 5.267272
## education=primary 5.188144
## weather_triggered_asthma=No 4.210997
## allergen_triggered_asthma=No 4.118773
## nasal_plyposis=No 3.886720
## spt_any=Yes 3.722692
## irritant_triggered_asthma=No 3.651102
## Hosptalization_last_year=No 3.493483
## emotion_triggered_asthma=No 2.858630
## Drug_induced_dyspnea=No 2.824038
## gina_steps=step 1 or 2 -2.333997
## gina_steps=step3 -2.418334
## Drug_induced_dyspnea=Yes -2.824038
## emotion_triggered_asthma=Yes -2.858630
## Hosptalization_last_year=Yes -3.493483
## gina_control=partially controlled -3.528647
## irritant_triggered_asthma=Yes -3.651102
## spt_any=No -3.722692
## nasal_plyposis=Yes -3.886720
## allergen_triggered_asthma=Yes -4.118773
## weather_triggered_asthma=Yes -4.210997
## exertion_triggered_asthma=Yes -5.267272
## smoking_status=current smoker -5.553533
## gina_control=uncontrolled -6.499500
## Cough=Yes -6.528828
## infection_triggered_asthma=Yes -6.734154
## familial_allergy=No -6.946829
## Emergency_last_year=Yes -6.998440
## gina_steps=step4 or 5 -7.177161
## Breathlessness=Yes -7.597676
## education=tertiary -8.538937
## Chronic_productive_cough=Yes -8.993760
## severe_asthma=Yes -9.091842
## smoking_status=former smokers -9.252631
## XCOPD=Yes -10.007685
## smoking_exposure_at_home=Yes -10.093696
## dyspenea=Yes -10.576357
## smoking_exposure_at_work=Yes -10.987692
## Recurrent_wheeze=Yes -11.697685
##
## $`4`
## Cla/Mod Mod/Cla Global p.value
## spt_any=No 35.857805 54.332553 34.142480 1.295020e-22
## smoking_exposure_at_work=Yes 29.624665 51.756440 39.366755 3.727245e-09
## Breathlessness=No 30.097087 43.559719 32.612137 7.020424e-08
## dyspenea=No 25.033738 86.885246 78.205805 2.881585e-07
## Recurrent_wheeze=No 25.033738 86.885246 78.205805 2.881585e-07
## familial_allergy=No 27.329193 61.826698 50.976253 3.244780e-07
## smoking_status=former smokers 28.469242 46.604215 36.886544 2.913072e-06
## urbanization_level=No 25.354970 58.548009 52.031662 2.182408e-03
## household_damage=No 23.476162 91.100703 87.440633 7.809943e-03
## exertion_triggered_asthma=No 25.847458 42.857143 37.361478 8.068208e-03
## Ever_rhinitis=Yes 24.129930 73.067916 68.232190 1.404658e-02
## nasal_plyposis=Yes 24.939173 48.009368 43.377309 2.874837e-02
## allergen_triggered_asthma=No 23.788218 74.707260 70.765172 4.067127e-02
## allergen_triggered_asthma=Yes 19.494585 25.292740 29.234828 4.067127e-02
## nasal_plyposis=No 20.689655 51.990632 56.622691 2.874837e-02
## Ever_rhinitis=No 19.102990 26.932084 31.767810 1.404658e-02
## exertion_triggered_asthma=Yes 20.556024 57.142857 62.638522 8.068208e-03
## household_damage=Yes 15.966387 8.899297 12.559367 7.809943e-03
## urbanization_level=Yes 19.471947 41.451991 47.968338 2.182408e-03
## familial_allergy=Yes 17.545748 38.173302 49.023747 3.244780e-07
## dyspenea=Yes 13.559322 13.114754 21.794195 2.881585e-07
## Recurrent_wheeze=Yes 13.559322 13.114754 21.794195 2.881585e-07
## Breathlessness=Yes 18.872357 56.440281 67.387863 7.020424e-08
## smoking_status=current smoker 7.185629 2.810304 8.812665 4.141056e-08
## smoking_exposure_at_work=No 17.928634 48.243560 60.633245 3.727245e-09
## spt_any=Yes 15.625000 45.667447 65.857520 1.295020e-22
## v.test
## spt_any=No 9.785850
## smoking_exposure_at_work=Yes 5.895865
## Breathlessness=No 5.390648
## dyspenea=No 5.131032
## Recurrent_wheeze=No 5.131032
## familial_allergy=No 5.108645
## smoking_status=former smokers 4.676856
## urbanization_level=No 3.064217
## household_damage=No 2.660178
## exertion_triggered_asthma=No 2.649202
## Ever_rhinitis=Yes 2.456070
## nasal_plyposis=Yes 2.186920
## allergen_triggered_asthma=No 2.046866
## allergen_triggered_asthma=Yes -2.046866
## nasal_plyposis=No -2.186920
## Ever_rhinitis=No -2.456070
## exertion_triggered_asthma=Yes -2.649202
## household_damage=Yes -2.660178
## urbanization_level=Yes -3.064217
## familial_allergy=Yes -5.108645
## dyspenea=Yes -5.131032
## Recurrent_wheeze=Yes -5.131032
## Breathlessness=Yes -5.390648
## smoking_status=current smoker -5.484728
## smoking_exposure_at_work=No -5.895865
## spt_any=Yes -9.785850
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.52963420 1.419208e-307
## pack_years 0.47335370 3.069546e-261
## FeNO 0.47122826 1.374417e-259
## kco 0.32814842 1.845899e-161
## tlco 0.32414291 5.016985e-159
## BMI 0.25992799 7.177280e-122
## FEV1_FVC_ratio_post 0.24730249 5.982284e-115
## onset_age_asthma 0.23893225 1.998308e-110
## Eosinophiles 0.23227331 7.305952e-107
## Neutrophiles 0.19039174 3.778311e-85
## Reversibility 0.15369277 4.776113e-67
## Monocytes 0.14079031 7.095291e-61
## Basophiles 0.10535347 2.056224e-44
## pd20 0.08732285 2.639520e-36
## Lymphocytes 0.04462741 7.915666e-18
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## FeNO 29.677249 6.539628e+01 2.550929e+01 3.545507e+01
## Eosinophiles 19.891147 4.164463e-01 2.196359e-01 2.579892e-01
## Reversibility 14.449652 1.399315e+01 7.333086e+00 1.175772e+01
## Basophiles 6.076161 4.822314e-02 3.133509e-02 5.135905e-02
## tlco 5.804100 1.064724e+02 1.001420e+02 2.386841e+01
## kco 2.708011 1.014832e+02 9.897243e+01 1.258268e+01
## pd20 -4.007428 1.385852e+03 1.952471e+03 1.647009e+03
## FEV1_FVC_ratio_post -4.208761 7.456837e-01 7.699727e-01 1.028191e-01
## Neutrophiles -4.495590 3.482851e+00 3.856132e+00 1.152106e+00
## pack_years -4.543152 8.090618e+00 1.194451e+01 8.745548e+00
## BMI -5.308587 2.550626e+01 2.706171e+01 3.562335e+00
## Overall sd p.value
## FeNO 2.238045e+01 1.509912e-193
## Eosinophiles 1.647591e-01 4.855186e-88
## Reversibility 7.675073e+00 2.519561e-47
## Basophiles 4.628193e-02 1.230941e-09
## tlco 1.816168e+01 6.471266e-09
## kco 1.543910e+01 6.768785e-03
## pd20 2.354436e+03 6.138369e-05
## FEV1_FVC_ratio_post 9.609862e-02 2.567750e-05
## Neutrophiles 1.382643e+00 6.937730e-06
## pack_years 1.412548e+01 5.541925e-06
## BMI 4.879071e+00 1.104786e-07
##
## $`1`
## v.test Mean in category Overall mean sd in category
## BMI 18.194966 31.22394479 2.706171e+01 5.328388e+00
## kco 14.989717 109.82303876 9.897243e+01 1.285393e+01
## Neutrophiles 11.322277 4.59010899 3.856132e+00 1.404461e+00
## tlco 10.693746 109.24790718 1.001420e+02 1.418513e+01
## Monocytes 8.707375 0.48937330 4.264011e-01 1.487327e-01
## FEV1_FVC_ratio_post 7.731372 0.80480741 7.699727e-01 7.486366e-02
## Basophiles 6.567306 0.04558583 3.133509e-02 5.019985e-02
## Lymphocytes 6.172153 2.18046322 1.982802e+00 5.987558e-01
## Reversibility -3.150785 6.19927700 7.333086e+00 5.584120e+00
## pack_years -5.675808 8.18553134 1.194451e+01 7.124678e+00
## FeNO -6.340192 18.85640327 2.550929e+01 1.024149e+01
## onset_age_asthma -7.135435 15.77929155 2.149024e+01 1.174306e+01
## Age -8.524001 43.43869210 4.971821e+01 1.139893e+01
## pd20 -8.820681 978.76518851 1.952471e+03 1.212536e+03
## Overall sd p.value
## BMI 4.879071e+00 5.657440e-74
## kco 1.543910e+01 8.571808e-51
## Neutrophiles 1.382643e+00 1.017933e-29
## tlco 1.816168e+01 1.088826e-26
## Monocytes 1.542493e-01 3.109933e-18
## FEV1_FVC_ratio_post 9.609862e-02 1.063935e-14
## Basophiles 4.628193e-02 5.123364e-11
## Lymphocytes 6.830395e-01 6.736608e-10
## Reversibility 7.675073e+00 1.628324e-03
## pack_years 1.412548e+01 1.380359e-08
## FeNO 2.238045e+01 2.294788e-10
## onset_age_asthma 1.707061e+01 9.648148e-13
## Age 1.571245e+01 1.541339e-17
## pd20 2.354436e+03 1.137655e-18
##
## $`2`
## v.test Mean in category Overall mean sd in category
## pack_years 28.643969 31.5811527 1.194451e+01 1.901471e+01
## Age 20.179923 65.1066282 4.971821e+01 9.259788e+00
## onset_age_asthma 14.703189 33.6714697 2.149024e+01 1.962094e+01
## Neutrophiles 12.032899 4.6635735 3.856132e+00 1.645269e+00
## Monocytes 10.589823 0.5056772 4.264011e-01 2.005016e-01
## BMI 6.875723 28.6898248 2.706171e+01 5.001402e+00
## Basophiles 6.013089 0.0448415 3.133509e-02 5.141419e-02
## pd20 6.008991 2639.0954304 1.952471e+03 1.755471e+03
## Reversibility 5.941960 9.5463999 7.333086e+00 8.854367e+00
## Lymphocytes 4.566485 2.1341787 1.982802e+00 8.953109e-01
## FeNO -6.470565 18.4811239 2.550929e+01 1.182667e+01
## FEV1_FVC_ratio_post -17.411925 0.6887655 7.699727e-01 1.157950e-01
## kco -20.348350 83.7255171 9.897243e+01 1.517849e+01
## tlco -21.260023 81.4027935 1.001420e+02 1.512867e+01
## Overall sd p.value
## pack_years 1.412548e+01 1.905786e-180
## Age 1.571245e+01 1.469756e-90
## onset_age_asthma 1.707061e+01 6.149412e-49
## Neutrophiles 1.382643e+00 2.386311e-33
## Monocytes 1.542493e-01 3.322199e-26
## BMI 4.879071e+00 6.167622e-12
## Basophiles 4.628193e-02 1.820216e-09
## pd20 2.354436e+03 1.866819e-09
## Reversibility 7.675073e+00 2.816347e-09
## Lymphocytes 6.830395e-01 4.959704e-06
## FeNO 2.238045e+01 9.763703e-11
## FEV1_FVC_ratio_post 9.609862e-02 6.699298e-68
## kco 1.543910e+01 4.801657e-92
## tlco 1.816168e+01 2.662836e-100
##
## $`3`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 14.328025 8.219710e-01 7.699727e-01 5.511100e-02
## tlco 10.977173 1.076709e+02 1.001420e+02 1.158701e+01
## kco 8.913361 1.041694e+02 9.897243e+01 1.122622e+01
## pd20 -2.316485 1.746502e+03 1.952471e+03 3.121557e+03
## Lymphocytes -3.133558 1.901973e+00 1.982802e+00 5.215596e-01
## FeNO -8.411338 1.840010e+01 2.550929e+01 9.192728e+00
## Reversibility -8.449259 4.884095e+00 7.333086e+00 4.058468e+00
## Eosinophiles -10.140165 1.565430e-01 2.196359e-01 9.597140e-02
## Basophiles -10.396376 1.316406e-02 3.133509e-02 3.161889e-02
## Monocytes -10.802154 3.634766e-01 4.264011e-01 1.138445e-01
## Neutrophiles -10.927585 3.285547e+00 3.856132e+00 1.027281e+00
## BMI -14.276858 2.443110e+01 2.706171e+01 3.317560e+00
## onset_age_asthma -14.657537 1.204102e+01 2.149024e+01 8.332230e+00
## pack_years -15.787026 3.523002e+00 1.194451e+01 3.822798e+00
## Age -23.760761 3.561914e+01 4.971821e+01 9.912186e+00
## Overall sd p.value
## FEV1_FVC_ratio_post 9.609862e-02 1.462194e-46
## tlco 1.816168e+01 4.920830e-28
## kco 1.543910e+01 4.950846e-19
## pd20 2.354436e+03 2.053180e-02
## Lymphocytes 6.830395e-01 1.727010e-03
## FeNO 2.238045e+01 4.053589e-17
## Reversibility 7.675073e+00 2.931584e-17
## Eosinophiles 1.647591e-01 3.664805e-24
## Basophiles 4.628193e-02 2.575435e-25
## Monocytes 1.542493e-01 3.362235e-27
## Neutrophiles 1.382643e+00 8.508244e-28
## BMI 4.879071e+00 3.050465e-46
## onset_age_asthma 1.707061e+01 1.205681e-48
## pack_years 1.412548e+01 3.821799e-56
## Age 1.571245e+01 8.505048e-125
##
## $`4`
## v.test Mean in category Overall mean sd in category
## Age 15.964329 6.040515e+01 4.971821e+01 9.929365e+00
## onset_age_asthma 9.913501 2.870023e+01 2.149024e+01 1.765978e+01
## pd20 8.443801 2.799472e+03 1.952471e+03 2.337466e+03
## FeNO -2.781191 2.285738e+01 2.550929e+01 1.256297e+01
## FEV1_FVC_ratio_post -3.060570 7.574419e-01 7.699727e-01 7.417503e-02
## BMI -4.159588 2.619704e+01 2.706171e+01 3.614839e+00
## Eosinophiles -5.039304 1.842623e-01 2.196359e-01 1.159953e-01
## Reversibility -5.083291 5.670873e+00 7.333086e+00 5.712651e+00
## Basophiles -5.582224 2.032787e-02 3.133509e-02 3.868912e-02
## Monocytes -6.055726 3.866042e-01 4.264011e-01 1.176843e-01
## Lymphocytes -6.129587 1.804426e+00 1.982802e+00 6.810739e-01
## Neutrophiles -6.642370 3.464848e+00 3.856132e+00 9.777421e-01
## tlco -6.737672 9.492852e+01 1.001420e+02 1.210566e+01
## kco -6.978086 9.438238e+01 9.897243e+01 1.185941e+01
## Overall sd p.value
## Age 1.571245e+01 2.264623e-57
## onset_age_asthma 1.707061e+01 3.636760e-23
## pd20 2.354436e+03 3.071821e-17
## FeNO 2.238045e+01 5.415980e-03
## FEV1_FVC_ratio_post 9.609862e-02 2.209161e-03
## BMI 4.879071e+00 3.188218e-05
## Eosinophiles 1.647591e-01 4.672277e-07
## Reversibility 7.675073e+00 3.709509e-07
## Basophiles 4.628193e-02 2.374629e-08
## Monocytes 1.542493e-01 1.397856e-09
## Lymphocytes 6.830395e-01 8.810774e-10
## Neutrophiles 1.382643e+00 3.086781e-11
## tlco 1.816168e+01 1.609444e-11
## kco 1.543910e+01 2.992295e-121.4.3 Radar Plots
1.4.4 parallel box plots
1.4.5 parallel coordinate plot
1.5 Deep Empedding Clustering on the encoded data 4 clusters
1.5.1 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=458) | 1 (N=545) | 2 (N=358) | 3 (N=534) | Total (N=1895) | p value | |
|---|---|---|---|---|---|---|
| Age | < 0.001 | |||||
| Â Â Â Mean (SD) | 65.753 (9.281) | 44.690 (12.294) | 48.760 (14.631) | 41.740 (13.967) | 49.718 (15.717) | |
| Â Â Â Range | 28.000 - 86.000 | 18.000 - 78.000 | 18.000 - 82.000 | 17.000 - 97.000 | 17.000 - 97.000 | |
| Gender | < 0.001 | |||||
| Â Â Â No | 168 (36.7%) | 158 (29.0%) | 191 (53.4%) | 247 (46.3%) | 764 (40.3%) | |
| Â Â Â Yes | 290 (63.3%) | 387 (71.0%) | 167 (46.6%) | 287 (53.7%) | 1131 (59.7%) | |
| BMI | < 0.001 | |||||
| Â Â Â Mean (SD) | 28.548 (4.965) | 27.515 (5.161) | 26.435 (4.347) | 25.744 (4.421) | 27.062 (4.880) | |
| Â Â Â Range | 17.603 - 48.870 | 17.509 - 50.058 | 18.084 - 42.453 | 17.029 - 46.094 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | |||||
| Â Â Â Mean (SD) | 35.105 (19.370) | 17.761 (12.524) | 21.494 (17.386) | 13.616 (10.780) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 72.000 | 1.000 - 62.000 | 1.000 - 70.000 | -1.000 - 58.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | |||||
| Â Â Â No | 223 (48.7%) | 341 (62.6%) | 256 (71.5%) | 437 (81.8%) | 1257 (66.3%) | |
| Â Â Â Yes | 235 (51.3%) | 204 (37.4%) | 102 (28.5%) | 97 (18.2%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | |||||
| Â Â Â No | 130 (28.4%) | 130 (23.9%) | 43 (12.0%) | 315 (59.0%) | 618 (32.6%) | |
| Â Â Â Yes | 328 (71.6%) | 415 (76.1%) | 315 (88.0%) | 219 (41.0%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | |||||
| Â Â Â No | 299 (65.3%) | 439 (80.6%) | 255 (71.2%) | 489 (91.6%) | 1482 (78.2%) | |
| Â Â Â Yes | 159 (34.7%) | 106 (19.4%) | 103 (28.8%) | 45 (8.4%) | 413 (21.8%) | |
| dyspenea | < 0.001 | |||||
| Â Â Â No | 253 (55.2%) | 436 (80.0%) | 306 (85.5%) | 487 (91.2%) | 1482 (78.2%) | |
| Â Â Â Yes | 205 (44.8%) | 109 (20.0%) | 52 (14.5%) | 47 (8.8%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | |||||
| Â Â Â No | 278 (60.7%) | 423 (77.6%) | 291 (81.3%) | 482 (90.3%) | 1474 (77.8%) | |
| Â Â Â Yes | 180 (39.3%) | 122 (22.4%) | 67 (18.7%) | 52 (9.7%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.703 (0.112) | 0.796 (0.066) | 0.755 (0.102) | 0.810 (0.065) | 0.770 (0.096) | |
| Â Â Â Range | 0.230 - 0.994 | 0.541 - 1.028 | 0.424 - 1.590 | 0.557 - 1.009 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | |||||
| Â Â Â Mean (SD) | 8.627 (8.493) | 5.829 (5.399) | 12.099 (10.536) | 4.563 (4.097) | 7.333 (7.677) | |
| Â Â Â Range | -6.858 - 55.102 | -26.774 - 30.890 | -12.121 - 77.242 | -12.603 - 26.316 | -26.774 - 77.242 | |
| pd20 | < 0.001 | |||||
| Â Â Â Mean (SD) | 2987.810 (1994.137) | 1812.680 (2567.594) | 1432.356 (1615.766) | 1555.846 (2557.623) | 1952.471 (2355.058) | |
| Â Â Â Range | -1417.620 - 13923.750 | -1417.620 - 38775.000 | -3701.250 - 9693.750 | -26261.250 - 19387.500 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | |||||
| Â Â Â Mean (SD) | 82.807 (14.553) | 106.508 (17.813) | 105.515 (14.274) | 104.910 (13.746) | 100.142 (18.166) | |
| Â Â Â Range | 44.453 - 136.837 | 67.252 - 389.709 | 67.966 - 161.534 | 63.818 - 230.491 | 44.453 - 389.709 | |
| kco | < 0.001 | |||||
| Â Â Â Mean (SD) | 85.049 (14.299) | 105.528 (12.856) | 103.274 (13.624) | 101.340 (12.271) | 98.972 (15.443) | |
| Â Â Â Range | 40.972 - 127.030 | 67.106 - 144.168 | 60.955 - 149.720 | 69.265 - 142.603 | 40.972 - 149.720 | |
| FeNO | < 0.001 | |||||
| Â Â Â Mean (SD) | 19.006 (11.585) | 18.535 (12.325) | 54.705 (32.710) | 18.632 (9.383) | 25.509 (22.386) | |
| Â Â Â Range | 3.600 - 100.700 | 5.000 - 226.000 | 5.000 - 203.000 | 3.300 - 64.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.210 (0.131) | 0.169 (0.094) | 0.392 (0.233) | 0.164 (0.103) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 0.810 | 0.000 - 0.600 | 0.050 - 2.300 | 0.000 - 0.700 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 4.478 (1.628) | 3.842 (1.307) | 3.672 (1.228) | 3.461 (1.122) | 3.856 (1.383) | |
| Â Â Â Range | 1.300 - 12.500 | 1.100 - 10.600 | 1.000 - 8.950 | 1.300 - 7.600 | 1.000 - 12.500 | |
| Lymphocyties | 0.009 | |||||
| Â Â Â Mean (SD) | 2.069 (0.946) | 1.952 (0.548) | 1.997 (0.645) | 1.931 (0.544) | 1.983 (0.683) | |
| Â Â Â Range | 0.300 - 11.200 | 0.600 - 4.100 | 0.600 - 5.000 | 0.800 - 4.100 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.482 (0.193) | 0.403 (0.125) | 0.444 (0.149) | 0.390 (0.131) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 2.400 | 0.200 - 1.100 | 0.200 - 1.000 | 0.200 - 1.000 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | |||||
| Â Â Â Mean (SD) | 0.039 (0.050) | 0.022 (0.040) | 0.054 (0.051) | 0.020 (0.038) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.300 | 0.000 - 0.200 | 0.000 - 0.200 | 0.000 - 0.190 | 0.000 - 0.300 | |
| spt_any | < 0.001 | |||||
| Â Â Â No | 278 (60.7%) | 176 (32.3%) | 81 (22.6%) | 112 (21.0%) | 647 (34.1%) | |
| Â Â Â Yes | 180 (39.3%) | 369 (67.7%) | 277 (77.4%) | 422 (79.0%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | |||||
| Â Â Â No | 335 (73.1%) | 219 (40.2%) | 170 (47.5%) | 242 (45.3%) | 966 (51.0%) | |
| Â Â Â Yes | 123 (26.9%) | 326 (59.8%) | 188 (52.5%) | 292 (54.7%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.017 | |||||
| Â Â Â No | 420 (91.7%) | 512 (93.9%) | 345 (96.4%) | 510 (95.5%) | 1787 (94.3%) | |
| Â Â Â Yes | 38 (8.3%) | 33 (6.1%) | 13 (3.6%) | 24 (4.5%) | 108 (5.7%) | |
| nasal_plyposis | 0.001 | |||||
| Â Â Â No | 238 (52.0%) | 333 (61.1%) | 182 (50.8%) | 320 (59.9%) | 1073 (56.6%) | |
| Â Â Â Yes | 220 (48.0%) | 212 (38.9%) | 176 (49.2%) | 214 (40.1%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | |||||
| Â Â Â No | 93 (20.3%) | 159 (29.2%) | 118 (33.0%) | 232 (43.4%) | 602 (31.8%) | |
| Â Â Â Yes | 365 (79.7%) | 386 (70.8%) | 240 (67.0%) | 302 (56.6%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | |||||
| Â Â Â onlys saba or non users | 299 (65.3%) | 315 (57.8%) | 214 (59.8%) | 455 (85.2%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 69 (15.1%) | 130 (23.9%) | 83 (23.2%) | 55 (10.3%) | 337 (17.8%) | |
| Â Â Â step3 | 17 (3.7%) | 39 (7.2%) | 22 (6.1%) | 18 (3.4%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 73 (15.9%) | 61 (11.2%) | 39 (10.9%) | 6 (1.1%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | |||||
| Â Â Â No | 402 (87.8%) | 530 (97.2%) | 348 (97.2%) | 524 (98.1%) | 1804 (95.2%) | |
| Â Â Â Yes | 56 (12.2%) | 15 (2.8%) | 10 (2.8%) | 10 (1.9%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | |||||
| Â Â Â No | 328 (71.6%) | 464 (85.1%) | 312 (87.2%) | 485 (90.8%) | 1589 (83.9%) | |
| Â Â Â Yes | 130 (28.4%) | 81 (14.9%) | 46 (12.8%) | 49 (9.2%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | |||||
| Â Â Â No | 335 (73.1%) | 449 (82.4%) | 290 (81.0%) | 514 (96.3%) | 1588 (83.8%) | |
| Â Â Â Yes | 123 (26.9%) | 96 (17.6%) | 68 (19.0%) | 20 (3.7%) | 307 (16.2%) | |
| gina_control | < 0.001 | |||||
| Â Â Â controlled | 120 (26.2%) | 178 (32.7%) | 113 (31.6%) | 306 (57.3%) | 717 (37.8%) | |
| Â Â Â partially controlled | 236 (51.5%) | 292 (53.6%) | 181 (50.6%) | 183 (34.3%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 102 (22.3%) | 75 (13.8%) | 64 (17.9%) | 45 (8.4%) | 286 (15.1%) | |
| education | < 0.001 | |||||
| Â Â Â primary | 153 (33.4%) | 307 (56.3%) | 186 (52.0%) | 264 (49.4%) | 910 (48.0%) | |
| Â Â Â secondary | 163 (35.6%) | 215 (39.4%) | 138 (38.5%) | 233 (43.6%) | 749 (39.5%) | |
| Â Â Â tertiary | 142 (31.0%) | 23 (4.2%) | 34 (9.5%) | 37 (6.9%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | |||||
| Â Â Â No | 280 (61.1%) | 312 (57.2%) | 196 (54.7%) | 198 (37.1%) | 986 (52.0%) | |
| Â Â Â Yes | 178 (38.9%) | 233 (42.8%) | 162 (45.3%) | 336 (62.9%) | 909 (48.0%) | |
| smoking_status | < 0.001 | |||||
| Â Â Â never smoker | 151 (33.0%) | 342 (62.8%) | 212 (59.2%) | 324 (60.7%) | 1029 (54.3%) | |
| Â Â Â former smokers | 230 (50.2%) | 174 (31.9%) | 122 (34.1%) | 173 (32.4%) | 699 (36.9%) | |
| Â Â Â current smoker | 77 (16.8%) | 29 (5.3%) | 24 (6.7%) | 37 (6.9%) | 167 (8.8%) | |
| pack_years | < 0.001 | |||||
| Â Â Â Mean (SD) | 27.069 (18.779) | 7.011 (6.790) | 8.306 (8.357) | 6.447 (7.250) | 11.945 (14.129) | |
| Â Â Â Range | 0.100 - 112.500 | 0.000 - 36.000 | 0.000 - 55.500 | 0.000 - 43.500 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | |||||
| Â Â Â No | 112 (24.5%) | 221 (40.6%) | 129 (36.0%) | 257 (48.1%) | 719 (37.9%) | |
| Â Â Â Yes | 346 (75.5%) | 324 (59.4%) | 229 (64.0%) | 277 (51.9%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | |||||
| Â Â Â No | 191 (41.7%) | 365 (67.0%) | 218 (60.9%) | 375 (70.2%) | 1149 (60.6%) | |
| Â Â Â Yes | 267 (58.3%) | 180 (33.0%) | 140 (39.1%) | 159 (29.8%) | 746 (39.4%) | |
| household_damage | 0.034 | |||||
| Â Â Â No | 413 (90.2%) | 460 (84.4%) | 319 (89.1%) | 465 (87.1%) | 1657 (87.4%) | |
| Â Â Â Yes | 45 (9.8%) | 85 (15.6%) | 39 (10.9%) | 69 (12.9%) | 238 (12.6%) | |
| exertion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 176 (38.4%) | 32 (5.9%) | 76 (21.2%) | 424 (79.4%) | 708 (37.4%) | |
| Â Â Â Yes | 282 (61.6%) | 513 (94.1%) | 282 (78.8%) | 110 (20.6%) | 1187 (62.6%) | |
| infection_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 164 (35.8%) | 33 (6.1%) | 85 (23.7%) | 458 (85.8%) | 740 (39.1%) | |
| Â Â Â Yes | 294 (64.2%) | 512 (93.9%) | 273 (76.3%) | 76 (14.2%) | 1155 (60.9%) | |
| allergen_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 353 (77.1%) | 302 (55.4%) | 210 (58.7%) | 476 (89.1%) | 1341 (70.8%) | |
| Â Â Â Yes | 105 (22.9%) | 243 (44.6%) | 148 (41.3%) | 58 (10.9%) | 554 (29.2%) | |
| irritant_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 399 (87.1%) | 402 (73.8%) | 291 (81.3%) | 520 (97.4%) | 1612 (85.1%) | |
| Â Â Â Yes | 59 (12.9%) | 143 (26.2%) | 67 (18.7%) | 14 (2.6%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 331 (72.3%) | 230 (42.2%) | 212 (59.2%) | 517 (96.8%) | 1290 (68.1%) | |
| Â Â Â Yes | 127 (27.7%) | 315 (57.8%) | 146 (40.8%) | 17 (3.2%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | |||||
| Â Â Â No | 422 (92.1%) | 471 (86.4%) | 308 (86.0%) | 531 (99.4%) | 1732 (91.4%) | |
| Â Â Â Yes | 36 (7.9%) | 74 (13.6%) | 50 (14.0%) | 3 (0.6%) | 163 (8.6%) | |
| XCOPD | < 0.001 | |||||
| Â Â Â No | 304 (66.4%) | 502 (92.1%) | 332 (92.7%) | 517 (96.8%) | 1655 (87.3%) | |
| Â Â Â Yes | 154 (33.6%) | 43 (7.9%) | 26 (7.3%) | 17 (3.2%) | 240 (12.7%) |
1.5.2 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## infection_triggered_asthma 6.189615e-168 3
## exertion_triggered_asthma 8.155742e-146 3
## weather_triggered_asthma 1.145254e-83 3
## Breathlessness 2.819104e-56 3
## XCOPD 4.836311e-53 3
## spt_any 1.447700e-44 3
## dyspenea 1.474948e-44 3
## education 1.237040e-41 6
## allergen_triggered_asthma 1.626466e-39 3
## Cough 8.656088e-28 3
## Chronic_productive_cough 1.437910e-27 3
## gina_control 3.152960e-27 6
## irritant_triggered_asthma 1.014061e-26 3
## familial_allergy 1.035399e-26 3
## gina_steps 1.522914e-26 9
## smoking_status 1.267340e-24 6
## Recurrent_wheeze 2.696980e-24 3
## severe_asthma 5.269831e-22 3
## smoking_exposure_at_work 3.222878e-21 3
## emotion_triggered_asthma 4.639049e-16 3
## Hosptalization_last_year 7.877491e-16 3
## Emergency_last_year 8.147680e-16 3
## urbanization_level 4.171803e-15 3
## Gender 5.887327e-14 3
## Ever_rhinitis 1.168482e-13 3
## smoking_exposure_at_home 3.520046e-13 3
## nasal_plyposis 1.279767e-03 3
## Drug_induced_dyspnea 1.717488e-02 3
## household_damage 3.413098e-02 3
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=Yes 64.16667 33.624454 12.664908 3.896970e-46
## spt_any=No 42.96754 60.698690 34.142480 2.167292e-41
## dyspenea=Yes 49.63680 44.759825 21.794195 1.685373e-38
## education=tertiary 60.16949 31.004367 12.453826 3.340855e-37
## familial_allergy=No 34.67909 73.144105 50.976253 2.065134e-28
## Chronic_productive_cough=Yes 42.75534 39.301310 22.216359 3.962157e-22
## smoking_exposure_at_work=Yes 35.79088 58.296943 39.366755 4.289293e-21
## Cough=Yes 36.83386 51.310044 33.667546 2.363067e-19
## Emergency_last_year=Yes 42.48366 28.384279 16.147757 7.898957e-15
## Hosptalization_last_year=Yes 61.53846 12.227074 4.802111 8.396945e-15
## Recurrent_wheeze=Yes 38.49879 34.716157 21.794195 1.236431e-13
## smoking_exposure_at_home=Yes 29.42177 75.545852 62.058047 3.098246e-12
## severe_asthma=Yes 40.06515 26.855895 16.200528 1.129165e-11
## smoking_status=former smokers 32.90415 50.218341 36.886544 2.015137e-11
## smoking_status=current smoker 46.10778 16.812227 8.812665 8.407061e-11
## Ever_rhinitis=Yes 28.22892 79.694323 68.232190 5.227330e-10
## gina_steps=step4 or 5 40.78212 15.938865 9.445910 2.326426e-07
## gina_control=uncontrolled 35.66434 22.270742 15.092348 2.018706e-06
## urbanization_level=No 28.39757 61.135371 52.031662 7.173104e-06
## allergen_triggered_asthma=No 26.32364 77.074236 70.765172 5.500810e-04
## Drug_induced_dyspnea=Yes 35.18519 8.296943 5.699208 8.148283e-03
## nasal_plyposis=Yes 26.76399 48.034934 43.377309 2.133010e-02
## Breathlessness=Yes 25.68520 71.615721 67.387863 2.590791e-02
## weather_triggered_asthma=No 25.65891 72.270742 68.073879 2.613725e-02
## gina_control=partially controlled 26.45740 51.528384 47.071240 2.850836e-02
## household_damage=No 24.92456 90.174672 87.440633 3.964645e-02
## education=secondary 21.76235 35.589520 39.525066 4.750227e-02
## household_damage=Yes 18.90756 9.825328 12.559367 3.964645e-02
## weather_triggered_asthma=Yes 20.99174 27.729258 31.926121 2.613725e-02
## Breathlessness=No 21.03560 28.384279 32.612137 2.590791e-02
## nasal_plyposis=No 22.18080 51.965066 56.622691 2.133010e-02
## Drug_induced_dyspnea=No 23.50308 91.703057 94.300792 8.148283e-03
## allergen_triggered_asthma=Yes 18.95307 22.925764 29.234828 5.500810e-04
## urbanization_level=Yes 19.58196 38.864629 47.968338 7.173104e-06
## gina_control=controlled 16.73640 26.200873 37.836412 2.033886e-09
## Ever_rhinitis=No 15.44850 20.305677 31.767810 5.227330e-10
## severe_asthma=No 21.09572 73.144105 83.799472 1.129165e-11
## smoking_exposure_at_home=No 15.57719 24.454148 37.941953 3.098246e-12
## education=primary 16.81319 33.406114 48.021108 4.522321e-13
## Recurrent_wheeze=No 20.17544 65.283843 78.205805 1.236431e-13
## Hosptalization_last_year=No 22.28381 87.772926 95.197889 8.396945e-15
## Emergency_last_year=No 20.64191 71.615721 83.852243 7.898957e-15
## Cough=No 17.74065 48.689956 66.332454 2.363067e-19
## smoking_exposure_at_work=No 16.62315 41.703057 60.633245 4.289293e-21
## Chronic_productive_cough=No 18.86024 60.698690 77.783641 3.962157e-22
## smoking_status=never smoker 14.67444 32.969432 54.300792 5.196301e-26
## familial_allergy=Yes 13.24004 26.855895 49.023747 2.065134e-28
## dyspenea=No 17.07152 55.240175 78.205805 1.685373e-38
## spt_any=Yes 14.42308 39.301310 65.857520 2.167292e-41
## XCOPD=No 18.36858 66.375546 87.335092 3.896970e-46
## v.test
## XCOPD=Yes 14.259777
## spt_any=No 13.475933
## dyspenea=Yes 12.975480
## education=tertiary 12.744603
## familial_allergy=No 11.055357
## Chronic_productive_cough=Yes 9.672087
## smoking_exposure_at_work=Yes 9.425287
## Cough=Yes 8.994965
## Emergency_last_year=Yes 7.769190
## Hosptalization_last_year=Yes 7.761441
## Recurrent_wheeze=Yes 7.412818
## smoking_exposure_at_home=Yes 6.973194
## severe_asthma=Yes 6.788996
## smoking_status=former smokers 6.704922
## smoking_status=current smoker 6.493131
## Ever_rhinitis=Yes 6.212124
## gina_steps=step4 or 5 5.171162
## gina_control=uncontrolled 4.751543
## urbanization_level=No 4.488486
## allergen_triggered_asthma=No 3.455104
## Drug_induced_dyspnea=Yes 2.645863
## nasal_plyposis=Yes 2.302090
## Breathlessness=Yes 2.227589
## weather_triggered_asthma=No 2.224166
## gina_control=partially controlled 2.190219
## household_damage=No 2.057414
## education=secondary -1.981794
## household_damage=Yes -2.057414
## weather_triggered_asthma=Yes -2.224166
## Breathlessness=No -2.227589
## nasal_plyposis=No -2.302090
## Drug_induced_dyspnea=No -2.645863
## allergen_triggered_asthma=Yes -3.455104
## urbanization_level=Yes -4.488486
## gina_control=controlled -5.995077
## Ever_rhinitis=No -6.212124
## severe_asthma=No -6.788996
## smoking_exposure_at_home=No -6.973194
## education=primary -7.238932
## Recurrent_wheeze=No -7.412818
## Hosptalization_last_year=No -7.761441
## Emergency_last_year=No -7.769190
## Cough=No -8.994965
## smoking_exposure_at_work=No -9.425287
## Chronic_productive_cough=No -9.672087
## smoking_status=never smoker -10.547868
## familial_allergy=Yes -11.055357
## dyspenea=No -12.975480
## spt_any=Yes -13.475933
## XCOPD=No -14.259777
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=Yes 44.329004 93.944954 60.949868 1.670188e-92
## exertion_triggered_asthma=Yes 43.218197 94.128440 62.638522 2.351936e-86
## weather_triggered_asthma=Yes 52.066116 57.798165 31.926121 3.955456e-51
## allergen_triggered_asthma=Yes 43.862816 44.587156 29.234828 6.388608e-20
## irritant_triggered_asthma=Yes 50.530035 26.238532 14.934037 4.204323e-17
## Gender=Yes 34.217507 71.009174 59.683377 1.044823e-10
## familial_allergy=Yes 35.091496 59.816514 49.023747 2.284110e-09
## Breathlessness=Yes 32.498042 76.146789 67.387863 1.544692e-07
## emotion_triggered_asthma=Yes 45.398773 13.577982 8.601583 2.416453e-06
## smoking_status=never smoker 33.236152 62.752294 54.300792 2.499582e-06
## education=primary 33.736264 56.330275 48.021108 4.304610e-06
## gina_steps=step 1 or 2 38.575668 23.853211 17.783641 1.770873e-05
## XCOPD=No 30.332326 92.110092 87.335092 3.935851e-05
## smoking_exposure_at_work=No 31.766754 66.972477 60.633245 3.099530e-04
## gina_control=partially controlled 32.735426 53.577982 47.071240 3.188451e-04
## urbanization_level=No 31.643002 57.247706 52.031662 3.877199e-03
## Hosptalization_last_year=No 29.379157 97.247706 95.197889 5.938770e-03
## gina_steps=step3 40.625000 7.155963 5.065963 1.071815e-02
## nasal_plyposis=No 31.034483 61.100917 56.622691 1.234240e-02
## household_damage=Yes 35.714286 15.596330 12.559367 1.277763e-02
## Cough=Yes 31.974922 37.431193 33.667546 2.844286e-02
## Cough=No 27.128083 62.568807 66.332454 2.844286e-02
## household_damage=No 27.761014 84.403670 87.440633 1.277763e-02
## nasal_plyposis=Yes 25.790754 38.899083 43.377309 1.234240e-02
## Hosptalization_last_year=Yes 16.483516 2.752294 4.802111 5.938770e-03
## smoking_status=former smokers 24.892704 31.926606 36.886544 4.299357e-03
## urbanization_level=Yes 25.632563 42.752294 47.968338 3.877199e-03
## gina_control=controlled 24.825662 32.660550 37.836412 3.035902e-03
## smoking_status=current smoker 17.365269 5.321101 8.812665 4.081052e-04
## smoking_exposure_at_work=Yes 24.128686 33.027523 39.366755 3.099530e-04
## XCOPD=Yes 17.916667 7.889908 12.664908 3.935851e-05
## emotion_triggered_asthma=No 27.193995 86.422018 91.398417 2.416453e-06
## Breathlessness=No 21.035599 23.853211 32.612137 1.544692e-07
## gina_steps=onlys saba or non users 24.551832 57.798165 67.704485 7.340433e-09
## familial_allergy=No 22.670807 40.183486 50.976253 2.284110e-09
## Gender=No 20.680628 28.990826 40.316623 1.044823e-10
## education=tertiary 9.745763 4.220183 12.453826 6.659516e-14
## irritant_triggered_asthma=No 24.937965 73.761468 85.065963 4.204323e-17
## allergen_triggered_asthma=No 22.520507 55.412844 70.765172 6.388608e-20
## weather_triggered_asthma=No 17.829457 42.201835 68.073879 3.955456e-51
## exertion_triggered_asthma=No 4.519774 5.871560 37.361478 2.351936e-86
## infection_triggered_asthma=No 4.459459 6.055046 39.050132 1.670188e-92
## v.test
## infection_triggered_asthma=Yes 20.400058
## exertion_triggered_asthma=Yes 19.695600
## weather_triggered_asthma=Yes 15.040997
## allergen_triggered_asthma=Yes 9.137545
## irritant_triggered_asthma=Yes 8.407055
## Gender=Yes 6.460319
## familial_allergy=Yes 5.976194
## Breathlessness=Yes 5.247151
## emotion_triggered_asthma=Yes 4.715055
## smoking_status=never smoker 4.708164
## education=primary 4.596105
## gina_steps=step 1 or 2 4.291980
## XCOPD=No 4.111213
## smoking_exposure_at_work=No 3.606836
## gina_control=partially controlled 3.599487
## urbanization_level=No 2.887984
## Hosptalization_last_year=No 2.751143
## gina_steps=step3 2.551756
## nasal_plyposis=No 2.502200
## household_damage=Yes 2.489908
## Cough=Yes 2.191123
## Cough=No -2.191123
## household_damage=No -2.489908
## nasal_plyposis=Yes -2.502200
## Hosptalization_last_year=Yes -2.751143
## smoking_status=former smokers -2.855319
## urbanization_level=Yes -2.887984
## gina_control=controlled -2.964079
## smoking_status=current smoker -3.534786
## smoking_exposure_at_work=Yes -3.606836
## XCOPD=Yes -4.111213
## emotion_triggered_asthma=No -4.715055
## Breathlessness=No -5.247151
## gina_steps=onlys saba or non users -5.782944
## familial_allergy=No -5.976194
## Gender=No -6.460319
## education=tertiary -7.494414
## irritant_triggered_asthma=No -8.407055
## allergen_triggered_asthma=No -9.137545
## weather_triggered_asthma=No -15.040997
## exertion_triggered_asthma=No -19.695600
## infection_triggered_asthma=No -20.400058
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## Breathlessness=Yes 24.667189 87.988827 67.387863 6.118216e-23
## exertion_triggered_asthma=Yes 23.757372 78.770950 62.638522 5.007444e-13
## infection_triggered_asthma=Yes 23.636364 76.256983 60.949868 1.420112e-11
## Gender=No 25.000000 53.351955 40.316623 3.231222e-08
## allergen_triggered_asthma=Yes 26.714801 41.340782 29.234828 4.986392e-08
## spt_any=Yes 22.195513 77.374302 65.857520 1.726375e-07
## weather_triggered_asthma=Yes 24.132231 40.782123 31.926121 8.637473e-05
## dyspenea=No 20.647773 85.474860 78.205805 1.347549e-04
## emotion_triggered_asthma=Yes 30.674847 13.966480 8.601583 1.481752e-04
## XCOPD=No 20.060423 92.737430 87.335092 3.401466e-04
## Recurrent_wheeze=Yes 24.939467 28.770950 21.794195 5.386597e-04
## gina_steps=step 1 or 2 24.629080 23.184358 17.783641 3.841791e-03
## nasal_plyposis=Yes 21.411192 49.162011 43.377309 1.461251e-02
## Cough=No 20.365951 71.508380 66.332454 2.050916e-02
## irritant_triggered_asthma=Yes 23.674912 18.715084 14.934037 2.924364e-02
## smoking_status=never smoker 20.602527 59.217877 54.300792 3.801280e-02
## Hosptalization_last_year=No 19.290466 97.206704 95.197889 4.071512e-02
## Hosptalization_last_year=Yes 10.989011 2.793296 4.802111 4.071512e-02
## irritant_triggered_asthma=No 18.052109 81.284916 85.065963 2.924364e-02
## Cough=Yes 15.987461 28.491620 33.667546 2.050916e-02
## nasal_plyposis=No 16.961789 50.837989 56.622691 1.461251e-02
## gina_control=controlled 15.760112 31.564246 37.836412 6.238874e-03
## Recurrent_wheeze=No 17.206478 71.229050 78.205805 5.386597e-04
## gina_steps=onlys saba or non users 16.679657 59.776536 67.704485 4.473595e-04
## XCOPD=Yes 10.833333 7.262570 12.664908 3.401466e-04
## emotion_triggered_asthma=No 17.782910 86.033520 91.398417 1.481752e-04
## dyspenea=Yes 12.590799 14.525140 21.794195 1.347549e-04
## weather_triggered_asthma=No 16.434109 59.217877 68.073879 8.637473e-05
## spt_any=No 12.519320 22.625698 34.142480 1.726375e-07
## allergen_triggered_asthma=No 15.659955 58.659218 70.765172 4.986392e-08
## Gender=Yes 14.765694 46.648045 59.683377 3.231222e-08
## infection_triggered_asthma=No 11.486486 23.743017 39.050132 1.420112e-11
## exertion_triggered_asthma=No 10.734463 21.229050 37.361478 5.007444e-13
## Breathlessness=No 6.957929 12.011173 32.612137 6.118216e-23
## v.test
## Breathlessness=Yes 9.861413
## exertion_triggered_asthma=Yes 7.225097
## infection_triggered_asthma=Yes 6.755839
## Gender=No 5.528423
## allergen_triggered_asthma=Yes 5.451795
## spt_any=Yes 5.226619
## weather_triggered_asthma=Yes 3.925987
## dyspenea=No 3.817602
## emotion_triggered_asthma=Yes 3.794108
## XCOPD=No 3.582634
## Recurrent_wheeze=Yes 3.460757
## gina_steps=step 1 or 2 2.890868
## nasal_plyposis=Yes 2.441843
## Cough=No 2.316900
## irritant_triggered_asthma=Yes 2.180186
## smoking_status=never smoker 2.074717
## Hosptalization_last_year=No 2.046419
## Hosptalization_last_year=Yes -2.046419
## irritant_triggered_asthma=No -2.180186
## Cough=Yes -2.316900
## nasal_plyposis=No -2.441843
## gina_control=controlled -2.734955
## Recurrent_wheeze=No -3.460757
## gina_steps=onlys saba or non users -3.510444
## XCOPD=Yes -3.582634
## emotion_triggered_asthma=No -3.794108
## dyspenea=Yes -3.817602
## weather_triggered_asthma=No -3.925987
## spt_any=No -5.226619
## allergen_triggered_asthma=No -5.451795
## Gender=Yes -5.528423
## infection_triggered_asthma=No -6.755839
## exertion_triggered_asthma=No -7.225097
## Breathlessness=No -9.861413
##
## $`3`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=No 61.891892 85.7677903 39.050132 6.262560e-156
## exertion_triggered_asthma=No 59.887006 79.4007491 37.361478 4.536504e-125
## weather_triggered_asthma=No 40.077519 96.8164794 68.073879 3.679263e-80
## Breathlessness=No 50.970874 58.9887640 32.612137 3.889537e-51
## allergen_triggered_asthma=No 35.495899 89.1385768 70.765172 1.212445e-31
## gina_control=controlled 42.677824 57.3033708 37.836412 2.478760e-27
## gina_steps=onlys saba or non users 35.463757 85.2059925 67.704485 1.445086e-26
## irritant_triggered_asthma=No 32.258065 97.3782772 85.065963 1.531390e-26
## severe_asthma=No 32.367758 96.2546816 83.799472 1.159399e-24
## Recurrent_wheeze=No 32.995951 91.5730337 78.205805 3.833340e-21
## emotion_triggered_asthma=No 30.658199 99.4382022 91.398417 1.325358e-20
## Cough=No 34.765314 81.8352060 66.332454 2.353654e-20
## dyspenea=No 32.860999 91.1985019 78.205805 5.950031e-20
## Chronic_productive_cough=No 32.700136 90.2621723 77.783641 4.324469e-18
## XCOPD=No 31.238671 96.8164794 87.335092 6.109505e-18
## urbanization_level=Yes 36.963696 62.9213483 47.968338 2.904197e-16
## spt_any=Yes 33.814103 79.0262172 65.857520 8.291653e-15
## Ever_rhinitis=No 38.538206 43.4456929 31.767810 1.657505e-11
## smoking_exposure_at_home=No 35.744089 48.1273408 37.941953 1.387204e-08
## smoking_exposure_at_work=No 32.637076 70.2247191 60.633245 6.424268e-08
## Emergency_last_year=No 30.522341 90.8239700 83.852243 7.134402e-08
## Hosptalization_last_year=No 29.046563 98.1273408 95.197889 6.024807e-05
## smoking_status=never smoker 31.486880 60.6741573 54.300792 4.745994e-04
## Gender=No 32.329843 46.2546816 40.316623 1.019796e-03
## familial_allergy=Yes 31.431647 54.6816479 49.023747 2.048391e-03
## education=secondary 31.108144 43.6329588 39.525066 2.247759e-02
## gina_steps=step3 18.750000 3.3707865 5.065963 3.103044e-02
## smoking_status=former smokers 24.749642 32.3970037 36.886544 1.089278e-02
## familial_allergy=No 25.051760 45.3183521 50.976253 2.048391e-03
## Gender=Yes 25.375774 53.7453184 59.683377 1.019796e-03
## Hosptalization_last_year=Yes 10.989011 1.8726592 4.802111 6.024807e-05
## education=tertiary 15.677966 6.9288390 12.453826 1.824253e-06
## gina_control=uncontrolled 15.734266 8.4269663 15.092348 1.129107e-07
## Emergency_last_year=Yes 16.013072 9.1760300 16.147757 7.134402e-08
## smoking_exposure_at_work=Yes 21.313673 29.7752809 39.366755 6.424268e-08
## gina_steps=step 1 or 2 16.320475 10.2996255 17.783641 2.802448e-08
## smoking_exposure_at_home=Yes 23.554422 51.8726592 62.058047 1.387204e-08
## Ever_rhinitis=Yes 23.356535 56.5543071 68.232190 1.657505e-11
## gina_control=partially controlled 20.515695 34.2696629 47.071240 1.985952e-12
## spt_any=No 17.310665 20.9737828 34.142480 8.291653e-15
## urbanization_level=No 20.081136 37.0786517 52.031662 2.904197e-16
## XCOPD=Yes 7.083333 3.1835206 12.664908 6.109505e-18
## Chronic_productive_cough=Yes 12.351544 9.7378277 22.216359 4.324469e-18
## gina_steps=step4 or 5 3.351955 1.1235955 9.445910 2.076713e-19
## dyspenea=Yes 11.380145 8.8014981 21.794195 5.950031e-20
## Cough=Yes 15.203762 18.1647940 33.667546 2.353654e-20
## emotion_triggered_asthma=Yes 1.840491 0.5617978 8.601583 1.325358e-20
## Recurrent_wheeze=Yes 10.895884 8.4269663 21.794195 3.833340e-21
## severe_asthma=Yes 6.514658 3.7453184 16.200528 1.159399e-24
## irritant_triggered_asthma=Yes 4.946996 2.6217228 14.934037 1.531390e-26
## allergen_triggered_asthma=Yes 10.469314 10.8614232 29.234828 1.212445e-31
## Breathlessness=Yes 17.149569 41.0112360 67.387863 3.889537e-51
## weather_triggered_asthma=Yes 2.809917 3.1835206 31.926121 3.679263e-80
## exertion_triggered_asthma=Yes 9.267060 20.5992509 62.638522 4.536504e-125
## infection_triggered_asthma=Yes 6.580087 14.2322097 60.949868 6.262560e-156
## v.test
## infection_triggered_asthma=No 26.603025
## exertion_triggered_asthma=No 23.787151
## weather_triggered_asthma=No 18.959601
## Breathlessness=No 15.042110
## allergen_triggered_asthma=No 11.704237
## gina_control=controlled 10.830103
## gina_steps=onlys saba or non users 10.667469
## irritant_triggered_asthma=No 10.662077
## severe_asthma=No 10.251983
## Recurrent_wheeze=No 9.437074
## emotion_triggered_asthma=No 9.306161
## Cough=No 9.244943
## dyspenea=No 9.145235
## Chronic_productive_cough=No 8.669914
## XCOPD=No 8.630480
## urbanization_level=Yes 8.177240
## spt_any=Yes 7.763041
## Ever_rhinitis=No 6.733394
## smoking_exposure_at_home=No 5.674961
## smoking_exposure_at_work=No 5.406571
## Emergency_last_year=No 5.387753
## Hosptalization_last_year=No 4.011837
## smoking_status=never smoker 3.494697
## Gender=No 3.285008
## familial_allergy=Yes 3.083125
## education=secondary 2.282199
## gina_steps=step3 -2.156682
## smoking_status=former smokers -2.546120
## familial_allergy=No -3.083125
## Gender=Yes -3.285008
## Hosptalization_last_year=Yes -4.011837
## education=tertiary -4.771978
## gina_control=uncontrolled -5.304616
## Emergency_last_year=Yes -5.387753
## smoking_exposure_at_work=Yes -5.406571
## gina_steps=step 1 or 2 -5.553351
## smoking_exposure_at_home=Yes -5.674961
## Ever_rhinitis=Yes -6.733394
## gina_control=partially controlled -7.035467
## spt_any=No -7.763041
## urbanization_level=No -8.177240
## XCOPD=Yes -8.630480
## Chronic_productive_cough=Yes -8.669914
## gina_steps=step4 or 5 -9.009144
## dyspenea=Yes -9.145235
## Cough=Yes -9.244943
## emotion_triggered_asthma=Yes -9.306161
## Recurrent_wheeze=Yes -9.437074
## severe_asthma=Yes -10.251983
## irritant_triggered_asthma=Yes -10.662077
## allergen_triggered_asthma=Yes -11.704237
## Breathlessness=Yes -15.042110
## weather_triggered_asthma=Yes -18.959601
## exertion_triggered_asthma=Yes -23.787151
## infection_triggered_asthma=Yes -26.603025
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## FeNO 0.396449606 1.010534e-206
## pack_years 0.367395337 1.968308e-187
## Age 0.354531074 3.571377e-179
## tlco 0.291488499 5.974798e-141
## kco 0.269721979 1.529881e-128
## Eosinophiles 0.267284265 3.557168e-127
## onset_age_asthma 0.227411686 1.881929e-105
## FEV1_FVC_ratio_post 0.192278082 3.158492e-87
## Reversibility 0.127464867 1.273413e-55
## Basophiles 0.081835141 8.729116e-35
## Neutrophiles 0.075234716 7.315771e-32
## pd20 0.064965600 2.331042e-27
## Monocytes 0.056507476 1.085198e-23
## BMI 0.048590220 2.721032e-20
## Lymphocytes 0.006100126 8.995633e-03
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## pack_years 26.307439 2.706924e+01 1.194451e+01 1.875875e+01
## Age 25.073868 6.575328e+01 4.971821e+01 9.270454e+00
## onset_age_asthma 19.595178 3.510480e+01 2.149024e+01 1.934862e+01
## Neutrophiles 11.048420 4.477882e+00 3.856132e+00 1.626531e+00
## pd20 10.804135 2.987810e+03 1.952471e+03 1.991958e+03
## Monocytes 8.919992 4.824017e-01 4.264011e-01 1.925261e-01
## BMI 7.485434 2.854819e+01 2.706171e+01 4.959407e+00
## Reversibility 4.143543 8.627461e+00 7.333086e+00 8.483735e+00
## Basophiles 3.881247 3.864629e-02 3.133509e-02 5.019962e-02
## Lymphocytes 3.091799 2.068755e+00 1.982802e+00 9.452106e-01
## FeNO -7.139580 1.900579e+01 2.550929e+01 1.157200e+01
## FEV1_FVC_ratio_post -17.060220 7.032448e-01 7.699727e-01 1.121804e-01
## kco -22.158179 8.504850e+01 9.897243e+01 1.428291e+01
## tlco -23.451193 8.280686e+01 1.001420e+02 1.453755e+01
## Overall sd p.value
## pack_years 1.412548e+01 1.576458e-152
## Age 1.571245e+01 9.589752e-139
## onset_age_asthma 1.707061e+01 1.699898e-85
## Neutrophiles 1.382643e+00 2.231059e-28
## pd20 2.354436e+03 3.290434e-27
## Monocytes 1.542493e-01 4.663209e-19
## BMI 4.879071e+00 7.131089e-14
## Reversibility 7.675073e+00 3.419806e-05
## Basophiles 4.628193e-02 1.039221e-04
## Lymphocytes 6.830395e-01 1.989473e-03
## FeNO 2.238045e+01 9.361619e-13
## FEV1_FVC_ratio_post 9.609862e-02 2.934485e-65
## kco 1.543910e+01 8.699863e-109
## tlco 1.816168e+01 1.285375e-121
##
## $`1`
## v.test Mean in category Overall mean sd in category
## kco 11.740831 105.52783477 98.97243082 12.84461695
## tlco 9.692937 106.50831535 100.14197170 17.79668925
## FEV1_FVC_ratio_post 7.533644 0.79615457 0.76997268 0.06565980
## BMI 2.571213 27.51538966 27.06170516 5.15591881
## Monocytes -4.216396 0.40288073 0.42640106 0.12534120
## Reversibility -5.419222 5.82891203 7.33308613 5.39452663
## Basophiles -5.840460 0.02155963 0.03133509 0.03990296
## onset_age_asthma -6.040014 17.76146789 21.49023747 12.51281844
## Eosinophiles -8.524441 0.16884404 0.21963588 0.09427436
## FeNO -8.617435 18.53458716 25.50928760 12.31400862
## Age -8.849087 44.68990826 49.71820580 12.28250001
## pack_years -9.657892 7.01090367 11.94450818 6.78389916
## Overall sd p.value
## kco 15.43910033 7.870958e-32
## tlco 18.16168128 3.231017e-22
## FEV1_FVC_ratio_post 0.09609862 4.934344e-14
## BMI 4.87907144 1.013429e-02
## Monocytes 0.15424932 2.482381e-05
## Reversibility 7.67507328 5.985901e-08
## Basophiles 0.04628193 5.205681e-09
## onset_age_asthma 17.07060566 1.541005e-09
## Eosinophiles 0.16475912 1.535496e-17
## FeNO 22.38045429 6.847061e-18
## Age 15.71244775 8.823798e-19
## pack_years 14.12548389 4.551318e-22
##
## $`2`
## v.test Mean in category Overall mean sd in category
## FeNO 27.399921 5.470531e+01 2.550929e+01 3.266443e+01
## Eosinophiles 21.988800 3.921229e-01 2.196359e-01 2.324679e-01
## Reversibility 13.041905 1.209881e+01 7.333086e+00 1.052113e+01
## Basophiles 10.308594 5.405028e-02 3.133509e-02 5.141101e-02
## tlco 6.214054 1.055152e+02 1.001420e+02 1.425384e+01
## kco 5.852116 1.032741e+02 9.897243e+01 1.360505e+01
## Monocytes 2.445078 4.443575e-01 4.264011e-01 1.484106e-01
## BMI -2.699464 2.643463e+01 2.706171e+01 4.341344e+00
## Neutrophiles -2.800361 3.671788e+00 3.856132e+00 1.226755e+00
## FEV1_FVC_ratio_post -3.238340 7.551562e-01 7.699727e-01 1.023261e-01
## pd20 -4.639887 1.432356e+03 1.952471e+03 1.613508e+03
## pack_years -5.410500 8.305809e+00 1.194451e+01 8.344884e+00
## Overall sd p.value
## FeNO 2.238045e+01 2.748446e-165
## Eosinophiles 1.647591e-01 3.686051e-107
## Reversibility 7.675073e+00 7.066883e-39
## Basophiles 4.628193e-02 6.443724e-25
## tlco 1.816168e+01 5.163471e-10
## kco 1.543910e+01 4.853586e-09
## Monocytes 1.542493e-01 1.448209e-02
## BMI 4.879071e+00 6.945137e-03
## Neutrophiles 1.382643e+00 5.104549e-03
## FEV1_FVC_ratio_post 9.609862e-02 1.202274e-03
## pd20 2.354436e+03 3.486004e-06
## pack_years 1.412548e+01 6.284891e-08
##
## $`3`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 11.472485 8.104157e-01 7.699727e-01 6.525006e-02
## tlco 7.156938 1.049101e+02 1.001420e+02 1.373360e+01
## kco 4.180914 1.013403e+02 9.897243e+01 1.225930e+01
## Lymphocytes -2.064751 1.931067e+00 1.982802e+00 5.431506e-01
## pd20 -4.592244 1.555846e+03 1.952471e+03 2.555227e+03
## Monocytes -6.373558 3.903371e-01 4.264011e-01 1.306562e-01
## Basophiles -6.786744 1.981273e-02 3.133509e-02 3.769534e-02
## BMI -7.361442 2.574415e+01 2.706171e+01 4.417150e+00
## Neutrophiles -7.783232 3.461367e+00 3.856132e+00 1.120808e+00
## FeNO -8.376577 1.863221e+01 2.550929e+01 9.374641e+00
## Eosinophiles -9.197846 1.640449e-01 2.196359e-01 1.030478e-01
## Reversibility -9.838487 4.563089e+00 7.333086e+00 4.093268e+00
## pack_years -10.609433 6.447024e+00 1.194451e+01 7.243138e+00
## onset_age_asthma -12.574344 1.361610e+01 2.149024e+01 1.076966e+01
## Age -13.842332 4.173970e+01 4.971821e+01 1.395356e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 9.609862e-02 1.813742e-30
## tlco 1.816168e+01 8.249927e-13
## kco 1.543910e+01 2.903398e-05
## Lymphocytes 6.830395e-01 3.894660e-02
## pd20 2.354436e+03 4.385043e-06
## Monocytes 1.542493e-01 1.846929e-10
## Basophiles 4.628193e-02 1.146924e-11
## BMI 4.879071e+00 1.819346e-13
## Neutrophiles 1.382643e+00 7.069455e-15
## FeNO 2.238045e+01 5.448915e-17
## Eosinophiles 1.647591e-01 3.651980e-20
## Reversibility 7.675073e+00 7.685767e-23
## pack_years 1.412548e+01 2.693784e-26
## onset_age_asthma 1.707061e+01 2.922147e-36
## Age 1.571245e+01 1.415397e-431.5.3 Radar Plots
1.5.4 parallel box plots
1.5.5 parallel coordinate plot
## Deep Empedding Clustering on the asthmatic encoded data 3 clusters
{.tabset}
1.5.6 Summary table
# results_Kam <- get_ClusterResults(OriginalData = my_imp_data, Labels = kamRes$finalMemb)
table_result <- tableby(clusters ~ ., data = as.list(results_cluster_data))
summary(table_result, title = "Charachtaristcs of Clusters") | 0 (N=559) | 1 (N=656) | 2 (N=680) | Total (N=1895) | p value | |
|---|---|---|---|---|---|
| Age | < 0.001 | ||||
| Â Â Â Mean (SD) | 65.052 (9.199) | 42.290 (13.678) | 44.279 (12.747) | 49.718 (15.717) | |
| Â Â Â Range | 28.000 - 86.000 | 17.000 - 97.000 | 18.000 - 78.000 | 17.000 - 97.000 | |
| Gender | 0.068 | ||||
| Â Â Â No | 221 (39.5%) | 287 (43.8%) | 256 (37.6%) | 764 (40.3%) | |
| Â Â Â Yes | 338 (60.5%) | 369 (56.2%) | 424 (62.4%) | 1131 (59.7%) | |
| BMI | < 0.001 | ||||
| Â Â Â Mean (SD) | 28.041 (4.807) | 25.666 (4.263) | 27.602 (5.191) | 27.062 (4.880) | |
| Â Â Â Range | 17.603 - 48.870 | 17.029 - 46.094 | 17.509 - 50.058 | 17.029 - 50.058 | |
| age at asthma onset as numeeric variable | < 0.001 | ||||
| Â Â Â Mean (SD) | 35.342 (18.937) | 14.855 (11.873) | 16.504 (12.538) | 21.490 (17.075) | |
| Â Â Â Range | 1.000 - 72.000 | -1.000 - 62.000 | -1.000 - 68.000 | -1.000 - 72.000 | |
| Cough | < 0.001 | ||||
| Â Â Â No | 291 (52.1%) | 524 (79.9%) | 442 (65.0%) | 1257 (66.3%) | |
| Â Â Â Yes | 268 (47.9%) | 132 (20.1%) | 238 (35.0%) | 638 (33.7%) | |
| Breathlessness | < 0.001 | ||||
| Â Â Â No | 174 (31.1%) | 344 (52.4%) | 100 (14.7%) | 618 (32.6%) | |
| Â Â Â Yes | 385 (68.9%) | 312 (47.6%) | 580 (85.3%) | 1277 (67.4%) | |
| Recurrent_wheeze | < 0.001 | ||||
| Â Â Â No | 381 (68.2%) | 595 (90.7%) | 506 (74.4%) | 1482 (78.2%) | |
| Â Â Â Yes | 178 (31.8%) | 61 (9.3%) | 174 (25.6%) | 413 (21.8%) | |
| dyspenea | < 0.001 | ||||
| Â Â Â No | 325 (58.1%) | 596 (90.9%) | 561 (82.5%) | 1482 (78.2%) | |
| Â Â Â Yes | 234 (41.9%) | 60 (9.1%) | 119 (17.5%) | 413 (21.8%) | |
| Chronic_productive_cough | < 0.001 | ||||
| Â Â Â No | 348 (62.3%) | 592 (90.2%) | 534 (78.5%) | 1474 (77.8%) | |
| Â Â Â Yes | 211 (37.7%) | 64 (9.8%) | 146 (21.5%) | 421 (22.2%) | |
| FEV1_FVC_ratio_post | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.710 (0.119) | 0.806 (0.066) | 0.784 (0.075) | 0.770 (0.096) | |
| Â Â Â Range | 0.230 - 1.590 | 0.557 - 1.009 | 0.524 - 1.000 | 0.230 - 1.590 | |
| Reversibility | < 0.001 | ||||
| Â Â Â Mean (SD) | 9.400 (9.882) | 4.687 (4.788) | 8.187 (7.143) | 7.333 (7.677) | |
| Â Â Â Range | -12.121 - 77.242 | -26.774 - 35.757 | -9.470 - 53.704 | -26.774 - 77.242 | |
| pd20 | < 0.001 | ||||
| Â Â Â Mean (SD) | 2870.432 (1995.504) | 1707.770 (2894.928) | 1433.918 (1758.732) | 1952.471 (2355.058) | |
| Â Â Â Range | 0.059 - 13923.750 | -26261.250 - 38775.000 | -2562.590 - 19387.500 | -26261.250 - 38775.000 | |
| tlco | < 0.001 | ||||
| Â Â Â Mean (SD) | 84.785 (14.530) | 104.451 (12.595) | 108.610 (17.611) | 100.142 (18.166) | |
| Â Â Â Range | 44.453 - 136.837 | 63.818 - 148.214 | 68.403 - 389.709 | 44.453 - 389.709 | |
| kco | < 0.001 | ||||
| Â Â Â Mean (SD) | 86.714 (14.512) | 101.101 (11.865) | 106.997 (12.798) | 98.972 (15.443) | |
| Â Â Â Range | 40.972 - 139.418 | 69.866 - 142.603 | 60.955 - 149.720 | 40.972 - 149.720 | |
| FeNO | < 0.001 | ||||
| Â Â Â Mean (SD) | 23.508 (21.201) | 19.964 (12.262) | 32.504 (28.311) | 25.509 (22.386) | |
| Â Â Â Range | 3.600 - 168.000 | 3.300 - 96.000 | 5.000 - 226.000 | 3.300 - 226.000 | |
| Eosinophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.242 (0.189) | 0.166 (0.107) | 0.253 (0.176) | 0.220 (0.165) | |
| Â Â Â Range | 0.000 - 2.300 | 0.000 - 0.900 | 0.000 - 1.200 | 0.000 - 2.300 | |
| Neutrophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 4.362 (1.580) | 3.410 (1.074) | 3.871 (1.330) | 3.856 (1.383) | |
| Â Â Â Range | 1.300 - 12.500 | 1.300 - 7.200 | 1.000 - 10.600 | 1.000 - 12.500 | |
| Lymphocyties | < 0.001 | ||||
| Â Â Â Mean (SD) | 2.075 (0.909) | 1.906 (0.544) | 1.981 (0.570) | 1.983 (0.683) | |
| Â Â Â Range | 0.300 - 11.200 | 0.600 - 4.100 | 0.600 - 5.000 | 0.300 - 11.200 | |
| Monocytes | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.475 (0.185) | 0.379 (0.123) | 0.431 (0.140) | 0.426 (0.154) | |
| Â Â Â Range | 0.200 - 2.400 | 0.200 - 1.000 | 0.200 - 1.100 | 0.200 - 2.400 | |
| Basophiles | < 0.001 | ||||
| Â Â Â Mean (SD) | 0.039 (0.050) | 0.015 (0.034) | 0.041 (0.050) | 0.031 (0.046) | |
| Â Â Â Range | 0.000 - 0.300 | 0.000 - 0.190 | 0.000 - 0.200 | 0.000 - 0.300 | |
| spt_any | < 0.001 | ||||
| Â Â Â No | 319 (57.1%) | 171 (26.1%) | 157 (23.1%) | 647 (34.1%) | |
| Â Â Â Yes | 240 (42.9%) | 485 (73.9%) | 523 (76.9%) | 1248 (65.9%) | |
| familial_allergy | < 0.001 | ||||
| Â Â Â No | 386 (69.1%) | 325 (49.5%) | 255 (37.5%) | 966 (51.0%) | |
| Â Â Â Yes | 173 (30.9%) | 331 (50.5%) | 425 (62.5%) | 929 (49.0%) | |
| Drug_induced_dyspnea | 0.299 | ||||
| Â Â Â No | 521 (93.2%) | 625 (95.3%) | 641 (94.3%) | 1787 (94.3%) | |
| Â Â Â Yes | 38 (6.8%) | 31 (4.7%) | 39 (5.7%) | 108 (5.7%) | |
| nasal_plyposis | 0.001 | ||||
| Â Â Â No | 281 (50.3%) | 384 (58.5%) | 408 (60.0%) | 1073 (56.6%) | |
| Â Â Â Yes | 278 (49.7%) | 272 (41.5%) | 272 (40.0%) | 822 (43.4%) | |
| Ever_rhinitis | < 0.001 | ||||
| Â Â Â No | 127 (22.7%) | 257 (39.2%) | 218 (32.1%) | 602 (31.8%) | |
| Â Â Â Yes | 432 (77.3%) | 399 (60.8%) | 462 (67.9%) | 1293 (68.2%) | |
| gina_steps | < 0.001 | ||||
| Â Â Â onlys saba or non users | 361 (64.6%) | 555 (84.6%) | 367 (54.0%) | 1283 (67.7%) | |
| Â Â Â step 1 or 2 | 88 (15.7%) | 75 (11.4%) | 174 (25.6%) | 337 (17.8%) | |
| Â Â Â step3 | 25 (4.5%) | 17 (2.6%) | 54 (7.9%) | 96 (5.1%) | |
| Â Â Â step4 or 5 | 85 (15.2%) | 9 (1.4%) | 85 (12.5%) | 179 (9.4%) | |
| Hosptalization_last_year | < 0.001 | ||||
| Â Â Â No | 498 (89.1%) | 644 (98.2%) | 662 (97.4%) | 1804 (95.2%) | |
| Â Â Â Yes | 61 (10.9%) | 12 (1.8%) | 18 (2.6%) | 91 (4.8%) | |
| Emergency_last_year | < 0.001 | ||||
| Â Â Â No | 409 (73.2%) | 599 (91.3%) | 581 (85.4%) | 1589 (83.9%) | |
| Â Â Â Yes | 150 (26.8%) | 57 (8.7%) | 99 (14.6%) | 306 (16.1%) | |
| severe_asthma | < 0.001 | ||||
| Â Â Â No | 424 (75.8%) | 625 (95.3%) | 539 (79.3%) | 1588 (83.8%) | |
| Â Â Â Yes | 135 (24.2%) | 31 (4.7%) | 141 (20.7%) | 307 (16.2%) | |
| gina_control | < 0.001 | ||||
| Â Â Â controlled | 158 (28.3%) | 342 (52.1%) | 217 (31.9%) | 717 (37.8%) | |
| Â Â Â partially controlled | 287 (51.3%) | 261 (39.8%) | 344 (50.6%) | 892 (47.1%) | |
| Â Â Â uncontrolled | 114 (20.4%) | 53 (8.1%) | 119 (17.5%) | 286 (15.1%) | |
| education | < 0.001 | ||||
| Â Â Â primary | 181 (32.4%) | 361 (55.0%) | 368 (54.1%) | 910 (48.0%) | |
| Â Â Â secondary | 214 (38.3%) | 260 (39.6%) | 275 (40.4%) | 749 (39.5%) | |
| Â Â Â tertiary | 164 (29.3%) | 35 (5.3%) | 37 (5.4%) | 236 (12.5%) | |
| urbanization_level | < 0.001 | ||||
| Â Â Â No | 324 (58.0%) | 280 (42.7%) | 382 (56.2%) | 986 (52.0%) | |
| Â Â Â Yes | 235 (42.0%) | 376 (57.3%) | 298 (43.8%) | 909 (48.0%) | |
| smoking_status | < 0.001 | ||||
| Â Â Â never smoker | 173 (30.9%) | 434 (66.2%) | 422 (62.1%) | 1029 (54.3%) | |
| Â Â Â former smokers | 295 (52.8%) | 189 (28.8%) | 215 (31.6%) | 699 (36.9%) | |
| Â Â Â current smoker | 91 (16.3%) | 33 (5.0%) | 43 (6.3%) | 167 (8.8%) | |
| pack_years | < 0.001 | ||||
| Â Â Â Mean (SD) | 25.409 (18.092) | 5.755 (6.031) | 6.847 (6.364) | 11.945 (14.129) | |
| Â Â Â Range | 0.000 - 112.500 | 0.000 - 33.750 | 0.000 - 36.000 | 0.000 - 112.500 | |
| smoking_exposure_at_home | < 0.001 | ||||
| Â Â Â No | 132 (23.6%) | 310 (47.3%) | 277 (40.7%) | 719 (37.9%) | |
| Â Â Â Yes | 427 (76.4%) | 346 (52.7%) | 403 (59.3%) | 1176 (62.1%) | |
| smoking_exposure_at_work | < 0.001 | ||||
| Â Â Â No | 230 (41.1%) | 474 (72.3%) | 445 (65.4%) | 1149 (60.6%) | |
| Â Â Â Yes | 329 (58.9%) | 182 (27.7%) | 235 (34.6%) | 746 (39.4%) | |
| household_damage | 0.003 | ||||
| Â Â Â No | 510 (91.2%) | 557 (84.9%) | 590 (86.8%) | 1657 (87.4%) | |
| Â Â Â Yes | 49 (8.8%) | 99 (15.1%) | 90 (13.2%) | 238 (12.6%) | |
| exertion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 213 (38.1%) | 420 (64.0%) | 75 (11.0%) | 708 (37.4%) | |
| Â Â Â Yes | 346 (61.9%) | 236 (36.0%) | 605 (89.0%) | 1187 (62.6%) | |
| infection_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 207 (37.0%) | 442 (67.4%) | 91 (13.4%) | 740 (39.1%) | |
| Â Â Â Yes | 352 (63.0%) | 214 (32.6%) | 589 (86.6%) | 1155 (60.9%) | |
| allergen_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 432 (77.3%) | 560 (85.4%) | 349 (51.3%) | 1341 (70.8%) | |
| Â Â Â Yes | 127 (22.7%) | 96 (14.6%) | 331 (48.7%) | 554 (29.2%) | |
| irritant_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 485 (86.8%) | 624 (95.1%) | 503 (74.0%) | 1612 (85.1%) | |
| Â Â Â Yes | 74 (13.2%) | 32 (4.9%) | 177 (26.0%) | 283 (14.9%) | |
| weather_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 394 (70.5%) | 604 (92.1%) | 292 (42.9%) | 1290 (68.1%) | |
| Â Â Â Yes | 165 (29.5%) | 52 (7.9%) | 388 (57.1%) | 605 (31.9%) | |
| emotion_triggered_asthma | < 0.001 | ||||
| Â Â Â No | 510 (91.2%) | 652 (99.4%) | 570 (83.8%) | 1732 (91.4%) | |
| Â Â Â Yes | 49 (8.8%) | 4 (0.6%) | 110 (16.2%) | 163 (8.6%) | |
| XCOPD | < 0.001 | ||||
| Â Â Â No | 387 (69.2%) | 630 (96.0%) | 638 (93.8%) | 1655 (87.3%) | |
| Â Â Â Yes | 172 (30.8%) | 26 (4.0%) | 42 (6.2%) | 240 (12.7%) |
1.5.7 Charachtiristic Analysis
##
## Link between the cluster variable and the categorical variables (chi-square test)
## =================================================================================
## p.value df
## infection_triggered_asthma 7.770721e-90 2
## exertion_triggered_asthma 8.920707e-88 2
## weather_triggered_asthma 1.021583e-81 2
## XCOPD 4.557274e-52 2
## Breathlessness 7.153113e-48 2
## education 5.927730e-47 4
## allergen_triggered_asthma 7.120301e-45 2
## dyspenea 2.275136e-44 2
## spt_any 2.990235e-41 2
## smoking_status 3.120667e-39 4
## gina_steps 9.319070e-36 6
## Chronic_productive_cough 1.635677e-30 2
## smoking_exposure_at_work 1.562552e-29 2
## familial_allergy 1.914809e-27 2
## irritant_triggered_asthma 1.193890e-26 2
## Cough 1.267104e-23 2
## emotion_triggered_asthma 4.427578e-23 2
## severe_asthma 1.979200e-22 2
## Recurrent_wheeze 3.258712e-22 2
## gina_control 5.926539e-21 4
## Emergency_last_year 4.317374e-17 2
## smoking_exposure_at_home 4.769782e-17 2
## Hosptalization_last_year 6.802227e-15 2
## Ever_rhinitis 6.332159e-09 2
## urbanization_level 1.931187e-08 2
## nasal_plyposis 1.277352e-03 2
## household_damage 3.281938e-03 2
##
## Description of each cluster by the categories
## =============================================
## $`0`
## Cla/Mod Mod/Cla Global p.value
## XCOPD=Yes 71.66667 30.769231 12.664908 5.944927e-48
## education=tertiary 69.49153 29.338104 12.453826 1.757778e-42
## spt_any=No 49.30448 57.066190 34.142480 5.661621e-41
## dyspenea=Yes 56.65860 41.860465 21.794195 9.563530e-40
## smoking_exposure_at_work=Yes 44.10188 58.855098 39.366755 7.243320e-29
## familial_allergy=No 39.95859 69.051878 50.976253 9.550156e-25
## Chronic_productive_cough=Yes 50.11876 37.745975 22.216359 2.267578e-24
## smoking_status=former smokers 42.20315 52.772809 36.886544 4.674902e-20
## smoking_exposure_at_home=Yes 36.30952 76.386404 62.058047 2.160771e-17
## Cough=Yes 42.00627 47.942755 33.667546 5.045310e-17
## Emergency_last_year=Yes 49.01961 26.833631 16.147757 3.224529e-15
## Hosptalization_last_year=Yes 67.03297 10.912343 4.802111 3.991604e-14
## smoking_status=current smoker 54.49102 16.279070 8.812665 1.654341e-12
## Recurrent_wheeze=Yes 43.09927 31.842576 21.794195 2.340878e-11
## severe_asthma=Yes 43.97394 24.150268 16.200528 3.743826e-09
## Ever_rhinitis=Yes 33.41067 77.280859 68.232190 2.622019e-08
## gina_steps=step4 or 5 47.48603 15.205725 9.445910 9.880220e-08
## allergen_triggered_asthma=No 32.21477 77.280859 70.765172 4.409344e-05
## gina_control=uncontrolled 39.86014 20.393560 15.092348 4.659714e-05
## nasal_plyposis=Yes 33.81995 49.731664 43.377309 3.203071e-04
## urbanization_level=No 32.86004 57.960644 52.031662 8.284634e-04
## household_damage=No 30.77852 91.234347 87.440633 9.577649e-04
## gina_control=partially controlled 32.17489 51.341682 47.071240 1.617065e-02
## household_damage=Yes 20.58824 8.765653 12.559367 9.577649e-04
## urbanization_level=Yes 25.85259 42.039356 47.968338 8.284634e-04
## nasal_plyposis=No 26.18826 50.268336 56.622691 3.203071e-04
## allergen_triggered_asthma=Yes 22.92419 22.719141 29.234828 4.409344e-05
## Ever_rhinitis=No 21.09635 22.719141 31.767810 2.622019e-08
## gina_control=controlled 22.03626 28.264758 37.836412 1.918175e-08
## severe_asthma=No 26.70025 75.849732 83.799472 3.743826e-09
## Recurrent_wheeze=No 25.70850 68.157424 78.205805 2.340878e-11
## Hosptalization_last_year=No 27.60532 89.087657 95.197889 3.991604e-14
## Emergency_last_year=No 25.73946 73.166369 83.852243 3.224529e-15
## Cough=No 23.15036 52.057245 66.332454 5.045310e-17
## smoking_exposure_at_home=No 18.35883 23.613596 37.941953 2.160771e-17
## education=primary 19.89011 32.379249 48.021108 6.518154e-19
## Chronic_productive_cough=No 23.60923 62.254025 77.783641 2.267578e-24
## familial_allergy=Yes 18.62217 30.948122 49.023747 9.550156e-25
## smoking_exposure_at_work=No 20.01741 41.144902 60.633245 7.243320e-29
## dyspenea=No 21.92982 58.139535 78.205805 9.563530e-40
## smoking_status=never smoker 16.81244 30.948122 54.300792 3.586091e-40
## spt_any=Yes 19.23077 42.933810 65.857520 5.661621e-41
## XCOPD=No 23.38369 69.230769 87.335092 5.944927e-48
## v.test
## XCOPD=Yes 14.548785
## education=tertiary 13.660085
## spt_any=No 13.404878
## dyspenea=Yes 13.193503
## smoking_exposure_at_work=Yes 11.148978
## familial_allergy=No 10.270708
## Chronic_productive_cough=Yes 10.186954
## smoking_status=former smokers 9.171267
## smoking_exposure_at_home=Yes 8.484807
## Cough=Yes 8.385634
## Emergency_last_year=Yes 7.881895
## Hosptalization_last_year=Yes 7.561267
## smoking_status=current smoker 7.060895
## Recurrent_wheeze=Yes 6.683007
## severe_asthma=Yes 5.895132
## Ever_rhinitis=Yes 5.564967
## gina_steps=step4 or 5 5.328913
## allergen_triggered_asthma=No 4.084912
## gina_control=uncontrolled 4.072070
## nasal_plyposis=Yes 3.598298
## urbanization_level=No 3.343106
## household_damage=No 3.302648
## gina_control=partially controlled 2.405041
## household_damage=Yes -3.302648
## urbanization_level=Yes -3.343106
## nasal_plyposis=No -3.598298
## allergen_triggered_asthma=Yes -4.084912
## Ever_rhinitis=No -5.564967
## gina_control=controlled -5.619224
## severe_asthma=No -5.895132
## Recurrent_wheeze=No -6.683007
## Hosptalization_last_year=No -7.561267
## Emergency_last_year=No -7.881895
## Cough=No -8.385634
## smoking_exposure_at_home=No -8.484807
## education=primary -8.882828
## Chronic_productive_cough=No -10.186954
## familial_allergy=Yes -10.270708
## smoking_exposure_at_work=No -11.148978
## dyspenea=No -13.193503
## smoking_status=never smoker -13.267227
## spt_any=Yes -13.404878
## XCOPD=No -14.548785
##
## $`1`
## Cla/Mod Mod/Cla Global p.value
## infection_triggered_asthma=No 59.729730 67.3780488 39.050132 1.007907e-75
## weather_triggered_asthma=No 46.821705 92.0731707 68.073879 1.781301e-68
## exertion_triggered_asthma=No 59.322034 64.0243902 37.361478 6.536117e-68
## Breathlessness=No 55.663430 52.4390244 32.612137 4.705226e-40
## gina_steps=onlys saba or non users 43.257989 84.6036585 67.704485 1.822263e-32
## severe_asthma=No 39.357683 95.2743902 83.799472 1.289689e-26
## allergen_triggered_asthma=No 41.759881 85.3658537 70.765172 5.887110e-26
## emotion_triggered_asthma=No 37.644342 99.3902439 91.398417 6.490237e-26
## dyspenea=No 40.215924 90.8536585 78.205805 1.584008e-24
## Recurrent_wheeze=No 40.148448 90.7012195 78.205805 6.232842e-24
## Chronic_productive_cough=No 40.162822 90.2439024 77.783641 2.072044e-23
## irritant_triggered_asthma=No 38.709677 95.1219512 85.065963 6.887756e-22
## Cough=No 41.686555 79.8780488 66.332454 1.587363e-20
## gina_control=controlled 47.698745 52.1341463 37.836412 1.739316e-20
## XCOPD=No 38.066465 96.0365854 87.335092 3.390370e-19
## smoking_exposure_at_work=No 41.253264 72.2560976 60.633245 2.526618e-14
## smoking_status=never smoker 42.176871 66.1585366 54.300792 3.368020e-14
## Emergency_last_year=No 37.696665 91.3109756 83.852243 2.460880e-11
## smoking_exposure_at_home=No 43.115438 47.2560976 37.941953 1.500440e-09
## urbanization_level=Yes 41.364136 57.3170732 47.968338 3.098523e-09
## spt_any=Yes 38.862179 73.9329268 65.857520 5.082243e-08
## Ever_rhinitis=No 42.691030 39.1768293 31.767810 5.787715e-07
## Hosptalization_last_year=No 35.698448 98.1707317 95.197889 2.694266e-06
## education=primary 39.670330 55.0304878 48.021108 8.981966e-06
## household_damage=Yes 41.596639 15.0914634 12.559367 1.679959e-02
## Gender=No 37.565445 43.7500000 40.316623 2.702428e-02
## Gender=Yes 32.625995 56.2500000 59.683377 2.702428e-02
## household_damage=No 33.614967 84.9085366 87.440633 1.679959e-02
## gina_steps=step3 17.708333 2.5914634 5.065963 1.946144e-04
## smoking_status=current smoker 19.760479 5.0304878 8.812665 1.185564e-05
## gina_control=partially controlled 29.260090 39.7865854 47.071240 3.667774e-06
## Hosptalization_last_year=Yes 13.186813 1.8292683 4.802111 2.694266e-06
## Ever_rhinitis=Yes 30.858469 60.8231707 68.232190 5.787715e-07
## smoking_status=former smokers 27.038627 28.8109756 36.886544 9.112187e-08
## gina_steps=step 1 or 2 22.255193 11.4329268 17.783641 6.683721e-08
## spt_any=No 26.429675 26.0670732 34.142480 5.082243e-08
## urbanization_level=No 28.397566 42.6829268 52.031662 3.098523e-09
## smoking_exposure_at_home=Yes 29.421769 52.7439024 62.058047 1.500440e-09
## gina_control=uncontrolled 18.531469 8.0792683 15.092348 1.067458e-10
## Emergency_last_year=Yes 18.627451 8.6890244 16.147757 2.460880e-11
## education=tertiary 14.830508 5.3353659 12.453826 4.994630e-13
## smoking_exposure_at_work=Yes 24.396783 27.7439024 39.366755 2.526618e-14
## XCOPD=Yes 10.833333 3.9634146 12.664908 3.390370e-19
## Cough=Yes 20.689655 20.1219512 33.667546 1.587363e-20
## irritant_triggered_asthma=Yes 11.307420 4.8780488 14.934037 6.887756e-22
## gina_steps=step4 or 5 5.027933 1.3719512 9.445910 4.463249e-23
## Chronic_productive_cough=Yes 15.201900 9.7560976 22.216359 2.072044e-23
## Recurrent_wheeze=Yes 14.769976 9.2987805 21.794195 6.232842e-24
## dyspenea=Yes 14.527845 9.1463415 21.794195 1.584008e-24
## emotion_triggered_asthma=Yes 2.453988 0.6097561 8.601583 6.490237e-26
## allergen_triggered_asthma=Yes 17.328520 14.6341463 29.234828 5.887110e-26
## severe_asthma=Yes 10.097720 4.7256098 16.200528 1.289689e-26
## Breathlessness=Yes 24.432263 47.5609756 67.387863 4.705226e-40
## exertion_triggered_asthma=Yes 19.882056 35.9756098 62.638522 6.536117e-68
## weather_triggered_asthma=Yes 8.595041 7.9268293 31.926121 1.781301e-68
## infection_triggered_asthma=Yes 18.528139 32.6219512 60.949868 1.007907e-75
## v.test
## infection_triggered_asthma=No 18.414351
## weather_triggered_asthma=No 17.487591
## exertion_triggered_asthma=No 17.413337
## Breathlessness=No 13.246853
## gina_steps=onlys saba or non users 11.863926
## severe_asthma=No 10.678038
## allergen_triggered_asthma=No 10.536131
## emotion_triggered_asthma=No 10.526952
## dyspenea=No 10.221783
## Recurrent_wheeze=No 10.088157
## Chronic_productive_cough=No 9.969531
## irritant_triggered_asthma=No 9.615346
## Cough=No 9.286974
## gina_control=controlled 9.277236
## XCOPD=No 8.955227
## smoking_exposure_at_work=No 7.620517
## smoking_status=never smoker 7.583328
## Emergency_last_year=No 6.675680
## smoking_exposure_at_home=No 6.044317
## urbanization_level=Yes 5.926292
## spt_any=Yes 5.448409
## Ever_rhinitis=No 4.998169
## Hosptalization_last_year=No 4.692849
## education=primary 4.440333
## household_damage=Yes 2.391065
## Gender=No 2.211167
## Gender=Yes -2.211167
## household_damage=No -2.391065
## gina_steps=step3 -3.725907
## smoking_status=current smoker -4.380226
## gina_control=partially controlled -4.629371
## Hosptalization_last_year=Yes -4.692849
## Ever_rhinitis=Yes -4.998169
## smoking_status=former smokers -5.343593
## gina_steps=step 1 or 2 -5.399472
## spt_any=No -5.448409
## urbanization_level=No -5.926292
## smoking_exposure_at_home=Yes -6.044317
## gina_control=uncontrolled -6.457075
## Emergency_last_year=Yes -6.675680
## education=tertiary -7.225445
## smoking_exposure_at_work=Yes -7.620517
## XCOPD=Yes -8.955227
## Cough=Yes -9.286974
## irritant_triggered_asthma=Yes -9.615346
## gina_steps=step4 or 5 -9.893027
## Chronic_productive_cough=Yes -9.969531
## Recurrent_wheeze=Yes -10.088157
## dyspenea=Yes -10.221783
## emotion_triggered_asthma=Yes -10.526952
## allergen_triggered_asthma=Yes -10.536131
## severe_asthma=Yes -10.678038
## Breathlessness=Yes -13.246853
## exertion_triggered_asthma=Yes -17.413337
## weather_triggered_asthma=Yes -17.487591
## infection_triggered_asthma=Yes -18.414351
##
## $`2`
## Cla/Mod Mod/Cla Global p.value
## exertion_triggered_asthma=Yes 50.96883 88.970588 62.638522 6.276032e-78
## infection_triggered_asthma=Yes 50.99567 86.617647 60.949868 1.134862e-71
## weather_triggered_asthma=Yes 64.13223 57.058824 31.926121 5.385008e-68
## allergen_triggered_asthma=Yes 59.74729 48.676471 29.234828 5.282532e-43
## Breathlessness=Yes 45.41895 85.294118 67.387863 3.990275e-38
## irritant_triggered_asthma=Yes 62.54417 26.029412 14.934037 4.091901e-23
## familial_allergy=Yes 45.74812 62.500000 49.023747 1.336596e-18
## emotion_triggered_asthma=Yes 67.48466 16.176471 8.601583 1.115098e-17
## spt_any=Yes 41.90705 76.911765 65.857520 1.270237e-14
## XCOPD=No 38.54985 93.823529 87.335092 2.970529e-11
## gina_steps=step 1 or 2 51.63205 25.588235 17.783641 6.747251e-11
## smoking_status=never smoker 41.01069 62.058824 54.300792 3.707076e-07
## gina_steps=step3 56.25000 7.941176 5.065963 3.307719e-05
## education=primary 40.43956 54.117647 48.021108 7.179033e-05
## severe_asthma=Yes 45.92834 20.735294 16.200528 7.760800e-05
## dyspenea=No 37.85425 82.500000 78.205805 6.260367e-04
## Hosptalization_last_year=No 36.69623 97.352941 95.197889 6.863295e-04
## gina_steps=step4 or 5 47.48603 12.500000 9.445910 8.369174e-04
## smoking_exposure_at_work=No 38.72933 65.441176 60.633245 1.317182e-03
## Recurrent_wheeze=Yes 42.13075 25.588235 21.794195 3.005074e-03
## urbanization_level=No 38.74239 56.176471 52.031662 6.914442e-03
## gina_control=partially controlled 38.56502 50.588235 47.071240 2.193519e-02
## nasal_plyposis=No 38.02423 60.000000 56.622691 2.644478e-02
## gina_control=uncontrolled 41.60839 17.500000 15.092348 2.991949e-02
## nasal_plyposis=Yes 33.09002 40.000000 43.377309 2.644478e-02
## urbanization_level=Yes 32.78328 43.823529 47.968338 6.914442e-03
## smoking_status=current smoker 25.74850 6.323529 8.812665 3.635641e-03
## Recurrent_wheeze=No 34.14305 74.411765 78.205805 3.005074e-03
## smoking_exposure_at_work=Yes 31.50134 34.558824 39.366755 1.317182e-03
## Hosptalization_last_year=Yes 19.78022 2.647059 4.802111 6.863295e-04
## dyspenea=Yes 28.81356 17.500000 21.794195 6.260367e-04
## smoking_status=former smokers 30.75823 31.617647 36.886544 3.578173e-04
## severe_asthma=No 33.94207 79.264706 83.799472 7.760800e-05
## gina_control=controlled 30.26499 31.911765 37.836412 6.474887e-05
## XCOPD=Yes 17.50000 6.176471 12.664908 2.970529e-11
## education=tertiary 15.67797 5.441176 12.453826 3.037803e-13
## spt_any=No 24.26584 23.088235 34.142480 1.270237e-14
## emotion_triggered_asthma=No 32.90993 83.823529 91.398417 1.115098e-17
## familial_allergy=No 26.39752 37.500000 50.976253 1.336596e-18
## gina_steps=onlys saba or non users 28.60483 53.970588 67.704485 2.811405e-21
## irritant_triggered_asthma=No 31.20347 73.970588 85.065963 4.091901e-23
## Breathlessness=No 16.18123 14.705882 32.612137 3.990275e-38
## allergen_triggered_asthma=No 26.02535 51.323529 70.765172 5.282532e-43
## weather_triggered_asthma=No 22.63566 42.941176 68.073879 5.385008e-68
## infection_triggered_asthma=No 12.29730 13.382353 39.050132 1.134862e-71
## exertion_triggered_asthma=No 10.59322 11.029412 37.361478 6.276032e-78
## v.test
## exertion_triggered_asthma=Yes 18.687344
## infection_triggered_asthma=Yes 17.902135
## weather_triggered_asthma=Yes 17.424422
## allergen_triggered_asthma=Yes 13.747356
## Breathlessness=Yes 12.909277
## irritant_triggered_asthma=Yes 9.901717
## familial_allergy=Yes 8.802619
## emotion_triggered_asthma=Yes 8.561395
## spt_any=Yes 7.708782
## XCOPD=No 6.648024
## gina_steps=step 1 or 2 6.526170
## smoking_status=never smoker 5.083415
## gina_steps=step3 4.151176
## education=primary 3.970273
## severe_asthma=Yes 3.951669
## dyspenea=No 3.420076
## Hosptalization_last_year=No 3.394983
## gina_steps=step4 or 5 3.340287
## smoking_exposure_at_work=No 3.212210
## Recurrent_wheeze=Yes 2.967218
## urbanization_level=No 2.700937
## gina_control=partially controlled 2.291488
## nasal_plyposis=No 2.219617
## gina_control=uncontrolled 2.171155
## nasal_plyposis=Yes -2.219617
## urbanization_level=Yes -2.700937
## smoking_status=current smoker -2.908158
## Recurrent_wheeze=No -2.967218
## smoking_exposure_at_work=Yes -3.212210
## Hosptalization_last_year=Yes -3.394983
## dyspenea=Yes -3.420076
## smoking_status=former smokers -3.569387
## severe_asthma=No -3.951669
## gina_control=controlled -3.994800
## XCOPD=Yes -6.648024
## education=tertiary -7.292711
## spt_any=No -7.708782
## emotion_triggered_asthma=No -8.561395
## familial_allergy=No -8.802619
## gina_steps=onlys saba or non users -9.469517
## irritant_triggered_asthma=No -9.901717
## Breathlessness=No -12.909277
## allergen_triggered_asthma=No -13.747356
## weather_triggered_asthma=No -17.424422
## infection_triggered_asthma=No -17.902135
## exertion_triggered_asthma=No -18.687344
##
##
## Link between the cluster variable and the quantitative variables
## ================================================================
## Eta2 P-value
## Age 0.401308860 1.713477e-211
## pack_years 0.381226938 6.147564e-198
## tlco 0.308406387 3.155157e-152
## kco 0.289487078 3.864506e-141
## onset_age_asthma 0.277129375 4.691434e-134
## FEV1_FVC_ratio_post 0.170767938 1.168361e-77
## Neutrophiles 0.075534558 5.402371e-33
## Reversibility 0.066991845 3.248075e-29
## Basophiles 0.066974672 3.305124e-29
## pd20 0.065987055 8.991640e-29
## Monocytes 0.062037201 4.870691e-27
## FeNO 0.058658324 1.461952e-25
## Eosinophiles 0.057340238 5.492890e-25
## BMI 0.044609271 1.783394e-19
## Lymphocytes 0.009686685 1.002067e-04
##
## Description of each cluster by quantitative variables
## =====================================================
## $`0`
## v.test Mean in category Overall mean sd in category
## Age 27.472299 6.505188e+01 4.971821e+01 9.190831e+00
## pack_years 26.833725 2.540905e+01 1.194451e+01 1.807577e+01
## onset_age_asthma 22.842245 3.534168e+01 2.149024e+01 1.892012e+01
## pd20 10.975641 2.870432e+03 1.952471e+03 1.993718e+03
## Neutrophiles 10.297112 4.361878e+00 3.856132e+00 1.578366e+00
## Monocytes 8.920045 4.752773e-01 4.264011e-01 1.847501e-01
## Reversibility 7.579384 9.399531e+00 7.333086e+00 9.873160e+00
## BMI 5.652998 2.804147e+01 2.706171e+01 4.802600e+00
## Basophiles 4.399938 3.856887e-02 3.133509e-02 4.954994e-02
## Eosinophiles 3.788147 2.418068e-01 2.196359e-01 1.886639e-01
## Lymphocytes 3.780324 2.074526e+00 1.982802e+00 9.077890e-01
## FeNO -2.517790 2.350760e+01 2.550929e+01 2.118177e+01
## FEV1_FVC_ratio_post -17.491063 7.102636e-01 7.699727e-01 1.185074e-01
## kco -22.352320 8.671352e+01 9.897243e+01 1.449915e+01
## tlco -23.803875 8.478481e+01 1.001420e+02 1.451667e+01
## Overall sd p.value
## Age 1.571245e+01 3.763074e-166
## pack_years 1.412548e+01 1.306309e-158
## onset_age_asthma 1.707061e+01 1.745247e-115
## pd20 2.354436e+03 5.004937e-28
## Neutrophiles 1.382643e+00 7.260871e-25
## Monocytes 1.542493e-01 4.660969e-19
## Reversibility 7.675073e+00 3.471989e-14
## BMI 4.879071e+00 1.576729e-08
## Basophiles 4.628193e-02 1.082819e-05
## Eosinophiles 1.647591e-01 1.517752e-04
## Lymphocytes 6.830395e-01 1.566246e-04
## FeNO 2.238045e+01 1.180938e-02
## FEV1_FVC_ratio_post 9.609862e-02 1.676026e-68
## kco 1.543910e+01 1.146301e-110
## tlco 1.816168e+01 3.045012e-125
##
## $`1`
## v.test Mean in category Overall mean sd in category
## FEV1_FVC_ratio_post 11.923228 8.061557e-01 7.699727e-01 6.547478e-02
## tlco 7.513166 1.044509e+02 1.001420e+02 1.258557e+01
## kco 4.365788 1.011010e+02 9.897243e+01 1.185596e+01
## pd20 -3.291206 1.707770e+03 1.952471e+03 2.892721e+03
## Lymphocytes -3.556162 1.906098e+00 1.982802e+00 5.438038e-01
## FeNO -7.845556 1.996448e+01 2.550929e+01 1.225226e+01
## BMI -9.055683 2.566645e+01 2.706171e+01 4.260206e+00
## Monocytes -9.632410 3.794817e-01 4.264011e-01 1.229169e-01
## Neutrophiles -10.215754 3.410091e+00 3.856132e+00 1.073498e+00
## Eosinophiles -10.348745 1.657927e-01 2.196359e-01 1.071583e-01
## Reversibility -10.919501 4.686543e+00 7.333086e+00 4.784212e+00
## Basophiles -11.218493 1.493902e-02 3.133509e-02 3.369966e-02
## onset_age_asthma -12.308406 1.485518e+01 2.149024e+01 1.186363e+01
## pack_years -13.876115 5.754874e+00 1.194451e+01 6.026262e+00
## Age -14.971583 4.228963e+01 4.971821e+01 1.366805e+01
## Overall sd p.value
## FEV1_FVC_ratio_post 9.609862e-02 8.956965e-33
## tlco 1.816168e+01 5.771430e-14
## kco 1.543910e+01 1.266651e-05
## pd20 2.354436e+03 9.975901e-04
## Lymphocytes 6.830395e-01 3.763121e-04
## FeNO 2.238045e+01 4.310409e-15
## BMI 4.879071e+00 1.357152e-19
## Monocytes 1.542493e-01 5.834464e-22
## Neutrophiles 1.382643e+00 1.685626e-24
## Eosinophiles 1.647591e-01 4.240090e-25
## Reversibility 7.675073e+00 9.300574e-28
## Basophiles 4.628193e-02 3.308618e-29
## onset_age_asthma 1.707061e+01 8.161903e-35
## pack_years 1.412548e+01 8.840776e-44
## Age 1.571245e+01 1.126085e-50
##
## $`2`
## v.test Mean in category Overall mean sd in category
## kco 16.921281 1.069966e+02 9.897243e+01 1.278873e+01
## tlco 15.179629 1.086096e+02 1.001420e+02 1.759758e+01
## FeNO 10.175386 3.250390e+01 2.550929e+01 2.828991e+01
## Basophiles 6.943793 4.120588e-02 3.133509e-02 4.955406e-02
## Eosinophiles 6.662796 2.533529e-01 2.196359e-01 1.759903e-01
## FEV1_FVC_ratio_post 4.803610 7.841511e-01 7.699727e-01 7.523409e-02
## Reversibility 3.624378 8.187483e+00 7.333086e+00 7.137742e+00
## BMI 3.607268 2.760228e+01 2.706171e+01 5.187577e+00
## pd20 -7.170721 1.433918e+03 1.952471e+03 1.757438e+03
## onset_age_asthma -9.509211 1.650441e+01 2.149024e+01 1.252902e+01
## Age -11.269770 4.427941e+01 4.971821e+01 1.273721e+01
## pack_years -11.749184 6.847037e+00 1.194451e+01 6.358852e+00
## Overall sd p.value
## kco 1.543910e+01 3.135346e-64
## tlco 1.816168e+01 4.825049e-52
## FeNO 2.238045e+01 2.553864e-24
## Basophiles 4.628193e-02 3.817099e-12
## Eosinophiles 1.647591e-01 2.686666e-11
## FEV1_FVC_ratio_post 9.609862e-02 1.558304e-06
## Reversibility 7.675073e+00 2.896573e-04
## BMI 4.879071e+00 3.094381e-04
## pd20 2.354436e+03 7.460355e-13
## onset_age_asthma 1.707061e+01 1.921148e-21
## Age 1.571245e+01 1.850517e-29
## pack_years 1.412548e+01 7.130402e-321.5.8 Radar Plots
1.5.9 parallel box plots
1.5.10 parallel coordinate plot
